ECOG Specimen Banking

描述（由申请人提供）：ECOG组织库是ECOG转化科学项目的关键部分，为ECOG成员和非成员机构的研究人员提供了宝贵的资源。本申请建议继续支持这些银行的协调和运作，目标是收集、处理和储存高质量的标本，并使它们可供研究人员用于经批准的相关科学项目。ECOG将增加其用于尖端研究的高质量标本库的营销，这反过来将改变临床护理。ECOG是nci -临床试验合作小组银行委员会（GBC）的积极参与者，并致力于与GBC合作，通过ECOG在指导委员会和小组委员会中的代表，实现在所有合作小组银行中收集、处理、储存和分发标本的统一系统的共同目标。通用技术的使用确保了样本在前沿研究中具有足够的质量，便于从多个样本库中汇集样本用于大规模的转化项目，并增强了跨项目比较结果的能力。共同的词汇表和数据结构，以及样本请求的共同政策，使系统更容易为所有调查人员导航，而不管合作小组的成员身份。这就创造了一个学院式的、强大的、富有成效的癌症研究体系。三个主要的ECOG标本库是实体瘤库（ECOG PCO-RL），白血病组织库和骨髓瘤组织库。每家机构都根据推荐的最佳做法，按照严格的标准操作规程，从合作小组临床试验中收集和保存有充分注释的标本，并遵循GBC惯例，使研究人员能够获得这些标本。

DESCRIPTION (provided by applicant): The ECOG tissue banks are a critical part of ECOG's translational science program, providing a valuable resource to investigators at both ECOG member and non-member institutions. This application proposes continued support for the coordination and operation of these banks with the goal of collecting, processing, and storing high-quality specimens and making them available to investigators for use in approved correlative science projects. ECOG will increase the marketing of its high quality banked specimens for use in cutting edge research which in turn will change clinical care. ECOG is an active participant in the NCI-Clinical Trials Cooperative Groups' Group Banking Committee (GBC) and is committed to working with the GBC, through ECOG representation on the Steering Committee and subcommittees, toward the common goal of a harmonized system for the collection, processing, storage, and distribution of specimens across all Cooperative Group Banks. The use of common techniques ensures that samples are of sufficient quality for use in cutting edge research, facilitates pooling specimens from multiple banks for large scale translational projects, and enhances the ability to compare results across projects. Common vocabularies and data structures, as well as common policies for specimen requests, make the system easier to navigate for ail investigators regardless of cooperative group membership status. This creates a collegial, robust and productive cancer research system. The three main ECOG specimen banks are the Solid Tumor Bank (the ECOG PCO-RL), the Leukemia Tissue Bank, and the Myeloma Tissue Bank. Each collects and banks well annotated specimens from Cooperative Group clinical trials according to strict SOPs based on recommended Best Practices and follows GBC practices to make them available to investigators.