Training in the Biology of Injury and Inflammation

损伤和炎症是各种病理生理状态的中心组成部分，如脓毒症， 创伤、出血、全身性炎症反应综合征、关节炎和动脉粥样硬化。生物学 在不同的疾病状态下，损伤和炎症有许多共同的主题。虽然创伤最初是 被认为是外科医生的领域，关节炎是风湿科医生的职权范围，动脉粥样硬化是 对于心脏病专家来说，这些过程只是代表了与 伴随宿主炎症反应。事实上，其中许多的分子和细胞基础 疾病是高度相似的。这些生物学问题足够复杂，以至于复杂到 需要掌握免疫学、细胞生物学、生物化学和分子生物学方面的技术。跨过 传统科学和临床学科的界限，以解决这些损伤和炎症问题 将要求未来的研究人员在多学科环境中接受培训，并有机会 思想和技术的交叉培养。这笔培训补助金的目的是为了在损伤和生物医学方面 炎症是提供临床细胞和分子生物学方面的博士后研究培训 以创伤、脓毒症、缺血/再灌流、急性和慢性炎症和/或危重为特征的状态 生病了。我们建议每年总共支持4名学员。每个实习生将至少有两年的时间作为 博士后研究员。该申请代表了一个多学科的研究培训计划 摘自免疫学、生物化学、遗传学和生物医学的基础科学系 工程学，以及内科、麻醉学和外科的临床部门。虽然这件事 格兰特将住在杜克部。手术，麻醉学感兴趣的个人的申请， 欢迎学习医学或基础科学。该计划的主要目的是培养未来的科学家 损伤和炎症的生物学。 我们的目标是利用杜克大学提供的科学机会和资源 通过在损伤和炎症的生物学方面培训未来的领导者。

Injury and inflammation are central components of a variety of pathophysiologic states, such as sepsis, trauma, hemorrhage, systemic inflammatory response syndrome, arthritis and atherosclerosis. The biology of injury and inflammation shares many common themes across disease states. While trauma was initially deemed to be the realm of the surgeon, arthritis the purview of the rheumatologist, and atherosclerosisthe focus for the cardiologist, these processes merely represent specific examples of injury with an accompanying host inflammatory response. Indeed, the molecular and cellular basis for many of these disorders are highly analogous. These biological questions are sufficiently complex that sophisticated techniques in immunology, ceil biology, biochemistry, and molecular biology are required. Crossing the boundaries of traditional scientific and clinical disciplines to address these issues of injury and inflammation will require that future researchers are trained in a multi-disciplinary environment with the opportunity for cross fertilization of ideas and technologies. The purpose of this training grant in the Biology of Injury and Inflammation is to provide postdoctoral research training in the cellular and molecular biology of clinical states typified by trauma, sepsis, ischemia/reperfusion, acute and chronic inflammation, and/or critical illness. We are proposing to support 4 total trainees per year. Each trainee will spend at least two years as a postdoctoral research fellow. This application represents a multidisciplinary research training program which draws from the basic science departments of Immunology, Biochemistry, Genetics, and Biomedical Engineering, as well as the clinical departments of Medicine, Anesthesiology, and Surgery. Although this grant will be housed in the Duke Dept. of Surgery, applications from interested individuals in Anesthesiology, Medicine or the basic sciences are welcome. The central intent of this program is to train future scientists in the Biology of Injury and Inflammation. It is our goal to capitalize upon the scientific opportunities and resources available through Duke University by training future leaders in the biology of injury and inflammation.