Training in the Biology of Injury and Inflammation

描述（由申请人提供）：损伤和炎症是多种病理生理状态的核心组成部分，如败血症、创伤、出血、全身炎症反应综合征、关节炎和动脉粥样硬化。损伤和炎症的生物学在疾病状态中有许多共同的主题。虽然创伤最初被认为是外科医生的领域，关节炎是风湿病学家的范围，动脉粥样硬化是心脏病学家的重点，但这些过程仅仅代表了伴随宿主炎症反应的损伤的具体例子。事实上，许多这些疾病的分子和细胞基础是高度相似的。这些生物学问题非常复杂，需要在免疫学、细胞生物学、生物化学和分子生物学方面运用复杂的技术。跨越传统科学和临床学科的界限来解决这些损伤和炎症问题，需要未来的研究人员在多学科环境中接受培训，有机会实现思想和技术的交叉受精。这项损伤和炎症生物学培训基金的目的是为创伤、败血症、缺血/再灌注、急性和慢性炎症和/或危重疾病等临床状态的细胞和分子生物学提供博士后研究培训。我们计划每年资助4名学员。每位受训者将有至少两年的博士后研究时间。这个应用程序代表了一个多学科的研究训练计划，它从免疫学、生物化学、遗传学和生物医学工程等基础科学部门，以及医学、麻醉学和外科的临床部门中汲取灵感。虽然这项资助将被安置在杜克大学外科学系，但欢迎对麻醉学、医学或基础科学感兴趣的个人申请。该计划的核心目的是培养未来的损伤和炎症生物学科学家。

DESCRIPTION (provided by applicant): Injury and inflammation are central components of a variety of pathophysiologic states, such as sepsis, trauma, hemorrhage, systemic inflammatory response syndrome, arthritis and atherosclerosis. The biology of injury and inflammation shares many common themes across disease states. While trauma was initially deemed to be the realm of the surgeon, arthritis the purview of the rheumatologist, and atherosclerosis the focus for the cardiologist, these processes merely represent specific examples of injury with an accompanying host inflammatory response. Indeed, the molecular and cellular basis for many of these disorders are highly analogous. These biological questions are sufficiently complex that sophisticated techniques in immunology, ceil biology, biochemistry, and molecular biology are required. Crossing the boundaries of traditional scientific and clinical disciplines to address these issues of injury and inflammation will require that future researchers are trained in a multi-disciplinary environment with the opportunity for cross fertilization of ideas and technologies. The purpose of this training grant in the Biology of Injury and Inflammation is to provide postdoctoral research training in the cellular and molecular biology of clinical states typified by trauma, sepsis, ischemia/reperfusion, acute and chronic inflammation, and/or critical illness. We are proposing to support 4 total trainees per year. Each trainee will spend at least two years as apostdoctoral research fellow. This application represents a multidisciplinary research training program which draws from the basic science departments of Immunology, Biochemistry, Genetics, and Biomedical Engineering, as well as the clinical departments of Medicine, Anesthesiology, and Surgery. Although this grant will be housed in the Duke Dept. of Surgery, applications from interested individuals in Anesthesiology, Medicine or the basic sciences are welcome. The central intent of this program is to train future scientists in the Biology of Injury and Inflammation. Relevance: It is our goal to capitalize upon the scientific opportunities and resources available through Duke University by training future leaders in the biology of injury and inflammation.