Quantitative Assessment of Dynamic Joint Instabilities Using 4D CT Imaging
使用 4D CT 成像定量评估动态关节不稳定性
基本信息
- 批准号:8120904
- 负责人:
- 金额:$ 16.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-01 至 2013-02-28
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAddressArthritisBackBiomechanicsBone SurfaceClinicalClinical TrialsComplexCustomDataDeformityDegenerative DisorderDegenerative polyarthritisDevicesDiagnosisDiagnosticDiagnostic ImagingDisciplineDoseEarly DiagnosisFeasibility StudiesFluoroscopyFoundationsFour-dimensionalGoalsGoldHip region structureHumanImageImageryImaging DeviceImaging TechniquesIndividualInterventionJoint InstabilityJointsKneeLeadLeftMeasurementMeasuresMethodsMorphologic artifactsMotionOccupationalOperative Surgical ProceduresOpticsOutcomePainPathologicPathologyPatient CarePatientsPhysiciansPlayPublic HealthQualifyingRadiationResearch PersonnelResourcesShoulderSourceSpecimenStagingSystems AnalysisTechniquesTechnologyTestingTimeTranslatingWorkWristWrist jointX-Ray Computed Tomographybasebioimagingbonebone geometrycarpus bonecostdesignexperiencefunctional disabilityhuman subjectimage processingimage registrationin vivoinnovationjoint functionkinematicsmeetingsmoviepreventproductivity losspublic health relevancetooltwo-dimensional
项目摘要
DESCRIPTION (provided by applicant): Clinical techniques to diagnose abnormal wrist joint motion are highly subjective and have a high false positive rate. Additionally, routine radiographic examinations cannot demonstrate dynamic wrist instabilities. This is a significant clinical problem, since individuals suffering from wrist joint instabilities experience progressive degenerative disease that leads to functional disabilities and osteoarthritis (OA). The associated pain prevents them not only from conducting important occupational tasks, but often simple activities of daily living. However, if physicians are able to diagnose dynamic joint instabilities at an early stage, surgical intervention can restore normal function before the onset of arthritis or static deformities. Thus, to have a critical impact on clinical outcomes, a method that allows early detection of functional wrist joint abnormalities is desperately needed. To address this significant public health problem, the long-term goal of our team is to non-invasively diagnose and quantify subtle dynamic joint instabilities of the wrist that can only be observed during joint motion. We have shown that we can meet this critical need using four-dimensional (4D; 3D + time) CT imaging techniques. Based on our successful preliminary work, our central hypothesis is that we can non-invasively determine the complex motion paths of the carpal bones using 4D CT imaging techniques. Our objective in this application is to develop a practical 4D CT examination to detect abnormal wrist joint motion occurring as a result of scapholunate instability. Specifically, in Aim 1, we will develop a robust low dose 4D CT imaging technique to image joint motion in the wrist. Our working hypothesis is that low dose dual-source CT can provide artifact-free images of the moving wrist, at velocities similar to those of activities of daily living. We will develop biomechanical motion devices to test this hypothesis in cadaveric specimens, and determine the minimum radiation dose levels. In Aim 2, we will measure the accuracy and precision of the developed techniques using cadaveric specimens, an optical-based motion analysis system, image registration techniques, and a custom motion simulator. Finally, in Aim 3, we will determine the clinical feasibility of 4D CT wrist joint imaging in asymptomatic subjects and subjects with joint instability. The innovation of this proposal is the use of state-of-the-art CT technology to provide a robust, low dose imaging technique capable of detecting dynamic wrist joint instabilities. We expect three important outcomes: 1) an optimized low dose clinical CT technique for the quantification of wrist articulation, 2) accuracy and precision data for the developed technique, and 3) the first in vivo 4D assessments of wrist joint articulation in both symptomatic and asymptomatic human subjects. These data will provide the foundation for clinical trials to quantify normative and pathologic wrist joint motion. The significance of this proposal is that by diagnosing dynamic wrist joint instabilities at an early stage, intervention to restore normal motion can markedly reduce the human suffering, loss of productivity, and personal and societal costs associated with OA of the wrist.
PUBLIC HEALTH RELEVANCE: The goal of this proposal is to design a computed tomography exam (CT, or CAT scan) that can take highly-detailed pictures of the wrist joint while the patient is moving the joint. These three-dimensional movies of the patient's bones can be played back, looking at the joint from any angle, to let the physician see and measure exactly how the surfaces of the bones move. This is very important because abnormal joint motion, which is currently very hard to accurately diagnose, can lead to pain, arthritis or crippling deformities when left untreated.
描述(由申请人提供):诊断异常腕关节运动的临床技术具有高度主观性,并且具有较高的假阳性率。此外,常规放射学检查不能显示动态腕关节不稳定。这是一个重要的临床问题,因为患有腕关节不稳定的个体经历导致功能障碍和骨关节炎(OA)的进行性退行性疾病。相关的疼痛不仅使他们无法进行重要的职业任务,而且往往是简单的日常生活活动。然而,如果医生能够在早期诊断动态关节不稳定,手术干预可以在关节炎或静态畸形发作之前恢复正常功能。因此,为了对临床结果产生关键影响,迫切需要一种允许早期检测功能性腕关节异常的方法。为了解决这一重大的公共卫生问题,我们团队的长期目标是非侵入性地诊断和量化手腕的细微动态关节不稳定性,这些不稳定性只能在关节运动期间观察到。我们已经证明,我们可以满足这一关键需求,使用四维(4D; 3D +时间)CT成像技术。基于我们成功的初步工作,我们的中心假设是,我们可以非侵入性地确定复杂的运动路径的腕骨使用4D CT成像技术。我们的目的是在这个应用程序中开发一个实用的4D CT检查,以检测异常腕关节运动发生的舟月骨不稳定的结果。具体而言,在目标1中,我们将开发一种稳健的低剂量4D CT成像技术,以成像手腕中的关节运动。我们的工作假设是,低剂量双源CT可以提供无伪影图像的运动手腕,在速度类似的日常生活活动。我们将开发生物力学运动设备,以测试这一假设在尸体标本,并确定最低辐射剂量水平。在目标2中,我们将使用尸体标本、基于光学的运动分析系统、图像配准技术和自定义运动模拟器来测量所开发技术的准确性和精密度。最后,在目标3中,我们将确定4D CT腕关节成像在无症状受试者和关节不稳定受试者中的临床可行性。该提案的创新之处在于使用最先进的CT技术,提供一种能够检测动态腕关节不稳定性的稳健、低剂量成像技术。我们预计有三个重要成果:1)用于量化腕关节的优化低剂量临床CT技术,2)所开发技术的准确性和精密度数据,以及3)有症状和无症状人类受试者腕关节关节的首次体内4D评估。这些数据将为临床试验提供基础,以量化规范和病理性腕关节运动。该建议的意义在于,通过在早期诊断动态腕关节不稳定性,恢复正常运动的干预可以显著减少与腕关节OA相关的人类痛苦、生产力损失以及个人和社会成本。
公共卫生相关性:该提案的目标是设计一种计算机断层扫描检查(CT或CAT扫描),可以在患者移动关节时拍摄腕关节的高度详细的照片。这些病人骨骼的三维电影可以回放,从任何角度观察关节,让医生看到并准确测量骨骼表面是如何移动的。这一点非常重要,因为目前很难准确诊断的关节运动异常,如果不加以治疗,可能会导致疼痛、关节炎或严重畸形。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Cynthia H McCollough其他文献
Cynthia H McCollough的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Cynthia H McCollough', 18)}}的其他基金
Quantitative, non-invasive characterization of urinary stone composition and fragility using multi-energy CT and machine learning techniques
使用多能量 CT 和机器学习技术对尿路结石成分和脆性进行定量、非侵入性表征
- 批准号:
10377461 - 财政年份:2019
- 资助金额:
$ 16.56万 - 项目类别:
Trade-offs in human observer performance, image quality metrics, and patient dose
人类观察者表现、图像质量指标和患者剂量的权衡
- 批准号:
9901529 - 财政年份:2019
- 资助金额:
$ 16.56万 - 项目类别:
Trade-offs in human observer performance, image quality metrics, and patient dose
人类观察者表现、图像质量指标和患者剂量的权衡
- 批准号:
10322422 - 财政年份:2019
- 资助金额:
$ 16.56万 - 项目类别:
Critical resources to evaluate CT scan techniques and dose reduction approaches
评估 CT 扫描技术和剂量减少方法的关键资源
- 批准号:
9261249 - 财政年份:2016
- 资助金额:
$ 16.56万 - 项目类别:
Photon-Counting Spectral CT to Reduce Dose and Detect Early Vascular Disease
光子计数能谱 CT 可减少剂量并检测早期血管疾病
- 批准号:
8921199 - 财政年份:2013
- 资助金额:
$ 16.56万 - 项目类别:
Critical resources to evaluate CT scan techniques and dose reduction approaches
评估 CT 扫描技术和剂量减少方法的关键资源
- 批准号:
8719101 - 财政年份:2013
- 资助金额:
$ 16.56万 - 项目类别:
Photon-Counting Spectral CT to Reduce Dose and Detect Early Vascular Disease
光子计数能谱 CT 可减少剂量并检测早期血管疾病
- 批准号:
8636831 - 财政年份:2013
- 资助金额:
$ 16.56万 - 项目类别:
Critical resources to evaluate CT scan techniques and dose reduction approaches
评估 CT 扫描技术和剂量减少方法的关键资源
- 批准号:
9134142 - 财政年份:2013
- 资助金额:
$ 16.56万 - 项目类别:
Critical resources to evaluate CT scan techniques and dose reduction approaches
评估 CT 扫描技术和剂量减少方法的关键资源
- 批准号:
8550930 - 财政年份:2013
- 资助金额:
$ 16.56万 - 项目类别:
Photon-Counting Spectral CT to Reduce Dose and Detect Early Vascular Disease
光子计数能谱 CT 可减少剂量并检测早期血管疾病
- 批准号:
9133377 - 财政年份:2013
- 资助金额:
$ 16.56万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 16.56万 - 项目类别:
Research Grant