Training in the Biology of Injury and Inflammation

损伤和炎症是多种病理生理状态的中心组成部分，例如脓毒症， 创伤、出血、全身炎症反应综合征、关节炎和动脉粥样硬化。生物学 损伤和炎症在疾病状态中有许多共同的主题。虽然创伤最初是 被认为是外科医生的领域，关节炎是风湿病学家的领域，而动脉粥样硬化是 对于心脏病专家来说，这些过程仅仅是损伤的具体例子， 伴随宿主炎症反应。事实上，这些疾病的分子和细胞基础 疾病是高度相似的。这些生物学问题非常复杂， 需要免疫学、细胞生物学、生物化学和分子生物学方面的技术。穿越 传统科学和临床学科的界限，以解决这些问题的伤害和炎症 将要求未来的研究人员在多学科环境中接受培训， 思想和技术的相互促进。本培训补助金的目的是在伤害的生物学和 炎症是提供博士后研究培训的细胞和分子生物学的临床 以创伤、败血症、缺血/再灌注、急性和慢性炎症和/或危重疾病为代表的状态 病我们建议每年总共支持4名受训人员。每名受训人员将至少花两年时间， 博士后研究员。该应用程序代表了一个多学科的研究培训计划， 来自免疫学、生物化学、遗传学和生物医学等基础科学部门 工程，以及内科，麻醉科和外科的临床部门。虽然这 格兰特将被安置在杜克系。外科学，麻醉学感兴趣的个人的应用， 医学或基础科学是受欢迎的。该计划的主要目的是培养未来的科学家， 损伤和炎症的生物学。 我们的目标是利用杜克大学提供的科学机会和资源 通过培训未来的领导者在损伤和炎症的生物学。

Injury and inflammation are central components of a variety of pathophysiologic states, such as sepsis, trauma, hemorrhage, systemic inflammatory response syndrome, arthritis and atherosclerosis. The biology of injury and inflammation shares many common themes across disease states. While trauma was initially deemed to be the realm of the surgeon, arthritis the purview of the rheumatologist, and atherosclerosisthe focus for the cardiologist, these processes merely represent specific examples of injury with an accompanying host inflammatory response. Indeed, the molecular and cellular basis for many of these disorders are highly analogous. These biological questions are sufficiently complex that sophisticated techniques in immunology, ceil biology, biochemistry, and molecular biology are required. Crossing the boundaries of traditional scientific and clinical disciplines to address these issues of injury and inflammation will require that future researchers are trained in a multi-disciplinary environment with the opportunity for cross fertilization of ideas and technologies. The purpose of this training grant in the Biology of Injury and Inflammation is to provide postdoctoral research training in the cellular and molecular biology of clinical states typified by trauma, sepsis, ischemia/reperfusion, acute and chronic inflammation, and/or critical illness. We are proposing to support 4 total trainees per year. Each trainee will spend at least two years as a postdoctoral research fellow. This application represents a multidisciplinary research training program which draws from the basic science departments of Immunology, Biochemistry, Genetics, and Biomedical Engineering, as well as the clinical departments of Medicine, Anesthesiology, and Surgery. Although this grant will be housed in the Duke Dept. of Surgery, applications from interested individuals in Anesthesiology, Medicine or the basic sciences are welcome. The central intent of this program is to train future scientists in the Biology of Injury and Inflammation. It is our goal to capitalize upon the scientific opportunities and resources available through Duke University by training future leaders in the biology of injury and inflammation.