Infection and Stroke in Mexican Americans

墨西哥裔美国人的感染和中风

基本信息

批准号：
8121534
负责人：
Shawnita Sealy-Jefferson
金额：
$ 3.49万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8121534
关键词：
Accounting Activities of Daily Living Adult Age Aging Antibodies Antibody Formation Area Biology C-reactive protein Cause of Death Cessation of life Chronic Clinical Comorbidity Coronary heart disease Cytomegalovirus Data Data Collection Data Storage and Retrieval Diabetes Mellitus Educational workshop Epidemiologic Studies Epidemiologist Epidemiology Ethics Etiology Faculty Fellowship Gender Goals Grant Hand Helicobacter pylori Herpesvirus 1 Hispanic Americans Hypertension Immunoglobulin G Infection Infectious Agent Inflammation Inflammatory Interleukin-6 Investigation Knowledge Laboratories Laboratory Study Laboratory Technicians Latino Learning Link Measures Mediating Methods Mexican Mexican Americans Michigan Minority Neurologist Not Hispanic or Latino Outcome Outcome Measure Participant Pathway interactions Persons Population Research Research Personnel Review Literature Risk Risk Factors Schedule Science Series Smoking Socioeconomic Status Stroke Stroke prevention Students Sum Surveillance Methods TNF gene Techniques Training Tumor Necrosis Factor-alpha United States Universities Writing career disability experience follow-up functional disability functional outcomes health disparity inflammatory marker instrumental activity of daily living meetings pathogen population based post stroke programs quality assurance skills symposium

项目摘要

Stroke is the third leading cause of death and leading cause of disability in adults in the US. Nearly 800,000 people suffer a stroke annually, and more than 143,000 deaths occur as a result. Hispanic Americans are the fastest growing minority population in the US, as well as the most numerous. The majority of Hispanic Americans are of Mexican descent. Mexican Americans (MAs) have an increased risk of stroke especially at younger ages when disability has the greatest impact. Reasons for increased stroke risk in MAs are not fully understood but traditional risk factors are not likely to fully account for the increased stroke burden in this population. Chronic infectious pathogens have been proposed as risk factors for stroke and for poor stroke outcome, although the evidence remains inconclusive and studies have not been done in MAs. As chronic infections are more prevalent in MAs than their non-Hispanic white counterparts, this risk factor may be particularly important for this population. The proposed dissertation research seeks to examine the links between chronic infection and incident stroke and post-stroke functional outcome, among participants from the Sacramento Area Latino Study on Aging (SALSA). This research will extend current knowledge of infection and stroke in several critical ways:1) by examining antibody response to several infectious agents versus infection serostatus as independent risk factors for stroke, 2) by examining the underlying mechanisms, including inflammatory pathways, by which antibody response may influence stroke risk, 3) by investigating the association of antibody response to post-stroke functional outcomes and 4) by focusing specifically in a MA population known to experience a greater stroke burden as well as a greater infection burden. The recognition that infection increases stroke risk after accounting for traditional risk factors may have important implications for the prevention of stroke in MAs and for reducing the stroke health disparity in this population. In addition to advancing the science in this critical area, the proposed fellowship will provide the rigorous training, including coursework and seminars/workshops, interaction with stroke neurologists and epidemiologists and hands-on training in population-based studies and laboratory methods, needed to develop the applicant from a doctoral student to an independent investigator who will devote her research career to the study of stroke and its determinants, including infection.

中风是美国成年人的第三大死亡原因和残疾的主要原因。每年有近80万人遭受中风，因此发生了143,000多人死亡。西班牙裔美国人是美国增长最快的少数族裔，也是最多数。大多数西班牙裔美国人都是墨西哥血统。墨西哥裔美国人（MAS）的中风风险增加了，尤其是在残疾影响最大的年轻年龄。 MAS中风风险增加的原因尚未完全理解，但是传统的风险因素不太可能完全解释该人群中的中风负担增加。尽管证据仍然尚无定论，但在MAS中尚未进行研究，但已提出了慢性传染病病原体作为中风和中风结果不良的危险因素。由于在MAS中，慢性感染比非西班牙裔白人对应物更为普遍，因此这种危险因素对该人群尤为重要。拟议的论文研究旨在研究萨克拉曼多地区拉丁裔衰老研究（SALSA）的参与者（SALSA）的参与者中的慢性感染与中风后功能结果之间的联系。这项研究将以几种关键的方式扩展当前对感染和中风的知识：1）通过检查对几种感染因素与感染的抗体反应作为中风的独立风险因素，2）通过检查炎症途径，包括抗体响应，通过研究抗体响应的炎症途径，通过研究抗体响应，通过研究抗体响应的群体响应，并通过对抗体响应进行抗体响应，3）抗体响应，3）较大的中风负担以及更大的感染负担。在考虑传统危险因素后，认识到感染会增加中风风险，这可能对预防MAS中的中风和减少该人群的中风健康差异具有重要意义。除了推进这一关键领域的科学外，拟议的奖学金还将提供严格的培训，包括课程和研讨会/研讨会，与中风神经科医生和流行病学家的互动以及基于人群的研究和实验室方法所需的动手培训，以从博士生中开发申请人，从博士生到独立研究者将其研究职业投入研究生涯，包括研究自己的研究及其研究及其库克的含义，并包括其确定性的inftiment ofst of Stroke及其确定性的研究。