MR Brain Diffusion Tensor Imaging in Schizophrenia

精神分裂症的 MR 脑扩散张量成像

• 批准号: 8195956
• 负责人: Martha E. Shenton
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195956
• 关键词: Address; Affect; Age; Anisotropy; Anterior; Area; Astrocytes; Attention; Auditory; Auditory Hallucination; Auditory area; Autopsy; Award; Behavior; Bibliography; Biological; Biological Markers; Brain; Brain Diseases; Brain region; Categories; Cell Nucleus; Cells; Chronic; Chronic Schizophrenia; Clinical; Code; Cognition; Cognitive; Communication; Computers; Control Groups; Controlled Study; Corpus Callosum; Data; Delusions; Detection; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Dorsal; Ear; Emotional; Emotions; Episodic memory; Event-Related Potentials; Evolution; Exhibits; Fiber; Functional disorder; Funding; Gender; General Population; Genes; Genetic; Goals; Grant; Hallucinations; Hand; Handedness; Health; Health Care Costs; Hospitalization; Image; Imaging Device; Imaging Techniques; Imaging technology; Immigration; Individual; Inferior; Inpatients; Internal Capsule; Investigation; Joystick; Lead; Left; Lesion; Letters; Light; Limb structure; Link; Literature; Lobule; Location; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Matched Group; Measures; Medial; Medical; Memory; Metabolism; Mission; Modeling; Monitor; Motor; Movement; Myelin; Myelin Sheath; N-Methylaspartate; Nature; Neurobehavioral Manifestations; Neuroglia; Neurologic; Neurons; Oligodendroglia; Onset of illness; Optics; Outpatients; Paranoia; Parietal; Participant; Patients; Performance; Pharmaceutical Preparations; Plague; Play; Prefrontal Cortex; Process; Progress Reports; Proteins; Psyche structure; Publications; Publishing; Radiation; Recording of previous events; Regulation; Relative (related person); Reporting; Research Design; Role; Sampling; Sampling Studies; Scanning; Schizophrenia; Secondary to; Semantics; Sensory; Severities; Short-Term Memory; Signal Transduction; Site; Socioeconomic Status; Somatosensory Cortex; Speech; Staging; Stimulus; Structure; Study Subject; Superior temporal gyrus; Susceptibility Gene; Symptoms; Synapses; System; Temporal Lobe; Testing; Thalamic structure; Time; Trail Making Test; Verbal Learning; Visual attention; Visual evoked cortical potential; Visuospatial; Water Movements; Work; base; cingulate cortex; cognitive function; cost; experience; follow-up; foster care; frontal lobe; gray matter; human subject; improved; in vivo; interest; interhemispheric transfer; language processing; longitudinal design; memory retrieval; morphometry; neural circuit; neuroimaging; neuropathology; neuropsychological; neurotransmission; new technology; novel; performance tests; physical property; processing speed; programs; progression marker; public health relevance; relating to nervous system; semantic processing; social cognition; spinal tract; synaptic function; tool; visual information; visual memory; white matter; white matter change

DESCRIPTION (provided by applicant): The long-term objective of this proposal is to understand the nature of brain abnormalities in schizophrenia by applying in vivo neuroimaging tools from the rapidly developing field of neuroimaging. The short-term objective is to evaluate white matter abnormalities using Magnetic Resonance (MR) Diffusion Tensor Imaging (DTI), a relatively new neuroimaging tool that reveals the physical properties of white matter. Of particular note, this new imaging tool is the only in vivo tool available to evaluate white matter fiber bundle abnormalities in schizophrenia, and, while plagued by problems expected in a new field of inquiry, it is still the most promising and powerful tool available to evaluate white matter alterations in schizophrenia. This imaging technique will be used to investigate white matter abnormalities in fronto-temporal white matter connections, interhemispheric white matter connections, thalamo-frontal fiber tracts, and frontal-parietal white matter connections. The subject sample will be right-handed patients with schizophrenia (both chronic and first episode) and age, gender, handedness, and parental socioeconomic status group matched controls. The study sample will be comprised of 50 chronic patients,110 first episode patients, and 160 controls studied at baseline over the 5 year grant period, and 50 first episode and 50 controls studied again at follow up one year later. MR DTI region of interest and tractography measures will be used to quantify anisotropic diffusion (degree of directionality of water movement, measured as fractional anisotropy) and diffusivity (average diffusion in all directions) in the aforementioned fiber bundles. Longitudinal changes will also be evaluated one year later in first episode patients and controls in order to determine progressive changes in white matter over this time period in first episode patients compared with controls. Specific predictions are made with respect to cognitive and DTI abnormalities (e.g., correlations between semantic priming abnormalities and arcuate fasciculus abnormalities). In addition another measure of white matter health and integrity, the interhemispheric transfer time task (IHTT), will be included in a visual evoked potential study, where it is predicted that IHTT efficiency will be compromised in schizophrenia. It is also predicted that longer IHTT, and decreased asymmetry, will be correlated with DTI measures in posterior portions of the corpus callosum, the largest white matter tract in the brain, which, in turn, will be correlated with measures of speed of processing. A longitudinal design is also a part of the IHTT measures, i.e., first episode patients and controls will be evaluated one year later. The investigation of MR DTI in schizophrenia will lead to a further understanding of white matter fiber tract abnormalities in this disorder, which will add a key link to understanding the neuropathology of schizophrenia, and ultimately to better and more rational treatment. PUBLIC HEALTH RELEVANCE: Schizophrenia is a devastating disorder that affects close to 1% of the general population and 40% of all VA mental healthcare costs (http://www.va.gov). Understanding this disorder is thus critical to the VA mission. Magnetic Resonance (MR) Diffusion Tensor Imaging (DTI) will be used to investigate white matter (WM) brain abnormalities in schizophrenia. Heretofore, conventional MR findings reported gray matter abnormalities, but few studies reported WM abnormalities. With the advent of DTI, WM tracts important to schizophrenia can now be investigated. DTI images will be acquired from chronic and first-episode patients, as well as controls. A measure of processing speed will also be included and relevant cognitive and symptom measures will be evaluated to determine associations among WM, cognitive abnormalities, clinical symptoms, and processing speed. This proposal will lead to new findings regarding WM abnormalities and cognitive and clinical correlates, which, in turn, will ultimately lead to better and more rationale treatment of this devastating disorder.

描述（由申请人提供）： 这项建议的长期目标是了解精神分裂症的大脑异常的性质，通过应用体内神经成像工具，从迅速发展的神经成像领域。短期目标是使用磁共振（MR）扩散张量成像（DTI）评价白色物质异常，这是一种相对较新的神经成像工具，可显示白色物质的物理特性。特别值得注意的是，这种新的成像工具是唯一的体内工具，可用于评估精神分裂症的白色物质纤维束异常，虽然困扰的问题，预计在一个新的调查领域，它仍然是最有前途的和强大的工具，可用于评估精神分裂症的白色物质改变。该成像技术将用于研究额颞白色连接、纵裂白色连接、丘脑-额叶纤维束和额顶叶白色连接中的白色异常。受试者样本将是右利手精神分裂症患者（慢性和首次发作）以及年龄、性别、利手和父母社会经济地位组匹配的对照。研究样本将由50名慢性患者、110名首次发作患者和160名对照组成，在5年资助期内进行基线研究，并在一年后再次对50名首次发作患者和50名对照进行随访研究。MR DTI感兴趣区域和纤维束成像测量将用于量化上述纤维束中的各向异性扩散（水运动的方向性程度，测量为分数各向异性）和扩散率（所有方向的平均扩散）。还将在一年后评价首次发作患者和对照组的纵向变化，以确定与对照组相比，首次发作患者在这段时间内白色物质的进行性变化。针对认知和DTI异常进行特定预测（例如，语义启动异常和弓状束异常之间的相关性）。此外，白色物质健康和完整性的另一项测量，即半球间转移时间任务（IHTT），将被纳入视觉诱发电位研究，其中预测IHTT效率将在精神分裂症中受损。还预测较长的IHTT和减少的不对称性将与胼胝体后部的DTI测量相关，胼胝体是大脑中最大的白色物质束，这反过来将与处理速度的测量相关。纵向设计也是IHTT措施的一部分，即，一年后对首次发病的患者和对照组进行评估。对精神分裂症的磁共振弥散张量成像的研究将会导致对该疾病中白色物质纤维束异常的进一步了解，这将为理解精神分裂症的神经病理学增加一个关键环节，最终更好更合理的治疗。 公共卫生相关性： 精神分裂症是一种毁灭性的疾病，影响了近1%的普通人群和40%的所有VA精神卫生保健费用（http：www.va.gov）。因此，了解这种疾病是至关重要的VA使命。磁共振（MR）扩散张量成像（DTI）将用于研究精神分裂症患者的白色物质（WM）脑异常。因此，传统的MR表现报告灰质异常，但很少有研究报告WM异常。随着DTI的出现，WM束对精神分裂症的重要性现在可以调查。将从慢性和首次发作患者以及对照组中采集DTI图像。还将包括处理速度的测量，并将评价相关的认知和症状测量，以确定WM、认知异常、临床症状和处理速度之间的关联。这一建议将导致关于WM异常以及认知和临床相关性的新发现，这反过来又将最终导致对这种毁灭性疾病的更好和更合理的治疗。