In Vivo Cellular and Molecular Imaging Centers (ICMICs)

体内细胞和分子成像中心 (ICMIC)

• 批准号: 8147595
• 负责人: ROBERT F MATTREY
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-23 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8147595
• 关键词: Animal Model; Award; California; Cancer Center; Cells; Clinical Trials; Commit; Contrast Media; Development; Diagnostic Neoplasm Staging; Disease; Drug Kinetics; Drug effect disorder; Emulsions; Enzyme Inhibition; Enzymes; Equipment; Faculty; Fluorocarbon Emulsions; Funding; Gene Delivery; Goals; Housing; Human Resources; Image; Indolent; Interdisciplinary Study; Label; Lesion; Malignant Neoplasms; Matrix Metalloproteinases; Medicine; Mentors; Molecular; Molecular Biology; Molecular Target; Pathology; Pathway interactions; Patients; Platinum; Polymers; Positron-Emission Tomography; Research; Research Personnel; Resistance; Rodent; Seasons; Side; System; TNFRSF5 gene; Therapeutic; Therapeutic Effect; Therapeutic Index; Therapeutic Intervention; Time; Training; Ultrasonography; United States National Institutes of Health; Vitamin B 12; angiogenesis; base; cancer stem cell; career development; in vivo; in vivo Cellular and Molecular Imaging Centers; interest; molecular imaging; nanoparticle; novel diagnostics; optical imaging; receptor; self assembly; single photon emission computed tomography; synergism; tool; tumor

The Unviersity of California, San Diego is committed to developing in-vivo imaging at the molecular and cellular level to answer basic molecular biology questions, to determine the molecular basis of drug action, interaction and resistance, to assess the effect of therapeutic interventions and to probe unique animal models at the molecular level of disease in general, and cancer in particular. The ultimate goal is to develop new diagnostic and therapeutic tools to detect and distinguish aggressive from indolent lesions in order to treat patients at the early stages of cancer development. Also critical is to assess therapeutic effects when therapy is directed at molecular targets such as enzyme inhibition or interference with specific pathways. The centralized space in the new Moores UCSD Cancer Center (MCC) that also houses our rodent imaging facility adjacent to the vivarium will group the ICMIC team with other cancer investigators. We have built the ICMIC along side the NCI funded NanoTumor Center within the MCC to maximize efficiency and synergism. The P20 award 5 years ago began our multidisciplinary collaboration. Over the last five years we have submitted more than 10 new ideas as R01-type projects in the P50s and many development projects in the P20 and P50 submissions. Eight of those ideas (7 for projects and 1 developmental project) have now been funded by the NIH, DOD, or DOE. We present here 5 new projects and one that was submitted previously that has been revised. The projects submitted in this P50 application focus on the interface between imaging and therapy. Project 1 aims to detect matrix metalloproteinase in tumors, a sign of tumor aggressiveness, with ultrasound contrast agents. They plan to take advantage of the fact that fluorocarbon emulsions are visible only when combined to induce aggregation at the time the emulsion is exposed to the enzyme of interest. Project 2 aims to label a platinum carrying polymer for PET and SPECT imaging of a cancer chemotherapeutic currently in clinical trial. Their goal is to provide the clinicians with drug kinetics and propose to increase the agent's therapeutic index by targeting it as the vitamin B-12 receptor. Project 3 proposes a clever nanoparticle self-assembly system to target angiogenesis, also a sign of tumor aggressiveness, for imaging and therapy. The Developmental Projects represent cutting edge research that focus on cell labeling, gene delivery, and optical imaging of stem cell cancers. We also focus this ICMIC on Career Development and present three applicants for training in molecular imaging. The P.l.s of one major project and all 3 Developmental Projects are junior faculty from Pathology (1), Medicine (3) and the Cancer Center (1) that are mentored by seasoned investigators. The Institutional support is significant. We have been provided prime space in the cancer center, all rodent imaging equipment are located in the cancer center adjacent to the vivarium, and key personnel.

加州大学圣地亚哥分校致力于在分子和细胞水平上发展体内成像，以回答基本的分子生物学问题，确定药物作用、相互作用和耐药性的分子基础，评估治疗干预的效果，并在一般疾病，特别是癌症的分子水平上探索独特的动物模型。最终目标是开发新的诊断和治疗工具来检测和区分侵袭性和惰性病变，以便在癌症发展的早期阶段治疗患者。同样重要的是评估治疗效果，当