Molecular Biology and Gene Therapy in Burns and Trauma

烧伤和创伤的分子生物学和基因治疗

• 批准号: 8119660
• 负责人: LYLE L MOLDAWER
• 金额: $ 11.64万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119660
• 关键词: Burn Trauma; gene therapy

DESCRIPTION (provided by applicant): The overall goal of this existing training program is to provide a focused 2-3 year research experience for up to two clinical residents-in- training (predominantly in surgery) expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy, as it applies to inflammation research. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics, gene therapy and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. The interface between molecular biology and inflammation research will be targeted to ARDS, sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, The faculty will be drawn from funded basic scientists in the Surgery, Obstetrics/ Gynecology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Anesthesiology, Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology, taking advantage of Ph.D. programs available to them, if appropriate. Furthermore, trainees are expected to participate in seminars in the Powell Gene Therapy Center and Genetics Institute, and in their basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research. Relevance: Society recognizes the critical role that clinician-scientists play in translational biology and the application of new technologies to the clinic. We propose that a 2-3 year immersion by a young interested clinician in the laboratory of a successful basic scientist with expertise in molecular biology will provide a sound foundation for a career as a physician/scientist involved in translational research. The successful trainees will have the expertise in functional genomics, gene therapy and molecular biology to help translate the current genetic revolution to trauma practice.

描述（由申请人提供）：该现有培训计划的总体目标是为最多两名临床实习医生（主要是外科医生）提供为期2-3年的集中研究经验，表达对创伤，损伤，烧伤或炎症研究事业的承诺。该研究计划将侧重于掌握分子生物学，功能基因组学和基因治疗，因为它适用于炎症研究。该计划将利用医学院在功能基因组学，基因治疗和分子生物学领域的独特优势，以及致力于培养未来临床院士的基础科学家和临床医生之间的合作。分子生物学和炎症研究之间的接口将针对ARDS，脓毒症综合征，缺血/再灌注损伤，延迟伤口愈合和烧伤伤口，教师将从外科，产科/妇科，分子遗传学和微生物学部门的资助基础科学家中抽取，他们将担任学员的研究导师。来自外科、麻醉学、医学和病理学的临床导师 各部门将与学员和研究人员互动，以确保学员接触到炎症研究中的临床重要问题。该计划的总体方向将取决于主要研究者和执行委员会。该研究金的候选人将在全国范围内和从佛罗里达大学医学院招募。执行委员会的成功申请者将确定一名研究和临床导师，他将帮助制定正式的培训计划并定期审查受训者的进展。培训计划的大部分将在一位经验丰富的研究导师的实验室进行，但学员也将被要求完成研究伦理和统计方法的基本课程工作，并将被鼓励获得分子生物学的补充教学培训，利用博士学位。如果合适的话，可以提供给他们的方案。此外，受训人员还将参加鲍威尔基因治疗中心和遗传学研究所及其基础科学部门的研讨会以及实验室研究会议。他们还将参加临床研讨会，包括外科和重症监护医学大查房。预计成功的毕业生将拥有足够的研究技能，以竞争炎症研究的过渡资金。 相关性：社会认识到临床科学家在转化生物学和新技术应用于临床中发挥的关键作用。我们建议，2-3年的浸泡由一个年轻的有兴趣的临床医生在实验室的一个成功的基础科学家在分子生物学的专业知识将提供一个良好的基础，作为一个医生/科学家参与转化研究的职业生涯。成功的学员将拥有功能基因组学、基因治疗和分子生物学方面的专业知识，以帮助将当前的基因革命转化为创伤实践。