Training in the Biology of Injury and Inflammation
损伤和炎症生物学培训
基本信息
- 批准号:8299640
- 负责人:
- 金额:$ 12.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-07-01 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Injury and inflammation are central components of a variety of pathophysiologic states, such as sepsis,
trauma, hemorrhage, systemic inflammatory response syndrome, arthritis and atherosclerosis. The biology
of injury and inflammation shares many common themes across disease states. While trauma was initially
deemed to be the realm of the surgeon, arthritis the purview of the rheumatologist, and atherosclerosisthe
focus for the cardiologist, these processes merely represent specific examples of injury with an
accompanying host inflammatory response. Indeed, the molecular and cellular basis for many of these
disorders are highly analogous. These biological questions are sufficiently complex that sophisticated
techniques in immunology, ceil biology, biochemistry, and molecular biology are required. Crossing the
boundaries of traditional scientific and clinical disciplines to address these issues of injury and inflammation
will require that future researchers are trained in a multi-disciplinary environment with the opportunity for
cross fertilization of ideas and technologies. The purpose of this training grant in the Biology of Injury and
Inflammation is to provide postdoctoral research training in the cellular and molecular biology of clinical
states typified by trauma, sepsis, ischemia/reperfusion, acute and chronic inflammation, and/or critical
illness. We are proposing to support 4 total trainees per year. Each trainee will spend at least two years as a
postdoctoral research fellow. This application represents a multidisciplinary research training program which
draws from the basic science departments of Immunology, Biochemistry, Genetics, and Biomedical
Engineering, as well as the clinical departments of Medicine, Anesthesiology, and Surgery. Although this
grant will be housed in the Duke Dept. of Surgery, applications from interested individuals in Anesthesiology,
Medicine or the basic sciences are welcome. The central intent of this program is to train future scientists in
the Biology of Injury and Inflammation.
It is our goal to capitalize upon the scientific opportunities and resources available through Duke University
by training future leaders in the biology of injury and inflammation.
损伤和炎症是多种病理生理状态的核心组成部分,例如脓毒症、
创伤、出血、全身炎症反应综合征、关节炎和动脉粥样硬化。生物学
损伤和炎症在不同疾病状态下有许多共同的主题。虽然创伤最初是
关节炎被认为是外科医生的领域,关节炎被认为是风湿病学家的领域,而动脉粥样硬化被认为是外科医生的领域。
对于心脏病专家来说,这些过程仅代表了因心脏病引起的损伤的具体例子
伴随宿主炎症反应。事实上,其中许多的分子和细胞基础
疾病是高度相似的。这些生物学问题足够复杂,以至于复杂
需要免疫学、细胞生物学、生物化学和分子生物学技术。穿越
突破传统科学和临床学科的界限来解决这些损伤和炎症问题
将要求未来的研究人员在多学科环境中接受培训,并有机会
思想和技术的交叉融合。损伤生物学培训补助金的目的
炎症是提供临床细胞和分子生物学的博士后研究培训
以创伤、败血症、缺血/再灌注、急性和慢性炎症和/或危重为代表的状态
疾病。我们建议每年支持 4 名学员。每位学员将至少花费两年的时间作为
博士后研究员。该应用程序代表了一个多学科研究培训计划,
来自免疫学、生物化学、遗传学和生物医学等基础科学部门
工程以及医学、麻醉学和外科临床部门。虽然这
拨款将设在杜克大学外科系,来自麻醉学领域感兴趣的个人的申请,
欢迎医学或基础科学。该计划的中心目的是培训未来的科学家
损伤和炎症生物学。
我们的目标是利用杜克大学提供的科学机会和资源
通过培训损伤和炎症生物学领域的未来领导者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey H. Lawson其他文献
Sauvetage d’un accès vasculaire et traitement d’un œdème grave du membre : Rapport de cas sur l’utilisation originale du dispositif d’accès vasculaire Hemodialysis Reliable Outflow
Sauvetage d’un accès vasculaire et Traeement d’un œdèmegrave du membre : Rapport de cas sur l’utilise Originale du dispositif d’accès vasculaire Hemodialysis Reliable Outflow
- DOI:
10.1016/j.acvfr.2012.02.002 - 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Shawn M. Gage;Hardeep S. Ahluwalia;Jeffrey H. Lawson - 通讯作者:
Jeffrey H. Lawson
Blocking the Initiation of Coagulation by RNA Aptamers to Factor VIIa
阻断因子 VIIa 的 RNA 适体的凝血起始
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:6.7
- 作者:
C. Rusconi;Alice Yeh;H. Lyerly;Jeffrey H. Lawson;B. Sullenger - 通讯作者:
B. Sullenger
Genetic modification of endothelial cells to improve vascular graft function
- DOI:
10.1016/j.jamcollsurg.2005.06.231 - 发表时间:
2005-09-01 - 期刊:
- 影响因子:
- 作者:
Kelley A. Hutcheson;Dana M. Giangiacomo;Jeffrey H. Lawson - 通讯作者:
Jeffrey H. Lawson
Gene expression profiling to describe and model peripheral arterial disease
- DOI:
10.1016/j.jamcollsurg.2005.06.076 - 发表时间:
2005-09-01 - 期刊:
- 影响因子:
- 作者:
David C. Evans;Aamir Zakaria;John L. Gray;Jeffrey H. Lawson - 通讯作者:
Jeffrey H. Lawson
Insignificant blood damage in calves with a total artificial heart up to six months.
使用全人工心脏的小牛在六个月内不会出现明显的血液损伤。
- DOI:
- 发表时间:
1978 - 期刊:
- 影响因子:0
- 作者:
Razzeca Kj;Hodges Mr;Peters Jl;Fumio Iwaya;H. Fukumasu;Don B. Olsen;Jeffrey H. Lawson;Kolff Wj - 通讯作者:
Kolff Wj
Jeffrey H. Lawson的其他文献
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{{ truncateString('Jeffrey H. Lawson', 18)}}的其他基金
Exercise, Nitric Oxide Bioavailability and Arteriovenous Fistula Maturation
运动、一氧化氮生物利用度和动静脉瘘成熟
- 批准号:
8890833 - 财政年份:2014
- 资助金额:
$ 12.76万 - 项目类别:
Exercise, Nitric Oxide Bioavailability and Arteriovenous Fistula Maturation
运动、一氧化氮生物利用度和动静脉瘘成熟
- 批准号:
8771393 - 财政年份:2014
- 资助金额:
$ 12.76万 - 项目类别:
Autologous EPC lining to improve biocompatibility of circulatory assist devices
自体 EPC 衬里可提高循环辅助装置的生物相容性
- 批准号:
7933924 - 财政年份:2009
- 资助金额:
$ 12.76万 - 项目类别:
Autologous EPC lining to improve biocompatibility of circulatory assist devices
自体 EPC 衬里可提高循环辅助装置的生物相容性
- 批准号:
7821745 - 财政年份:2009
- 资助金额:
$ 12.76万 - 项目类别:
Training in the Biology of Injury and Inflammation
损伤和炎症生物学培训
- 批准号:
8127659 - 财政年份:2004
- 资助金额:
$ 12.76万 - 项目类别:
Training in the Biology of Injury and Inflammation
损伤和炎症生物学培训
- 批准号:
8500342 - 财政年份:2004
- 资助金额:
$ 12.76万 - 项目类别:
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