Cancer Center Support Grant - Clinical Trials Reporting Supplement (CTRP)

描述(由申请人提供)：本申请要求续签韦恩州立大学底特律大都会迈耶·L·普伦蒂斯综合癌症中心(CCSG)24-28年的NCI癌症中心支持补助金(CCSG)。由卡马诺斯癌症研究所管理的癌症中心重新建立了强劲的研究增长轨迹，对其行政服务和组织进行了重大重组，新的领导层和同行审查资金的增加。癌症中心的项目反映了大都市底特律地区的癌症需求。这是一个工业化、城市和种族多元化的社区，有不成比例的医疗弱势群体，社会经济地位低下的公民。该癌症中心长期致力于研究和临床服务，致力于癌症的预防、早期发现和治疗，特别是非裔美国人和阿拉伯裔美国人，他们的乳腺癌、前列腺癌和航空消化系统癌症的死亡率不成比例。我们的拨款要求支持五个研究项目、十个核心设施、五个高级领导人、五个工作人员调查人员、发展基金和相关的行政支持。癌症中心已建立的研究项目包括乳腺癌、发育治疗学、分子生物学和人类遗传学、人口研究和预防以及蛋白水解酶和癌症。CCSG还要求为生物信息学、生物统计学、癌症中心信息学、临床试验办公室、细胞资源、基因组学、人体组织和病理学、共聚焦成像、流式细胞术和药理学的核心提供支持。我们的计划旨在将基础研究、转化研究和临床研究与以人口研究为基础的癌症控制活动相结合。癌症中心将继续促进学科内和学科间的互动和合作，并利用CCSG发展基金招募新的研究人员，并开发具有很高同行审查资金潜力的转化性研究项目。

DESCRIPTION (provided by applicant): This application requests renewal for years 24-28 of the NCI Cancer Center Support Grant (CCSG) for the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit at Wayne State University. The Cancer Center, which is managed by the Karmanos Cancer Institute, has re-established a strong trajectory of research growth with a significant re-organization of its administrative services and organization, new leadership and ant increase in peer-reviewed funding.The programs of the Cancer Center reflect the cancer needs of the greater Metropolitan Detroit area. This is an industrialized, urban and ethnically diverse community with a disproportionate number of medically disadvantaged, low socio-economic citizens. This Cancer Center has a long-standing and extensive commitment to both research and clinical services that address the prevention, earlier detection and treatment of cancer, particularly of African American and Arab American populations which experience disproportionate mortality from breast, prostate and aero-digestive cancers. Our grant requests support for five research programs, ten core facilities, five senior leaders, five staff investigators, developmental funds, and related administrative support. The Cancer Center's established research programs are Breast Cancer; Developmental Therapeutics; Molecular Biology and Human Genetics; Population Studies and Prevention, and Proteases and Cancer. CCSG support is also requested for Cores in Bioinformatics, Biostatistics, Cancer Center Informatics, Clinical Trials Office, Cell Resources, Genomics, Human Tissue and Pathology, Confocal Imaging, Flow Cytometry and Pharmacology. Our Programs are organized to integrate basic, translational, and clinical research with population research-based, cancer control activities. The Cancer Center will continue to foster intra- and inter-disciplinary interactions and collaborations, and to utilize CCSG developmental funds to recruit new investigators and to develop translational research programs that have a high potential for peer-reviewed funding.