CORE 3: IMAGING

核心 3：成像

• 批准号: 8136032
• 负责人: Martha E. Shenton
• 金额: $ 26.29万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136032
• 关键词: Affect; Arts; Brain; Clinical; Cognitive; Disease; General Population; Genetic; Health; Hormonal; Image; Imaging Techniques; Lead; Post Technic; Prevention strategy; Process; Research Personnel; Role; Schizophrenia; United States; Work; interest; neuroimaging; progression marker; tool

Neuroimaging studies have led to important findings with respect to brain abnormalities in schizophrenia. In fact we know more about schizophrenia in the last two decades than in the prior century, and this is largely due to the advent of new imaging techniques that have lead to an appreciation of the role of brain abnormalities in this disorder. The objective of the Imaging Core is to provide state-of-the-art neuroimaging techniques and post-processing tools to support the work of CIDAR projects and investigators interested in evaluating brain abnormalities in schizophrenia in conjunction with cognitive, clinical, hormonal, and electrophysiological abnormalities, as well as genetic influences, so as to understand better putative markers of progression in schizophrenia. Moreover, understanding what factors are associated with progression in schizophrenia will likely lead to more targeted treatments as well as to prevention strategies for this devastating disorder, which affects close to 1 % of the general population and is thus a major health problem in the United States.

神经影像学研究已经导致了精神分裂症患者大脑异常的重要发现。在 事实上，在过去的二十年里，我们对精神分裂症的了解比前世纪更多，这在很大程度上是因为 由于新的成像技术的出现， 这种疾病的异常。成像核心的目标是提供最先进的神经成像 技术和后处理工具，以支持CIDAR项目和调查人员的工作， 结合认知、临床、激素和 电生理异常，以及遗传影响，以便更好地了解推定的标记 精神分裂症的进展此外，了解哪些因素与进展有关， 精神分裂症可能会导致更有针对性的治疗以及预防策略 破坏性疾病，影响到近1%的总人口，因此是一个主要的健康问题 在美国