MRI and Neuropsychological Findings in Schizophrenia, ADHD and Healthy Controls

精神分裂症、多动症和健康对照的 MRI 和神经心理学发现

• 批准号: 7813838
• 负责人: Martha E. Shenton
• 金额: $ 3.15万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7813838
• 关键词: Adult; Age; Amygdaloid structure; Anterior; Arts; Attention; Attention deficit hyperactivity disorder; Boston; Brain; Brain region; Cell Nucleus; Characteristics; Collaborations; Complex; Control Groups; Corpus Callosum; Country; DSM-IV; Development; Developmental Disabilities; Diffusion Magnetic Resonance Imaging; Dorsal; Education; Evaluation; Fiber; First Degree Relative; Functional disorder; Funding; Gender; Genetic; Goals; Grant; Hippocampus (Brain); Hospitals; Image; Image Analysis; Intelligence; Internal Capsule; International; Laboratories; Light; Limb structure; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Medial; Mediating; Meleagris gallopavo; Memory; Mental Health; Methods; National Institute of Mental Health; Nature; Neurobiology; Parents; Patients; Pediatric Hospitals; Performance; Phenotype; Prefrontal Cortex; Published Comment; Relative (related person); Research; Research Methodology; Research Personnel; Research Support; Research Training; Risk; Role; Scanning; Schizophrenia; Scientist; Short-Term Memory; Site; Societies; Sorting - Cell Movement; Structure; Structure-Activity Relationship; Subgroup; Superior temporal gyrus; Symptoms; System; Techniques; Technology; Testing; Thalamic structure; Training; Training Programs; Turkey bird; United States National Institutes of Health; Variant; Verbal Learning; Wisconsin; Woman; Work; Writing; base; behavioral/social science; biomedical scientist; brain volume; cingulate gyrus; cognitive function; comparative; computerized; executive function; experience; global health; gray matter; high risk; indexing; innovation; interest; neuroimaging; neuropsychological; parent grant; performance tests; proband; programs; psychologic; public health relevance; research and development; transmission process; visual memory; white matter

DESCRIPTION (provided by applicant): The Psychiatric Imaging Laboratory at the Brigham and Women's Hospital (Dr. Shenton, Director; PI, NIMH R01 5R01MH050740-13), in collaboration with the ICOHRTA Research Training Program in International Mental Health & Developmental Disabilities (MH/DD) at the Children's Hospital Boston (Dr. Munir; PI; Fogarty D43 TW005807), is applying for an International Research Collaboration - Behavioral, Social Sciences (FIRCA-BSS) [R03] grant for Dr. Ozgur Oner of Ankara Diskapi Children's Hospital in Turkey. Dr. Oner has been a highly successful international ICOHRTA fellow. The research goal of this proposal is to facilitate the further development of collaborative research between NIH supported U.S. biomedical scientists and investigators in Turkey, a FIRCA eligible country. The scientific objectives include: (1) studies of prefrontal, hippocampus-amygdala, caudate and superior temporal gyrus volumes measured by Magnetic Resonance Imaging (MRI) in adult subjects with schizophrenia and their "high-risk" (HR) first-degree relatives, stratified with and without ADHD, compared to subjects with ADHD, and normal controls; and (2) studies of the relation of neuropsychological executive, and attentional characteristics with the aforementioned brain structures in each group. Previous studies have shown that HR relatives of subjects with schizophrenia have attentional problems predictive of the emergence of schizophrenia, which are concomitant with structural and functional brain abnormalities and dysregulation in the dopaminergic systems, which may, in turn, involve the presence of symptoms resembling the ADHD phenotype. Subjects with ADHD themselves present with functional and structural brain variations, particularly in right prefrontal cortex and caudate, and may have dopaminergic transmission abnormalities, as reflected by imaging and genetics studies. We will study 4 groups: (i) index subjects with DSM-IV schizophrenia (n=30); (ii) their non-psychotic first-degree relatives --the high-risk HR group stratified as HR with ADHD (HR-A) (n=20) and without HR-NA (n=20) DSM-IV ADHD; (iii) subjects with DSM-IV ADHD (n=30); and (iv) normal controls of similar age, gender, and parental education (n=30). Weschler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, Trailmaking Test A and B, Continuous Performance Test, and Weschler Memory Scale will be used to evaluate executive, memory and attention functions. The proposed study aims involve innovative approaches in comparative schizophrenia and ADHD risk research, as well as use of neuroimaging and psychological research methodologies and expertise under the direction of a leading center in the US that supports and builds upon already established and productive international research collaboration in Turkey. 7. PUBLIC HEALTH RELEVANCE: The proposed aims will provide access for a promising international investigator to new perspectives, innovative concepts and technologies in neuroimaging at a leading NIH supported US center. The proposed study will investigate important scientific topics relevant to global health, schizophrenia and ADHD, both of which cause significant burden on society globally.

描述（申请人提供）：布里格姆妇女医院精神病成像实验室（Shenton博士，主任; PI，NIMH R 01 5 R 01 MH 050740 -13），与波士顿儿童医院国际心理健康和发育障碍（MH/DD）的ICOHRTA研究培训计划合作（Munir博士; PI; Fogarty D43 TW 005807）正在为土耳其安卡拉Alpabi儿童医院的Ozgur Oner博士申请国际研究合作-行为，社会科学（FIRCA-BSS）[R 03]资助。Oner博士是一位非常成功的国际ICOHRTA研究员。该提案的研究目标是促进NIH支持的美国生物医学科学家和土耳其（FIRCA合格国家）研究人员之间的合作研究的进一步发展。科学目标包括：（1）通过磁共振成像（MRI）测量患有精神分裂症的成年受试者及其“高风险”（HR）一级亲属的前额、海马-杏仁核、尾状核和上级颞回体积的研究，与患有ADHD的受试者和正常对照者进行比较，分层为患有和不患有ADHD的受试者;（2）研究各组的神经心理执行和注意特征与上述脑结构的关系。先前的研究表明，精神分裂症患者的HR亲属具有预测精神分裂症出现的注意力问题，这伴随着多巴胺能系统的结构和功能性脑异常和失调，这反过来可能涉及类似ADHD表型的症状的存在。ADHD受试者本身存在功能和结构性脑变化，特别是在右前额叶皮层和尾状核，并且可能具有多巴胺能传递异常，如成像和遗传学研究所反映的。我们将研究4组：（i）DSM-IV精神分裂症的索引受试者（n=30）;（ii）他们的非精神病一级亲属--高风险HR组，分层为HR伴ADHD（HR-A）（n=20）和无HR-NA（n=20）DSM-IV ADHD;（iii）DSM-IV ADHD受试者（n=30）;（iv）年龄、性别和父母教育程度相似的正常对照（n=30）。将使用Weschler成人智力量表修订版、威斯康星州卡片分类测试、线索形成测试A和B、持续表现测试和Weschler记忆量表评估执行、记忆和注意力功能。拟议的研究目标涉及比较精神分裂症和ADHD风险研究的创新方法，以及在美国领先中心的指导下使用神经影像学和心理学研究方法和专业知识，该中心支持并建立在已经建立的基础上土耳其富有成效的国际研究合作。7.公共卫生相关性：拟议的目标将提供一个有前途的国际研究人员在美国国立卫生研究院支持的美国领先中心的神经影像学的新观点，创新概念和技术的访问。这项拟议的研究将调查与全球健康、精神分裂症和多动症相关的重要科学课题，这两种疾病都给全球社会造成了重大负担。