Gynecologic Oncology Group Specimen Banking

妇科肿瘤组样本库

• 批准号: 7991466
• 负责人: Philip J. DiSaia
• 金额: $ 59.65万
• 依托单位: GYNECOLOGIC ONCOLOGY GROUP
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7991466
• 关键词: Canada; Cervical; Clinical Trials; Cooperative Human Tissue Network; Data; Data Collection; Discipline; Drug or chemical Tissue Distribution; Enrollment; Grant; Gynecologic; Gynecologic Oncology Group; Improve Access; Institution; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Medical Research; Medicine; Microscopy; Molecular; Monitor; Nucleic Acids; Ovarian; Paper; Pathology; Patients; Peritoneal; Process; Research; Research Personnel; Specimen; Specimen Handling; Technology; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; United States; base; data exchange; digital; insight; meetings; multidisciplinary; novel therapeutic intervention; novel therapeutics; programs; virtual; web site

DESCRIPTION (provided by applicant): The Gynecologic Oncology Group (GOG) is a premier multidisciplinary, multimodal clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. The GOG Tissue Bank, through the Tissue Utilization Subcommittee of the Committee on Experimental Medicine, is an integral part of this program. Since 2003, the GOG Tissue Bank has received and processed specimens from close to 46,000 patients enrolled at over 250 institutions. The Bank also distributed over 81,000 specimens to 215 investigators, resulting in 122 scientific papers. This is reflective of improved access by investigators to the GOG Tissue Bank via NCI web sites and networking of investigators via the Cooperative Human Tissue Network. The GOG Tissue Bank monitors and modifies its tissue procurement and distribution technologies to meet changing investigator needs. This is evidenced by the introduction of tissue microarray and virtual microscopy technologies during the last grant cycle, Our Specific Aims are; 1. To extend the spectrum of molecular research in gynecologic cancer via expanded procurement of not only ovarian, but also cervical, uterine, primary peritoneal and rare gynecologic malignancies. 2. To enhance biospecimen data collection and exchange with the Statistical Data Center and all participating GOG disciplines and committees to advance translational research and high-impact discoveries. 3. To extend the spectrum of virtual microscopy and digital pathology for gynecologic cancer via expanded participation, use, and functionality of the technology 4. To continue to expand tissue-based technologies including nucleic acid extractions and tissue microarrays (TMAs) to facilitate molecular research. 5. To harmonize with other Cooperative Group Banks through NCI Group Banking Committee initiatives to simplify investigators' access to biospecimens and associated data. RELEVANCE: The Gynecologic Oncology Group (GOG) Tissue Bank receives processes and stores gynecologic cancer specimens from patients enrolled on GOG clinical trials. These specimens are then distributed to investigators across the United States and Canada for use in medical research. The results of this research range from gaining new insights into how cancers develop and progress to the efficacy of new therapeutic regiments.

描述（由申请人提供）：妇科肿瘤小组 (GOG) 是一个首要的多学科、多模式临床试验研究项目，研究妇科恶性肿瘤管理的新治疗方法。 GOG 组织库，通过实验医学委员会的组织利用小组委员会，是该计划的一个组成部分。自 2003 年以来，GOG 组织库已接收并处理了来自 250 多家机构的近 46,000 名患者的样本。该银行还向 215 名研究人员分发了 81,000 多个样本，产生了 122 篇科学论文。这反映了研究人员通过 NCI 网站访问 GOG 组织库以及通过合作人体组织网络建立研究人员网络的改进。 GOG 组织库监控并修改其组织采购和分配技术，以满足不断变化的研究者需求。上一个资助周期中组织微阵列和虚拟显微镜技术的引入证明了这一点，我们的具体目标是： 1. 通过扩大对卵巢癌、宫颈癌、子宫癌、原发性腹膜癌和罕见妇科恶性肿瘤的研究，扩大妇科癌症的分子研究范围。 2. 加强生物样本数据收集以及与统计数据中心和所有参与的 GOG 学科和委员会的交流，以推进转化研究和高影响力的发现。 3. 通过扩大技术的参与、使用和功能，扩展妇科癌症的虚拟显微镜和数字病理学范围。 4. 继续扩展基于组织的技术，包括核酸提取和组织微阵列 (TMA)，以促进分子研究。 5. 通过 NCI 集团银行委员会举措与其他合作集团银行进行协调，以简化研究人员获取生物样本和相关数据的过程。 相关性：妇科肿瘤小组 (GOG) 组织库接收处理并存储参加 GOG 临床试验的患者的妇科癌症标本。然后，这些标本被分发给美国和加拿大的研究人员用于医学研究。这项研究的结果范围从获得对癌症如何发展和进展的新见解到新治疗方案的功效。