The Boston Area Diabetes Endocrinology Research Center

概述（由申请人提供）：波士顿地区糖尿病内分泌研究中心（BADERC）是一个由实验室和临床研究人员组成的联盟，致力于解决与1型和2型糖尿病及其相关微血管和动脉粥样硬化并发症的病因、发病机制、治疗和治愈有关的许多主要研究问题。中心主任（Joseph Avruch）和副主任（Joel F. Habener和Brian Seed）是在信号转导，基因表达，分子生物学和免疫学方面具有国际地位的高生产力高级研究员，这些主题是糖尿病研究进展的核心。参与研究的科学家来自波士顿地区的许多研究机构，包括哈佛医学院附属的主要教学医院（马萨诸塞州总医院、布里格姆妇女医院、贝斯以色列女祭司医疗中心）和哈佛医学院附属的研究机构（艺术与科学学院、公共卫生学院、舍本斯眼科研究所、丹娜法伯癌症研究所）、波士顿大学医学中心、新英格兰医学中心和麻省理工学院这些研究人员在与1型和2型糖尿病的发病机制和最佳治疗最相关的领域的前沿工作：胰岛素作用和胰岛素抵抗的分子和遗传基础；血管系统和朗格汉氏胰岛的生物学；自体免疫和移植排斥反应的免疫学基础及最佳治疗方法血糖监测和控制新方法的发展。

DESCRIPTION, OVERALL (provided by applicant): The Boston Area Diabetes Endocrinology Research Center (BADERC) is a consortium of laboratory-based and clinical investigators whose efforts are directed toward addressing many of the major research questions bearing on the etiology, pathogenesis, treatment and cure of type 1 and type 2 diabetes, and their associated microvascular and atherosclerotic complications. The center Director (Joseph Avruch and Associates Directors (Joel F. Habener and Brian Seed) are highly productive senior investigators of international stature in signal transduction, gene expression, molecular biology and immunology, topics central to advances in diabetes research. The participating scientists are based at a large number of Boston-area research institutions, including the major Harvard Medical School-affiliated teaching hospitals (the Massachusetts General Hospital, the Brigham and Women's Hospital, the Beth Israel-Deaconess Medical Center) and Harvard-affiliated research institutions (the School of Arts and Sciences, School of Public Health, the Scheppens Eye Research Institute, Dana-Farber Cancer Institute), the Boston University Medical Center, the New England Medical Center and the Massachusetts Institute of Technology. These investigators are working at the cutting edge of fields most relevant to defining the pathogenesis and optimal treatment of type 1 and type 2 diabetes: The molecular and genetic basis of insulin action and insulin resistance; the biology of the vascular system and islet of Langerhan's; the immunologic basis and optimal therapies for autoimmunity and transplant rejection; the development of new methods for glycemic monitoring and control. The BADERC offers these scientists an array of core support services (Molecular Biology, Cell Biology/Morphology, Transgenics, Immunology/Flow Cytometry and Metabolic Physiology) that incorporate the latest technical advances in molecular genetics, cell biology, and metabolic physiology provided by acknowledged experts. In the coming interval, facilitated access for BADERC investigators to several platforms of the Broad institute has been arranged (Genetic Analysis, Proteomics, Metabolomics and RNAi). Most BADERC cores are heavily oriented towards hands-on training. The BADERC also supports a highly subscribed pilot and feasibility grant program. The easy access to cost effective support services of outstanding quality together with the educational and pilot grants program has promoted many collaborations, and attracted to diabetes research new talent from this outstanding scientific community. Finally, it is a goal of the center to foster the closest interactions between the laboratory based and clinical scientists, so as to ensure the translation of research discoveries into advances in the care of diabetic patients.