Training in the Biology of Injury and Inflammation

损伤和炎症生物学培训

• 批准号: 8127659
• 负责人: Jeffrey H. Lawson
• 金额: $ 12.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127659
• 关键词: Biology; Inflammation; Injury; Training

DESCRIPTION (provided by applicant): Injury and inflammation are central components of a variety of pathophysiologic states, such as sepsis, trauma, hemorrhage, systemic inflammatory response syndrome, arthritis and atherosclerosis. The biology of injury and inflammation shares many common themes across disease states. While trauma was initially deemed to be the realm of the surgeon, arthritis the purview of the rheumatologist, and atherosclerosis the focus for the cardiologist, these processes merely represent specific examples of injury with an accompanying host inflammatory response. Indeed, the molecular and cellular basis for many of these disorders are highly analogous. These biological questions are sufficiently complex that sophisticated techniques in immunology, ceil biology, biochemistry, and molecular biology are required. Crossing the boundaries of traditional scientific and clinical disciplines to address these issues of injury and inflammation will require that future researchers are trained in a multi-disciplinary environment with the opportunity for cross fertilization of ideas and technologies. The purpose of this training grant in the Biology of Injury and Inflammation is to provide postdoctoral research training in the cellular and molecular biology of clinical states typified by trauma, sepsis, ischemia/reperfusion, acute and chronic inflammation, and/or critical illness. We are proposing to support 4 total trainees per year. Each trainee will spend at least two years as apostdoctoral research fellow. This application represents a multidisciplinary research training program which draws from the basic science departments of Immunology, Biochemistry, Genetics, and Biomedical Engineering, as well as the clinical departments of Medicine, Anesthesiology, and Surgery. Although this grant will be housed in the Duke Dept. of Surgery, applications from interested individuals in Anesthesiology, Medicine or the basic sciences are welcome. The central intent of this program is to train future scientists in the Biology of Injury and Inflammation. Relevance: It is our goal to capitalize upon the scientific opportunities and resources available through Duke University by training future leaders in the biology of injury and inflammation.

描述（由申请人提供）：损伤和炎症是多种病理生理状态的中心组成部分，如败血症、创伤、出血、全身炎症反应综合征、关节炎和动脉粥样硬化。损伤和炎症的生物学在疾病状态中有许多共同的主题。虽然创伤最初被认为是外科医生的领域，关节炎是风湿病学家的范围，动脉粥样硬化是心脏病学家的重点，但这些过程仅仅代表了伴随宿主炎症反应的损伤的具体例子。事实上，许多这些疾病的分子和细胞基础是高度相似的。这些生物学问题非常复杂，需要免疫学、细胞生物学、生物化学和分子生物学方面的尖端技术。跨越传统科学和临床学科的界限来解决这些损伤和炎症问题，将需要未来的研究人员在多学科环境中接受培训，并有机会进行思想和技术的交叉交流。在损伤和炎症的生物学这个培训补助金的目的是提供博士后研究培训的细胞和分子生物学的临床状态典型的创伤，败血症，缺血/再灌注，急性和慢性炎症，和/或危重病。我们建议每年总共支持4名受训人员。每个实习生至少要做两年的博士后研究员。该申请代表了一个多学科的研究培训计划，来自免疫学，生物化学，遗传学和生物医学工程的基础科学部门，以及医学，麻醉学和外科的临床部门。虽然这笔赠款将被安置在杜克系。欢迎对麻醉学、医学或基础科学感兴趣的个人申请。该计划的中心目的是培养未来的科学家在损伤和炎症的生物学。 相关性：我们的目标是利用杜克大学提供的科学机会和资源，培养未来的损伤和炎症生物学领导者。