Gynecologic Oncology Group- HUMAN SPECIMEN BANK

妇科肿瘤组 - 人类样本库

• 批准号: 7909596
• 负责人: Philip J. DiSaia
• 金额: $ 54.32万
• 依托单位: GYNECOLOGIC ONCOLOGY GROUP
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7909596
• 关键词: Accounting; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Community Hospitals; Cooperative Human Tissue Network; Data; Development; Disease; Enrollment; Ensure; Epithelial; Gene Expression; Gynecologic; Gynecologic Oncology Group; Health; Improve Access; Institution; Leukocytes; Maintenance; Malignant Neoplasms; Medicine; Molecular; Monitor; Normal tissue morphology; Ovarian; Paper; Participant; Patients; Procedures; Process; Proteomics; Protocols documentation; Qualifying; Research; Research Personnel; Resources; Scientist; Specimen; Supervision; Technology; Therapeutic; Tissue Banking; Tissue Banks; Tissue Procurements; Tissues; Translational Research; Tumor Bank; Universities; flexibility; innovative technologies; medical specialties; meetings; multidisciplinary; novel therapeutic intervention; programs; tissue processing; treatment trial; web site

DESCRIPTION (provided by applicant): The Gynecologic Oncology Group (GOG) is the premier clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. This multidisciplinary, multimodal Group comprises over 200 participating university and large community hospitals with over 3000 investigator-participants in all specialties of cancer study. An important component of the program is the Committee on Experimental Medicine (CEM) composed of basic and clinical scientists with active studies of cancer translational research. The CEM has oversight over the GOG Tissue Bank through its' Tissue Utilization Subcommittee (TUS). Over the decade of its existence, the GOG Tissue Bank has received and processed tissue from more than 6,100 patients and served over 52,000 specimens to approximately 146 investigators. Over one-half (54%) of all bank registrations are ovarian epithelial malignancies and 52% of these are on a therapeutic protocol. For the general GOG banking protocol (GOG-136), 95% of cases have paired normal tissue (22% with white blood cell pellets), an important adjunct for molecular studies. Nearly 100 institutions submit specimens each year. The number of tissues distributed represents improved access by investigators to the GOG Tissue Bank via NCI web sites and networking of investigators via the Cooperative Human Tissue Network. The GOG Tissue Bank has accounted for 146 scientific papers over the last 10 years, with an increased emphasis on gene expression microarray and proteomics studies within the last two years. The GOG Tissue Bank is poised and flexible to monitor and modify its tissue procurement and distribution technologies to meet changing investigator needs. The Specific Aims of this project are: 1. Management of specimens from patients enrolled in NCI-sponsored clinical treatment trials to maintain an accurate and effective bank of tumor and normal tissues with associated clinical, epidemiologic and protected health information. 2. Promotion of studies by qualified investigators with supervision by the GOG Committee on Experimental Medicine as well as disease-specific committees of the GOG. 3. Expansion of innovative technologies facilitating molecular research and increased investigator participation in clinical research trials. 4. Maintenance of strict control procedures to ensure high quality capture, processing and distribution of specimens. 5. Participation in the development of scientific papers and presentations describing the results of this valuable tissue and data resource.

描述（由申请人提供）： 妇科肿瘤组（GOG）是研究妇科恶性肿瘤管理新治疗方法的首要临床试验研究项目。这个多学科、多模式的小组由200多家参与的大学和大型社区医院组成，在癌症研究的所有专业中有3000多名参与者。该计划的一个重要组成部分是实验医学委员会（CEM），由积极研究癌症转化研究的基础和临床科学家组成。CEM通过其组织利用小组委员会（TUS）对GOG组织库进行监督。成立十年来，GOG组织库已接收和处理了6，100多名患者的组织，并向大约146名研究人员提供了52，000多份标本。超过一半（54%）的所有银行登记是卵巢上皮恶性肿瘤，其中52%是治疗方案。对于一般GOG建库方案（GOG-136），95%的病例具有配对的正常组织（22%具有白色血细胞团），这是分子研究的重要辅助手段。每年有近100个机构提交标本。分发的组织数量代表了研究人员通过NCI网站访问GOG组织库的机会增加，以及研究人员通过合作人体组织网络建立网络。GOG组织库在过去10年中发表了146篇科学论文，在过去两年中越来越重视基因表达微阵列和蛋白质组学研究。GOG组织库准备和灵活地监测和修改其组织采购和分配技术，以满足不断变化的研究者需求。 该项目的具体目标是： 1.管理入组NCI申办的临床治疗试验的患者标本，以维持准确有效的肿瘤和正常组织库，以及相关的临床、流行病学和受保护的健康信息。 2.在GOG实验医学委员会以及GOG疾病特异性委员会的监督下，促进合格研究人员的研究。 3.扩大促进分子研究的创新技术，增加临床研究试验中的研究者参与。 4.维持严格的控制程序，以确保高质量的标本采集、处理和分发。 5.参与编写科学论文和介绍，描述这一宝贵的组织和数据资源的结果。