Infection and Stroke in Mexican Americans

墨西哥裔美国人的感染和中风

• 批准号: 8306286
• 负责人: Shawnita Sealy-Jefferson
• 金额: $ 0.53万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-10-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8306286
• 关键词: Accounting; Activities of Daily Living; Adult; Age; Aging; Antibodies; Antibody Formation; Area; Biology; C-reactive protein; Cause of Death; Cessation of life; Chronic; Clinical; Comorbidity; Coronary heart disease; Cytomegalovirus; Data; Data Collection; Data Storage and Retrieval; Diabetes Mellitus; Educational workshop; Epidemiologic Studies; Epidemiologist; Epidemiology; Ethics; Etiology; Faculty; Fellowship; Gender; Goals; Grant; Hand; Helicobacter pylori; Herpesvirus 1; Hispanic Americans; Hypertension; Immunoglobulin G; Infection; Infectious Agent; Inflammation; Inflammatory; Interleukin-6; Investigation; Knowledge; Laboratories; Laboratory Study; Laboratory Technicians; Latino; Learning; Link; Measures; Mediating; Methods; Mexican; Mexican Americans; Michigan; Minority; Neurologist; Not Hispanic or Latino; Outcome; Outcome Measure; Participant; Pathway interactions; Persons; Population; Research; Research Personnel; Review Literature; Risk; Risk Factors; Schedule; Science; Series; Smoking; Socioeconomic Status; Stroke; Stroke prevention; Sum; Surveillance Methods; TNF gene; Techniques; Training; Tumor Necrosis Factor-alpha; United States; Universities; Writing; career; disability; doctoral student; experience; follow-up; functional disability; functional outcomes; health disparity; inflammatory marker; instrumental activity of daily living; meetings; pathogen; population based; post stroke; programs; quality assurance; skills; symposium

Stroke is the third leading cause of death and leading cause of disability in adults in the US. Nearly 800,000 people suffer a stroke annually, and more than 143,000 deaths occur as a result. Hispanic Americans are the fastest growing minority population in the US, as well as the most numerous. The majority of Hispanic Americans are of Mexican descent. Mexican Americans (MAs) have an increased risk of stroke especially at younger ages when disability has the greatest impact. Reasons for increased stroke risk in MAs are not fully understood but traditional risk factors are not likely to fully account for the increased stroke burden in this population. Chronic infectious pathogens have been proposed as risk factors for stroke and for poor stroke outcome, although the evidence remains inconclusive and studies have not been done in MAs. As chronic infections are more prevalent in MAs than their non-Hispanic white counterparts, this risk factor may be particularly important for this population. The proposed dissertation research seeks to examine the links between chronic infection and incident stroke and post-stroke functional outcome, among participants from the Sacramento Area Latino Study on Aging (SALSA). This research will extend current knowledge of infection and stroke in several critical ways:1) by examining antibody response to several infectious agents versus infection serostatus as independent risk factors for stroke, 2) by examining the underlying mechanisms, including inflammatory pathways, by which antibody response may influence stroke risk, 3) by investigating the association of antibody response to post-stroke functional outcomes and 4) by focusing specifically in a MA population known to experience a greater stroke burden as well as a greater infection burden. The recognition that infection increases stroke risk after accounting for traditional risk factors may have important implications for the prevention of stroke in MAs and for reducing the stroke health disparity in this population. In addition to advancing the science in this critical area, the proposed fellowship will provide the rigorous training, including coursework and seminars/workshops, interaction with stroke neurologists and epidemiologists and hands-on training in population-based studies and laboratory methods, needed to develop the applicant from a doctoral student to an independent investigator who will devote her research career to the study of stroke and its determinants, including infection.

中风是美国成年人的第三大死亡原因和导致残疾的主要原因。每年有近 80 万人遭受中风，超过 143,000 人因此死亡。拉美裔美国人是美国增长最快、数量最多的少数族裔。大多数西班牙裔美国人是墨西哥裔。墨西哥裔美国人 (MA) 中风的风险增加，尤其是在年轻时，残疾的影响最大。 MA 中风风险增加的原因尚不完全清楚，但传统的危险因素不太可能完全解释该人群中风负担的增加。慢性传染性病原体已被认为是中风和中风不良结局的危险因素，尽管证据仍不确定，并且尚未在 MA 中进行研究。由于慢性感染在马萨诸塞州比非西班牙裔白人更普遍，因此这一危险因素对于这一人群可能特别重要。拟议的论文研究旨在研究萨克拉门托地区拉丁裔老龄化研究 (SALSA) 参与者中慢性感染与中风和中风后功能结果之间的联系。这项研究将以几种关键方式扩展当前对感染和中风的认识：1）通过检查对几种感染原的抗体反应与感染血清状态作为中风的独立危险因素，2）通过检查潜在的机制，包括炎症途径，抗体反应可能影响中风风险，3）通过调查抗体反应与中风后功能结果的关联，4）通过特别关注已知经历过 MA 的人群 更大的中风负担以及更大的感染负担。在考虑了传统危险因素后，认识到感染会增加中风风险，这可能对预防 MA 中风和减少该人群中风健康差异具有重要意义。除了推进这一关键领域的科学发展外，拟议的奖学金还将提供严格的培训，包括课程和研讨会/讲习班、与中风神经学家和流行病学家的互动以及基于人群的研究和实验室方法的实践培训，这些都是将申请人从博士生培养为独立研究者所需的，她将把她的研究生涯致力于中风及其决定因素（包括感染）的研究。