National Cell Respository for Alzheimer's Disease (NCRAD) (U24)

国家阿尔茨海默病细胞存储库 (NCRAD) (U24)

• 批准号: 8218130
• 负责人: TATIANA M. FOROUD
• 金额: $ 94.51万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8218130
• 关键词: Advisory Committees; Affect; Age; Aliquot; Alzheimer' s Disease; Alzheimer' s disease risk; American; Biological; Biological Markers; Blood specimen; Brain; Cell Line; Cells; Clinical Data; Communities; Core Facility; DNA; DNA Library; DNA Sequence; Data; Data Coordinating Center; Dementia; Disease; Disease susceptibility; Enrollment; Ensure; Etiology; Family; Fostering; Frequencies; Funding; Future; Genetic; Genome; Genomics; Genotype; Goals; Human Resources; Indiana; Individual; Lifting; Manuscripts; Measures; Meta-Analysis; Mission; National Institute on Aging; Onset of illness; Paper; Physicians; Plasma; Play; Positioning Attribute; Principal Investigator; Procedures; Protocols documentation; Publications; Qualifying; RNA; Recruitment Activity; Research; Research Personnel; Resources; Risk; Sampling; Secure; Solutions; Source; Specimen; Testing; Time; U-Series Cooperative Agreements; United States National Institutes of Health; Variant; Work; base; brain tissue; cell bank; data sharing; distributed data; exome; genome-wide; improved; meetings; new technology; prevent; repository; research study; sample collection; success; tool

DESCRIPTION (provided by applicant): The National Cell Repository for Alzheimer's Disease (NCRAD) plays a key role in the National Institute on Aging's (NIA) efforts to identify those at risk for Alzheimer disease (AD) and develop improved treatments to delay or prevent disease onset NCRAD was established as a cooperative agreement with the NIA to serve as the primary source of sample sharing for all NIA-funded dementia studies. Under the advisement of NIA and the Cell Bank Advisory Committee, it is the mission of NCRAD to remove critical barriers hindering research progress to understand the etiology of dementia. To achieve this goal, NCRAD has two primary functions: sample banking and sample distribution. NCRAD serves as a central repository banking samples from ongoing NIA funded studies using uniform protocols with extensive quality measures. The type of samples being banked has expanded to include DNA, cell lines, plasma, serum, brain tissue and RNA. NCRAD works closely with the National Alzheimer Coordinating Center (NACC), another NIA core facility that serves as the data coordinating center for all the Alzheimer Disease Centers (ADCs). Together, NCRAD and NACC serve as key resources within the Alzheimer Disease Genetics Consortium (ADGC), coordinating the collection of samples from the 29 ADCs. NCRAD also widely distributes samples both to investigators for their own analyses as well as to central cores, where APOE genotyping, genome wide SNP arrays, and now whole genome and whole exome sequencing studies are performed. We propose to expand our successful efforts with the following specific aims; 1. To provide a state-of-the-art central bio specimen repository for all NIA-funded dementia studies that includes detailed standard operating procedures for the secure banking of DNA, cell lines, plasma, serum, RNA, and brain tissue. 2. To facilitate and foster sample sharing by distributing data and biospecimens to all qualified investigators for use in their research studies. PUBLIC HEALTH RELEVANCE: There are a number of barriers that hamper the ability of researchers to perform successful studies of Alzheimer disease and related dementias. These include the ability to share samples, access to large numbers of high quality samples and effective sharing of research results. NCRAD under the advisement of NIA and CBAC will lift these ban-iers and facilitate sample and data sharing among dementia researchers.

描述（由申请人提供）：国家阿尔茨海默病细胞库（NCRAD）在国家老龄化研究所（NIA）努力识别阿尔茨海默病（AD）风险并开发改善的治疗方法以延迟或预防疾病发作方面发挥着关键作用。NCRAD作为与NIA的合作协议而建立，作为所有NIA资助的痴呆症研究的样本共享的主要来源。在NIA和细胞库咨询委员会的支持下，NCRAD的使命是消除阻碍研究进展的关键障碍，以了解痴呆症的病因。为了实现这一目标，NCRAD有两个主要功能：样本库和样本分发。 NCRAD作为一个中央储存库，储存来自正在进行的NIA资助的研究的样本，使用统一的协议和广泛的质量措施。被储存的样本类型已经扩大到包括DNA、细胞系、血浆、血清、脑组织和RNA。NCRAD与国家阿尔茨海默病协调中心（NACC）密切合作，NACC是另一个NIA核心设施，作为所有阿尔茨海默病中心（ADC）的数据协调中心。NCRAD和NACC共同作为阿尔茨海默病遗传学联盟（ADGC）的关键资源，协调从29个ADC收集样本。NCRAD还将样本广泛分发给研究人员进行自己的分析，以及进行APOE基因分型、全基因组SNP阵列以及现在进行全基因组和全外显子组测序研究的中心核心。我们建议扩大我们的成功努力，具体目标如下：1.为所有NIA资助的痴呆症研究提供最先进的中央生物标本库，其中包括DNA，细胞系，血浆，血清，RNA和脑组织安全银行的详细标准操作程序。2.通过将数据和生物标本分发给所有合格的研究者用于其研究，促进和促进样本共享。 公共卫生相关性：有许多障碍阻碍了研究人员成功研究阿尔茨海默病和相关痴呆症的能力。其中包括分享样本的能力、获得大量高质量样本的机会以及有效分享研究成果。在NIA和CBAC的支持下，NCRAD将打破这些障碍，促进痴呆研究人员之间的样本和数据共享。