Alzheimer's Disease Research Center at Columbia University

哥伦比亚大学阿尔茨海默病研究中心

• 批准号: 8141698
• 负责人: MICHAEL L SHELANSKI
• 金额: $ 6.72万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141698
• 关键词: Age; Alzheimer' s Disease; Autopsy; Award; Biological; Biology; Caring; Clinical; Clinical Research; Clinical Trials; Cognition Disorders; Cognitive; Communities; Consult; DNA; DNA Library; Data; Databases; Dementia; Developed Countries; Diagnosis; Disease; Education; Elderly; Enrollment; Environment; Ethics; Family; Gene Expression; Genetic; Genetic Variation; Genotype; Goals; Grant; Health Insurance Portability and Accountability Act; Hereditary Disease; Human; Imaging Device; Individual; Knowledge; Life; Lipids; Maintenance; Medical; Minority; Molecular and Cellular Biology; Mutation; Neurologic; Participant; Pathologic; Patients; Pharmaceutical Preparations; Physicians; Population; Prevention; Public Health; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scientist; Serum; Services; Staging; Time; Tissues; Universities; age related; brain tissue; disease natural history; improved; innovation; neuropsychological; operation; patient population; prevent; public health relevance; research study; symposium; therapy development; tool; user-friendly

DESCRIPTION (provided by applicant): The ADRC at Columbia seeks to advance and disseminate knowledge of the causes, prevention and treatment of Alzheimer's Disease and other age-related dementing disorders. To do this, we maintain and follow a multi-ethnic and multi-racial patient population of normal elderly and the elderly with cognitive disorders to establish the natural history of the disease as a function of age and of genetic makeup. In this application we propose to use a variety of neuropsychological, neurological and imaging tools to examine the earliest stages of AD and to follow these subjects throughout their lives and to compare them to other dementing diseases. A comprehensive neuropathologic examination will be performed on the deceased participants correlated with the clinical, radiological and genetic data. Tissues and DNA obtained from these subjects will be available for research on the biology and genetics of the disease. Individual research projects within the ADRC will examine various aspects of the cellular and molecular biology of AD with emphasis on lipids, on retromer function and on the relationship of GBA mutations to dementia. Patients enrolled in the ADRC will have the opportunity to participate in trials of new drugs and treatments for dementing diseases as they become available. The well-documented cognitive status of these patients makes them highly suitable for inclusion in clinical trials. The Education and Information Core of the Columbia ADRC endeavors to educate both lay and medical communities about AD, about the latest advances in research and about the care of the AD patient. The ADRC serves as a resource for scientists with Columbia as well as outside of it, encouraging new research avenues by the award of pilot grants, by providing tissues and other biological samples, by providing access to a carefully documented patient population and by numerous seminars and Clinical Pathological Correlation Conferences. The Genetics Core serves as the major organizer of family recruitment and identification across the ADRCs and ADCs as well as resources for genotyping and gene expression studies. HIPAA compliant data organization and statistical consulting services are provided under the ADRC to the research community at Columbia and external to it.

描述（由申请人提供）：在哥伦比亚的ADRC寻求推进和传播的原因，预防和治疗阿尔茨海默氏症和其他年龄相关的痴呆症的知识。为了做到这一点，我们保持和遵循一个多民族和多种族的正常老年人和老年人认知障碍的患者群体，以建立疾病的自然史作为年龄和遗传组成的函数。在本申请中，我们建议使用各种神经心理学，神经学和成像工具来检查AD的最早阶段，并在这些受试者的一生中跟踪这些受试者，并将其与其他痴呆疾病进行比较。将对死亡的受试者进行与临床、放射学和遗传数据相关的全面神经病理学检查。从这些受试者身上获得的组织和DNA将可用于研究该疾病的生物学和遗传学。ADRC内的个人研究项目将研究AD的细胞和分子生物学的各个方面，重点是脂质，retromer功能和GBA突变与痴呆症的关系。参加ADRC的患者将有机会参加痴呆症新药和治疗方法的试验。这些患者的认知状态得到充分证明，使其非常适合纳入临床试验。哥伦比亚ADRC的教育和信息核心致力于教育非专业和医学界关于AD，关于研究的最新进展和关于AD患者的护理。ADRC作为哥伦比亚内外科学家的资源，通过提供组织和其他生物样本，通过提供仔细记录的患者人群以及众多研讨会和临床病理学相关会议，鼓励新的研究途径。遗传学核心是ADRC和ADC家族招募和鉴定的主要组织者，也是基因分型和基因表达研究的资源。根据ADRC向哥伦比亚和外部的研究团体提供符合HIPAA的数据组织和统计咨询服务。