Developmental Projects

发展项目

• 批准号: 7490292
• 负责人: ROBERT F MATTREY
• 金额: $ 12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490292
• 关键词: Antibodies; Award; B lymphoid malignancy; B-Cell Development; B-Lymphocytes; Binding; Biological; Blood; Blood specimen; Budgets; Cancer Center; Cell Line; Cell Wall; Cell membrane; Cells; Clinical; Commit; Complex; DNA; DNA Sequence; DNA delivery; Development; Doctor of Philosophy; Drug Formulations; Ensure; Frequencies; Funding; Funding Agency; Funding Opportunities; Gases; Gene Delivery; Genes; Goals; Green Fluorescent Proteins; In Vitro; Integral Membrane Protein; Internal Medicine; Label; Localized; Lymphoma; MS4A1 gene; Mediating; Microbubbles; Microscopy; Monoclonal Antibody CD20; Mus; Neoplasms; Nucleic Acids; One-Step dentin bonding system; Pharmaceutical Preparations; Principal Investigator; Radiology Specialty; Research Personnel; Resources; Review Committee; Small Interfering RNA; Staging; Stem cells; TNFRSF5 gene; TNFSF5 gene; Testing; Therapeutic Uses; Transfection; Ultrasonography; Water; abstracting; base; blood fractionation; cancer therapy; design; in vivo; neoplastic cell; plasmid DNA; rituximab; sonoporation; transgene expression; tumor

Development Projects and Funds Total Budget: $120,000/year. As stated earlier, the $120,000 proposed with this submission is not fixed. It may increase or decrease depending upon the needs, available funds, available projects in the portfolio and programmatic oversight. Development funds will be supported from the general pool as well as other funding opportunities through the Cancer Center and other internal and external funding sources. The three projects presented here were the three that ranked the highest by the Scientific Review Committee that reviewed eight 1-page abstracts for inclusion in this submission. Two of the three submitted last year were again chosen for inclusion. The committee felt that their scientific and clinical implications were not adequately presented. The third project submitted last year was recent funding by the DOD. It was replaced by a projected submitted by a rising start in stem cell neoplasia. As emphasized these three projects might not be the ones we will fund should the P50 be awarded. Upon release of funds, the Scientific Steering Committee will again solicit submissions and will review the portfolio of projects and select the most appropriate and highest ranked for funding that the Steering Committee will need to approve. This is important since the field is changing rapidly, new opportunities are coming on line frequently, and these Development Projects that are ready to begin since all the resources are available, may get funded and will no longer when the P50 is ready to begin. Development Project #1: Ultrasound Targeted Gene Delivery in B-Cell Malignancies Principal Investigator: Dmitri Simberg, Ph.D.1 Co-Investigators: Robert F. Mattrey, M.D.2 and Thomas J. Kipps, M.D.3, Ph.D. Departments: Moores Cancer Center (1) Radiology (2) and Internal Medicine (3)

发展项目和基金 总预算：120，000美元/年。 如前所述，本文件提议的120 000美元不是固定的。它可能会增加或减少 取决于需求、可用资金、组合中的可用项目和方案监督。 发展资金将由普通资金池以及通过 癌症中心和其他内部和外部资金来源。 这里介绍的三个项目是科学评论排名最高的三个项目 委员会审查了8份1页摘要以纳入本提交材料。三人中有两人提交了 去年再次入选。委员会认为，它们的科学和临床意义是 没有充分呈现。去年提交的第三个项目是国防部最近资助的。这是 取而代之的是干细胞肿瘤的上升趋势。 正如强调的那样，这三个项目可能不是我们将资助的P50项目。后 在资金释放后，科学指导委员会将再次征求意见，并将审查 项目，并选择指导委员会将需要的最适当和最高级别的资金 批准这一点很重要，因为该领域正在迅速变化，新的机会即将到来 这些发展项目由于所有资源都已到位，已准备好开始， 当P50准备好开始时，它将不再获得资金。 开发项目#1：B细胞恶性肿瘤中的超声靶向基因递送 主要研究者：Dmitri Simberg，Ph.D.1 合作研究者：Robert F. Mattrey，医学博士2和托马斯J. Kipps，医学博士3，博士 部门：Moores癌症中心（1）放射科（2）和内科（3）