Integrative Lipid Metabolism, Inflammation, and Chronic Diseases

描述(由申请人提供)： 这项申请是为了一项新的T32拨款，重点是在脂类科学、炎症和慢性病领域对博士生预科学生进行培训。脂代谢和炎症的紊乱是许多慢性疾病(包括动脉粥样硬化、系统性红斑狼疮、哮喘和癌症)发病机制的核心，但很少有集成的博士前培训课程专注于慢性疾病发病机制和治疗中的脂类科学。该培训计划有12名具有跨学科背景和专业知识的导师，他们主要在五个系担任学术职务-病理学、内科(胃肠病和风湿病学)、放射科学、生理学/药理学和癌症生物学。正在申请资金支持四名博士前实习生的培训，他们将在维克森林大学文理研究生院的四个研究生项目(分子和细胞病理学、分子医学、生物化学和分子遗传学)中的一个项目中获得博士学位。这一培训计划是成熟的投资者们自然地持续合作的结果，他们聚集在维克森林大学医学院市中心校区一栋最先进的研究大楼的一层楼里。导师们对脂代谢在慢性疾病发病机制中的作用有共同的研究兴趣，慢性疾病仍然是美国公民死亡和发病的主要原因之一。所有导师目前至少与一名其他导师合作，并且是NIH拨款的主要调查人员和/或计划、项目或中心拨款的项目负责人。培训将涉及一种综合的、多学科的方法，使用分子、细胞和整个动物实验。对学生的培训将包括严格的教学课程、研讨会、期刊俱乐部、计划项目会议、植物中心会议、伦理和专业发展培训、参与尖端研究项目、拨款撰写以及在地区和国家会议上的科学陈述。我们的受训学生将被要求在T32的初步支持后编写F31应用程序。学生的重点领域将包括：1)脂代谢的功能基因组学，2)脂沉积的活体成像，3)植物脂类在慢性疾病治疗中的作用，4)脂类的大分子组装，5)脂类运输生物学，以及6)在慢性病的发病机制和治疗中的生物活性脂类。每个领域至少有两名教职员工，他们将以共同指导的关系参与研究生的培训和监督。还有一条为注册分子医学研究生课程的学生提供的翻译研究轨道。完成我们培训计划的研究生将拥有知识、技能和培训，加入到学术界、政府或行业的国家努力中，以减少美国公民因脂类代谢障碍和炎症引起的慢性疾病的痛苦和死亡。

DESCRIPTION (provided by applicant): This application is for a new T32 grant to focus training of pre-doctoral students in the areas of lipid science, inflammation, and chronic diseases. Disturbances in lipid metabolism and inflammation are central to the pathogenesis of many chronic diseases (including atherosclerosis, systemic lupus erythematosus, asthma, and cancer) but few integrated predoctoral training programs focus on lipid sciences in the pathogenesis and treatment of chronic diseases. This training program has 12 mentors, with interdisciplinary backgrounds and expertise, who have primary academic appointments in five departments - Pathology, Internal Medicine (Sections on Gastroenterology and Rheumatology), Radiologic Sciences, Physiology/Pharmacology, and Cancer Biology. Funds are being requested to support the training of four predoctoral trainees who are earn- ing the PhD degree in one of four graduate programs (Molecular and Cellular Pathobiology, Molecular Medi- cine, Biochemistry, and Molecular Genetics) of the Graduate School of Arts and Sciences at Wake Forest University. This training program has resulted from the natural on-going collaboration of established investi- gators who have been assembled onto one floor of a state-of-the-art research building on the downtown campus of the Wake Forest University School of Medicine. Mentors have a common research interest in the role of lipid metabolism in the pathogenesis of chronic diseases that continue to be among the leading causes of death and morbidity of US citizens. All mentors are currently collaborating with at least one other mentor and are principal investigators on NIH grants and/or project leaders on Program Project or Center grants. Training will involve an integrated, multidisciplinary approach that uses molecular, cellular, and whole animal experimentation. Training for students will include rigorous didactic courses, seminars, journal clubs, Program Project meetings, Botanical Center meetings, ethics and professional development training, partici- pation in cutting-edge research projects, grant writing, and scientific presentations at regional and national meetings. Our trainees will be required to write a F31 application after initial support on the T32.Specific areas of focus for students will include: 1) Functional genomics of lipid metabolism, 2) In vivo imaging of lipid deposition, 3) Botanical lipids in the treatment of chronic diseases, 4) Macromolecular assembly of lipids, 5) Lipid transport biology, and 6) Bioactive lipids in the pathogenesis and treatment of chronic diseases. Each area contains at least two faculty members who will participate in the training and supervision of graduate students in a co-mentoring relationship. There is also a translational research track for students who enroll in the Molecular Medicine graduate program. Graduate students completing our training program will have the knowledge, skills, and training to join the national effort in academia, government, or industry to reduce the suffering and death of US citizens from chronic diseases that result from disturbances in lipid metabolism and inflammation.