Research Training in Muscle Biology of Cardiopulmonary Disease

描述（由申请人提供）： 心肺疾病的进展和治疗干预的有效性严重依赖于心血管和肺系统中的心肌、平滑肌和骨骼肌的反应。所有这三种肌肉类型对于正常的心肺功能都是必不可少的，所有这三种肌肉类型在心血管和肺部疾病中都起着关键作用，并且都是治疗开发的目标。目前的计划针对生物医学的这一领域，通过培训博士前和医学生在心肺疾病的背景下进行肌肉研究。肯塔基州（英国）的大学非常适合该计划。英国是一所公立研究机构，拥有33，692名本科生和研究生，1，920名教职员工，2006年的校外研究支持为2.9亿美元，以及由六所不同的健康相关学院组成的医学中心。最近通过的一项战略计划要求通过增加教师，扩大研究生课程和新的研究设施来快速增长英国研究。在这个充满活力的学术环境中，英国心脏病肌肉生物学研究培训计划将建立在机构优势的基础上，培养优秀的学生从事基础和转化研究。在一个高度选择性的审查过程中，计划领导将确定并招募最合格的申请人参加两个精英计划。来自八个不同的博士课程的研究生将在博士后奖学金计划中竞争两年的全职任命。一个类似的竞争将确定研究型医学生为期八周的夏季学者计划。这两组学者将由来自10个基础科学和临床部门的22名教师指导。多学科指导团队将在心脏，血管平滑肌和呼吸骨骼肌生物学的相关领域培训学者。个性化课程将结合联合收割机课程作业，实验室培训和结构化的临床经验，以实现三个具体目标：1。准备在预科水平的基础科学家在心肺研究成功的长期职业生涯; 2。让博士前医学生参加暑期实验室体验，激发对基础和转化研究的持续兴趣; 3）培养优秀的项目教师和博士前学者的指导技能。

DESCRIPTION (provided by applicant): The progression of cardiopulmonary disease and the efficacy of therapeutic interventions are critically dependent on the response of cardiac, smooth, and skeletal muscles in the cardiovascular and pulmonary systems. All three muscle types are essential for normal cardiopulmonary function, all three play key roles in cardiovascular and pulmonary disease, and all are targets for therapeutic development. The current program targets this area of biomedicine by training predoctoral and medical students for muscle research in the context of cardiopulmonary disease. The University of Kentucky (UK) is ideally suited for the program. UK is a public research institution with 33,692 undergraduate and graduate students, 1,920 faculty members, extramural research support of $290 million in 2006, and a medical center comprising six different health- related Colleges. A recently-adopted strategic plan calls for rapid growth of UK research via added faculty, expanded graduate programs, and new research facilities. Within this dynamic academic environment, the UK program for Research Training in Muscle Biology of Cardiopulmonary Disease will builds on institutional strengths to train exceptional students for careers in basic and translational research. In a highly-selective vetting process, program leadership will identify and recruit the best-qualified applicants for participation in two elite programs. Graduate students from eight different PhD programs will compete for two-year, full-time appointments in the Postdoctoral Scholar program. A similar competition will identify research-oriented medical students for an eight-week Summer Scholar program. Both groups of Scholars will be mentored by twenty-two faculty members from ten basic science and clinical departments. Multidisciplinary mentoring teams will train Scholars in relevant areas of cardiac, vascular smooth, and respiratory skeletal muscle biology. Individualized curricula will combine coursework, laboratory training, and a structured clinical experience to achieve three specific aims: 1.) To prepare basic scientists at the predoctoral level for successful long-term careers in cardiopulmonary research; 2.) To engage predoctoral medical students in a summer laboratory experience that stimulates ongoing interest in basic and translational research; and 3.) To foster excellence in the mentoring skills of both program faculty and predoctoral scholars.