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PHIS+: Augmenting the Pediatric Health Information System with Clinical Data

PHIS：利用临床数据增强儿科健康信息系统

基本信息

批准号：
8326970
负责人：
RON KEREN
金额：
$ 291.03万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8326970
关键词：
PHIS+Augmenting Pediatric Health Information

项目摘要

DESCRIPTION (provided by applicant): The objective of the PHIS+ project is to build on the existing infrastructure provided by Child Health Corporation of America (CHCA)--a business alliance networking 42 of North America's leading children's hospitals--to augment its existing database with laboratory and radiology data for children seen in the ambulatory and inpatient departments of 6 large children's hospitals. The existing database, called the Pediatric Health Information System (PHIS), is a comprehensive pediatric database containing clinical and financial details of more than six million patient cases. The enhanced database, called PHIS+, will provide a rich data source for academic clinicians to answer in real time the comparative effectiveness questions that affect hospitalized children, thereby significantly enhancing the quality and scope of pediatric comparative effectiveness research. The specific aims are: 1. To develop the infrastructure for accurately and reliably performing quarterly downloads of laboratory results and radiology reports from 6 CHCA-member children's hospitals into the existing Pediatric Health Information System (PHIS). 2. To demonstrate the utility of the PHIS+ database in the performance of multiple comparative effectiveness research studies The hospitals collaborating on this proposal are national leaders in the use of electronic medical records and will provide highly accurate and complete clinical data collected as a routine part of clinical care. The outlined proposal will build the data platform needed to make advances in the following 4 areas: (1) Make the most efficient use of our diagnostic armamentarium (i.e. laboratory testing and imaging studies) to predict outcomes, select appropriate interventions, and improve the health status of hospitalized children; (2) Apply state-of-the- art observational study design and analysis to existing data in administrative and clinical databases in to evaluate therapeutic, prognostic, and diagnostic strategies for conditions for which randomized controlled trials are not feasible; (3) Perform economic evaluations of inpatient management strategies to inform resource allocation and, coupled with outcomes measurement, better understand value; and (4) Develop quality measures and severity adjustment tools to study inpatient quality (comparing hospitals, providers, systems) across multiple institutions using large administrative and clinical databases. The PHIS+ project will use an existing robust computational infrastructure-The Federated Utah Research and Translation Health electronic Repository (FURTHeR)-to link data from 6 children's hospitals (with the potential to expand to more) and sites of care (inpatient, outpatient, Emergency Department, Day Surgery) and conduct meaningful comparative effectiveness research in several AHRQ priority areas for several AHRQ priority populations, including children, children with multiple co-morbidities, minorities, and those from lower socioeconomic status. PUBLIC HEALTH RELEVANCE: The construction of the PHIS+ database proposed in this application will provide academic clinicians with a rich data source to study large proportions of the pediatric population and answer in real time the comparative effectiveness questions that affect hospitalized children. With this enhanced database, researchers will be able to predict outcomes, evaluate treatment strategies, select appropriate interventions, evaluate cost effectiveness, and measure quality of care. The research conducted with the PHIS+ database will improve the health status of hospitalized children including those in AHRQ identified priority populations such as minorities, those with multiple co-morbidities, and those from lower socioeconomic status.

描述（由申请人提供）：公共卫生信息系统+项目的目标是建立在由美国儿童健康公司（CHCA）提供的现有基础设施上——一个由北美42家主要儿童医院组成的商业联盟——为6家大型儿童医院的门诊和住院部的儿童增加其现有的实验室和放射学数据数据库。现有的数据库称为儿科健康信息系统（PHIS），是一个综合性的儿科数据库，包含600多万例患者的临床和财务细节。被称为PHIS+的增强数据库将为学术临床医生提供丰富的数据源，以便实时回答影响住院儿童的比较有效性问题，从而显著提高儿科比较有效性研究的质量和范围。具体目标是：1。发展基础设施，以便准确可靠地将6家chca成员儿童医院的实验室结果和放射学报告每季度下载到现有的儿童卫生信息系统（PHIS）中。2. 为了证明公共卫生信息系统+数据库在多项比较有效性研究中的效用，参与这项提议的医院在使用电子病历方面处于全国领先地位，并将提供作为临床护理常规部分收集的高度准确和完整的临床数据。概述的提案将建立在以下4个领域取得进展所需的数据平台：(1)最有效地利用我们的诊断设备（即实验室检测和成像研究）来预测结果，选择适当的干预措施，并改善住院儿童的健康状况；(2)对管理和临床数据库中的现有数据进行最先进的观察性研究设计和分析，以评估随机对照试验不可行的疾病的治疗、预后和诊断策略；(3)对住院患者管理策略进行经济评估，为资源分配提供信息，并结合结果测量，更好地了解价值；(4)开发质量措施和严重程度调整工具，利用大型行政和临床数据库研究多个机构的住院病人质量（比较医院、提供者和系统）。公共卫生信息系统+项目将使用现有的强大的计算基础设施——犹他联邦研究和翻译健康电子存储库（FURTHeR）——将来自6家儿童医院（有可能扩展到更多）和护理地点（住院、门诊、急诊科、日间外科）的数据链接起来，并在几个AHRQ优先领域对几个AHRQ优先人群（包括儿童）进行有意义的比较有效性研究。患有多种合并症的儿童、少数民族儿童和社会经济地位较低的儿童。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Federating clinical data from six pediatric hospitals: process and initial results from the PHIS+ Consortium.

联合六家儿科医院的临床数据：PHIS 联盟的流程和初步结果。

DOI：
发表时间：
2011
期刊：
AMIA ... Annual Symposium proceedings. AMIA Symposium
影响因子：
0
作者：
Narus,ScottP;Srivastava,Rajendu;Gouripeddi,Ramkiran;Livne,OrenE;Mo,Peter;Bickel,JonathanP;deRegt,David;Hales,JosephW;Kirkendall,Eric;Stepanek,RichardL;Toth,Jamie;Keren,Ron
通讯作者：
Keren,Ron

Comparison of Empiric Antibiotics for Acute Osteomyelitis in Children.

儿童急性骨髓炎经验性抗生素的比较。

DOI：
10.1542/hpeds.2017-0079
发表时间：
2018
期刊：
Hospital pediatrics
影响因子：
0
作者：
McBride,Sarah;Thurm,Cary;Gouripeddi,Ramkiran;Stone,Bryan;Jaggard,Phil;Shah,SamirS;Tieder,JoelS;Butcher,Ryan;Weiser,Jason;Hall,Matt;Keren,Ron;Landrigan,ChristopherP
通讯作者：
Landrigan,ChristopherP

Enhancing Comparative Effectiveness Research With Automated Pediatric Pneumonia Detection in a Multi-Institutional Clinical Repository: A PHIS+ Pilot Study.