PROGRAM IN MOLECULAR BIOPHYSICS

分子生物物理学项目

• 批准号: 8091442
• 负责人: JULIETTE T LECOMTE
• 金额: $ 70.7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8091442
• 关键词: Biophysics; Molecular; programs

DESCRIPTION (provided by applicant): The Program in Molecular Biophysics (PMB) seeks to renew its training grant. Its goal is to train students thoroughly versed in the fundamental physical principles governing the structures, interactions, and functions of biological macromolecules and their complexes, and who are also cognizant of the current frontiers in biology and able to develop their research in biologically relevant terms. The Department of Biophysics (Arts & Sciences, Homewood campus) and the Department of Biophysics & Biophysical Chemistry (School of Medicine, East Baltimore campus) form the program core with respect to administration and curriculum; 42 faculty from 14 departments participate in training activities. The participating laboratories form a coherent group with a strong sense of community engendered by activities such as an annual retreat and a monthly evening Biophysical Discussion. Faculty and students also have access to shared instrumentation facilities for X-ray, ultracentrifuge, high field NMR, and mass spectrometry. Students freely move between campuses and laboratories for course work, rotations, and thesis research. Students with strong backgrounds in quantitative and physical sciences are recruited; most are familiar with biochemistry and molecular biology. In the first year, students take four core courses specifically designed for PMB; they cover thermodynamic and structural principles of molecular biophysics as well as relevant computational and experimental methods. Readings from the literature and computer programming exercises are extensively incorporated into class assignments, and the courses emphasize quantitative analysis and fundamental physical principles. First year students also complete three 10 week lab rotations and a lecture series on Responsible Conduct of Research. Students choose a lab for thesis research at the end of the second semester, and also must demonstrate proficiency in biochemistry and molecular and cellular biology in an oral exam. Second year students take Organic Mechanisms in Biology and two electives; present a formal seminar on a current topic in biophysics and take an oral qualifying exam. 16 trainees are currently supported by this grant, out of a total of 50 program students. RELEVANCE: Living cells and organisms ultimately depend on the complex interactions taking place between thousands of proteins, nucleic acids, and smaller molecules. In this training program, students learn to use the methods of physical sciences and computation to investigate this network of interactions, and how the molecular details of these interactions illuminate the underlying causes of specific diseases.

描述（由申请人提供）：分子生物物理学（PMB）计划寻求更新其培训补助金。它的目标是培养学生彻底精通的基本物理原理管理的结构，相互作用和生物大分子及其复合物的功能，谁也认识到在生物学的当前前沿，并能够在生物学相关方面发展自己的研究。生物物理学系（艺术与科学，霍姆伍德校区）和生物物理学与生物物理化学系（医学院，东巴尔的摩校区）形成了管理和课程的计划核心;来自14个部门的42名教师参加培训活动。参与的实验室形成了一个有凝聚力的团体，通过年度务虚会和每月一次的生物物理讨论会等活动产生了强烈的社区意识。教师和学生还可以使用共享的仪器设备，用于X射线，超离心，高场NMR和质谱分析。学生可以自由地在校园和实验室之间流动，进行课程作业、轮换和论文研究。 招收具有定量和物理科学背景的学生;大多数人熟悉生物化学和分子生物学。在第一年，学生参加专门为PMB设计的四门核心课程;它们涵盖分子生物物理学的热力学和结构原理以及相关的计算和实验方法。课堂作业中包含大量的文献阅读和计算机编程练习，课程强调定量分析和基本物理原理。一年级的学生还完成了三个10周的实验室轮换和一系列关于负责任的研究行为的讲座。学生在第二学期结束时选择一个实验室进行论文研究，并且必须在口试中展示生物化学和分子与细胞生物学的熟练程度。第二年的学生参加生物学中的有机机制和两门选修课;就生物物理学的一个当前主题举办一次正式研讨会，并参加一次口头资格考试。目前有16名受训人员得到这项赠款的支助，从50名学生中脱颖而出。相关性：活细胞和生物体最终依赖于数千种蛋白质、核酸和小分子之间发生的复杂相互作用。在这个培训计划中，学生学习使用物理科学和计算的方法来研究这种相互作用的网络，以及这些相互作用的分子细节如何阐明特定疾病的根本原因。