Neuroscience Imaging Center at OHSU

我们建议在OHSU建立一个神经科学成像中心，该中心将提供最先进的电子、荧光和共聚焦显微镜仪器，以及设计和分析成像实验的专业知识。神经科学成像中心将有3个核心：1)活细胞成像核心，2)共焦核心，3)EM核心。OHSU已经拥有建立这些核心所需的主要仪器和专业知识。然而，这些显微镜缺乏配备齐全的核心，阻碍了NINDS调查人员有效和可靠地使用这些仪器。神经科学成像中心将为这些显微镜提供专门的工作人员，以加强和促进OHSU NINDS调查人员的研究。一个咨询委员会将在行政核心的协助下监督中心的运作，审查和优化构成核心的效力，并管理中心的财务方面。这三个核心将作为一个真正的集成设施发挥作用，从实验设计到性能，再到数据分析。仪器资源将位于西区和马奎姆山校区，从而为整个OHSU神经科学界服务。Sue Aicher博士和Gary Banker博士将担任该中心的联席主任；每一位主任都具有独特的科学和技术资历以及管理共享设施的经验。中心主任将为研究人员提供前端咨询，提炼实验问题，并为个别实验制定最佳技术方法。三名核心管理人员和技术人员将操作主要仪器，培训新用户，并为一些调查人员提供全方位服务的实验。培训机会将提供给首席研究员、博士后研究员和研究生。神经科学是OHSU研究的核心；成像中心将把尖端成像技术带给本提案中确定的23个NINDS资助的研究项目，以及我们NINDS资助的受训人员。神经科学成像中心将在我们整个神经科学界内促进有重点的互动。

We propose to establish a Neuroscience Imaging Center at OHSU that will provide state-of-the-art instrumentation for electron, fluorescent, and confocal microscopy as well as expertise in designing and analyzing imaging experiments. The Neuroscience Imaging Center will have 3 cores: 1) a Live-cell Imaging Core, 2) a Confocal Core, and 3) an EM Core. The major instrumentation and expertise necessary for establishing these cores exist already at OHSU. However, the lack of fully staffed cores for these microscopes prevents efficient and reliable use of these instruments by NINDS investigators. The Neuroscience Imaging Center will provide the dedicated staff for these microscopes to enhance and facilitate the research by NINDS investigators at OHSU. An advisory committee, aided by an administrative core, will oversee the operations of the Center, review and optimize the effectiveness of the component cores, and manage the fiscal aspects of the Center. The three cores will function together as a truly integrated facility from experimental design, to performance, to data analysis. Instrumentation resources will be located on both the West and Marquam Hill campuses, thereby serving the entire OHSU neuroscience community. Drs. Sue Aicher and Gary Banker will serve as co-Directors of the Center; each Director brings unique scientific and technical qualifications and experience in managing shared facilities. The Center Directors will provide front-end consultation with the investigators, refining experimental questions and formulating optimal technical approaches for individual experiments. Three Core Managers and technical staff will operate the major instrumentation, train new users, and provide full service experiments for some investigators. Training opportunities will be available to serve principal investigators, postdoctoral fellows, and graduate students. Neuroscience is the centerpiece of research at OHSU; the Imaging Center will bring cutting-edge imaging to the 23 NINDS-funded research programs identified in this proposal, as well as our NINDS-funded trainees. The Neuroscience Imaging Center will catalyze focused interactions within our entire neuroscience community.