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中文摘要
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描述(申请人提供):正常衰老导致的认知功能丧失是众所周知的,虽然明显不同于阿尔茨海默病和其他与年龄相关的痴呆症中出现的灾难性记忆丧失,但越来越多的美国人对此感到担忧。这项申请寻求支持,以招募一名优秀的初级教员到哥伦比亚大学陶布研究所研究动物或人类大脑的正常衰老过程。 公共卫生相关性:如果我们要减缓老龄化人口的认知能力下降,了解大脑正常衰老的机制是至关重要的。这将使我们能够了解导致认知能力减退和痴呆症加速的因素。
英文摘要
DESCRIPTION (provided by applicant): The loss of cognitive function with normal aging is well known and while clearly different from the catastrophic loss of memory seen in Alzheimer's disease and the other age-related dementias, is of concern to an increasing number of Americans. This application seeks support to recruit an outstanding junior faculty member to the Taub Institute at Columbia University to study the normal aging process in either the animal or the human brain. PUBLIC HEALTH RELEVANCE: An understanding of the mechanisms of normal aging in the brain is critical if we are to slow cognitive decline in our aging population. It will enable us to understand the factors that lead to accelerated cognitive decline and dementia.
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Targeting Caspase-2 in Alzheimer's Disease
Targeting Caspase-2 in Alzheimer's Disease
Prospective Purification of Adult Stem Cell Astrocytes
Faculty recruitment on the Neurobiology of Aging