Inflammation and hepatic lipid metabolism

炎症与肝脏脂质代谢

基本信息

  • 批准号:
    10453674
  • 负责人:
  • 金额:
    $ 52.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Abstract There is little doubt that we are in the midst of a worldwide epidemic of obesity and diabetes. Among the many complications of obesity is fatty liver, and its associated disease Nonalcoholic Steatotic Hepatitis (NASH). However, the manner by which lipid storage and oxidation is controlled in liver is only partly understood. We hypothesize that inflammation plays a role in this process through the protein kinase TBK1. TBK1 associates with the key enzyme ACSL1, localizing it to mitochondria for fatty acid oxidation during starvation, and to ER for fatty acid re-esterification during obesity. Moreover, TBK1 represses the activity of AMPK during obesity, linking fatty liver to liver damage. We will explore the nature of these pathways with three aims: 1) We will elucidate the temporal and spatial aspects of the induction and activation of the kinase TBK1 in fasting and obesity; 2) We will deeply explore the molecular mechanism involved in its interaction with ACSL1; and 3) We will evaluate the molecular mechanisms whereby TBK1 reduces the activity of AMPK, and how this results in hepatocellular death and liver damage.
摘要

项目成果

期刊论文数量(0)
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ALAN R. SALTIEL其他文献

ALAN R. SALTIEL的其他文献

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{{ truncateString('ALAN R. SALTIEL', 18)}}的其他基金

Hormonal regulation of LDL receptor trafficking
LDL 受体运输的激素调节
  • 批准号:
    10491294
  • 财政年份:
    2021
  • 资助金额:
    $ 52.54万
  • 项目类别:
Hormonal regulation of LDL receptor trafficking
LDL 受体运输的激素调节
  • 批准号:
    10365256
  • 财政年份:
    2021
  • 资助金额:
    $ 52.54万
  • 项目类别:
Inflammation and hepatic lipid metabolism
炎症与肝脏脂质代谢
  • 批准号:
    10187564
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Adipose tissue plasticity in health and disease
健康和疾病中的脂肪组织可塑性
  • 批准号:
    10201590
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Adipose tissue plasticity in health and disease
健康和疾病中的脂肪组织可塑性
  • 批准号:
    10617185
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Regulating energy expenditure in adipose tissue
调节脂肪组织的能量消耗
  • 批准号:
    10121033
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Regulating energy expenditure in adipose tissue
调节脂肪组织的能量消耗
  • 批准号:
    10434151
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Inflammation and hepatic lipid metabolism
炎症与肝脏脂质代谢
  • 批准号:
    10033511
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Inflammation and hepatic lipid metabolism
炎症与肝脏脂质代谢
  • 批准号:
    10649651
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:
Adipose tissue plasticity in health and disease
健康和疾病中的脂肪组织可塑性
  • 批准号:
    10394928
  • 财政年份:
    2020
  • 资助金额:
    $ 52.54万
  • 项目类别:

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