Developmental Projects

发展项目和资金 总预算：12万美元/年。 如前所述，本报告提议的120 000美元并不是固定的。它可以增加也可以减少。 取决于需要、可用资金、项目组合中的可用项目和方案监督。 发展资金将从普通资金池中获得支持，并通过 癌症中心和其他内部和外部资金来源。 这里展示的三个项目是《科学评论》排名最高的三个项目 委员会审查了8个1页的摘要以纳入本文件。提交的三份文件中有两份 去年再次被选入榜单。委员会认为，它们的科学和临床影响是 没有充分地呈现。去年提交的第三个项目是国防部最近提供的资金。确实是 取而代之的是一份由干细胞肿瘤发病率上升所提交的预测。 正如强调的那样，如果P50获奖，这三个项目可能不是我们将提供资金的项目。vt.在.的基础上 释放资金，科学指导委员会将再次征集意见书，并将审查 并为指导委员会需要的资金选择最合适和排名最高的项目 批准。这一点很重要，因为这个领域正在迅速变化，新的机会正在涌现 通常，由于所有资源都可用，这些准备开始的开发项目可能 当P50准备好开始时，将不再获得资金。 开发项目#1：B细胞恶性肿瘤的超声靶向基因传递 主要研究员：Dmitri Simberg，博士1 共同调查者：Robert F.Mattrey，M.D.2和Thomas J.Kipps，M.D.3，Ph.D. 科室：摩尔癌症中心(1)、放射科(2)和内科(3)

Development Projects and Funds Total Budget: $120,000/year. As stated earlier, the $120,000 proposed with this submission is not fixed. It may increase or decrease depending upon the needs, available funds, available projects in the portfolio and programmatic oversight. Development funds will be supported from the general pool as well as other funding opportunities through the Cancer Center and other internal and external funding sources. The three projects presented here were the three that ranked the highest by the Scientific Review Committee that reviewed eight 1-page abstracts for inclusion in this submission. Two of the three submitted last year were again chosen for inclusion. The committee felt that their scientific and clinical implications were not adequately presented. The third project submitted last year was recent funding by the DOD. It was replaced by a projected submitted by a rising start in stem cell neoplasia. As emphasized these three projects might not be the ones we will fund should the P50 be awarded. Upon release of funds, the Scientific Steering Committee will again solicit submissions and will review the portfolio of projects and select the most appropriate and highest ranked for funding that the Steering Committee will need to approve. This is important since the field is changing rapidly, new opportunities are coming on line frequently, and these Development Projects that are ready to begin since all the resources are available, may get funded and will no longer when the P50 is ready to begin. Development Project #1: Ultrasound Targeted Gene Delivery in B-Cell Malignancies Principal Investigator: Dmitri Simberg, Ph.D.1 Co-Investigators: Robert F. Mattrey, M.D.2 and Thomas J. Kipps, M.D.3, Ph.D. Departments: Moores Cancer Center (1) Radiology (2) and Internal Medicine (3)