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Using Arabidopsis to uncover interactions between phytohormone signaling pathways

利用拟南芥揭示植物激素信号通路之间的相互作用

基本信息

批准号：
8013311
负责人：
Lucia Strader
金额：
$ 8.98万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-15 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8013311
关键词：
Abscisic Acid Affinity Chromatography Agriculture Arabidopsis Area Auxins Binding Biochemical Biochemical Genetics Blood Vessels Cell division Characteristics Complement Development Dissection Embryonic Development Environment Ethylenes Excision Exhibits Fruit Genes Genetic Research Genetic Transcription Germination Goals Growth Growth and Development function Hormones Knowledge Learning Lesion MAPK Signaling Pathway Pathway Mentors Mitogen-Activated Protein Kinases Molecular Molecular Genetics Mouse-ear Cress Mutation Nature Pathway interactions Perception Phenotype Phosphoric Monoester Hydrolases Plant Growth Regulators Plant Leaves Plant Model Plant Roots Plants Postdoctoral Fellow Principal Investigator Protein Biosynthesis Protein phosphatase Proteins Regulation Reporter Repressor Proteins Research Resistance Resources Rice Role Saline Seeds Signal Pathway Signal Transduction Site Soil Specificity Stress Students Testing Time Training Universities base biological adaptation to stress career indoleacetic acid insight mutant novel positional cloning public health relevance research study response senescence stress tolerance tool

项目摘要

DESCRIPTION (provided by applicant): Candidate: The candidate's long-term career goal is to become a principal investigator in an academic setting, studying the interaction networks involved in phytohormone response. During the training period, she will learn biochemical research approaches to complement her graduate applied agricultural and post- doctoral molecular genetic research. Training Environment: Rice University provides an ideal training environment because of its quality research and intimate setting. Dr. Bonnie Bartel, the mentor for this project, is a leader in Arabidopsis research. Further, she is an active mentor who devotes the majority of her time to her research and her postdocs and students. Research: The long-term goal of this project is to enhance understanding of the signaling network that connects the phytohormones auxin, abscisic acid (ABA), and ethylene. The dual-specificity protein phosphatase, IBR5, the subject of this proposal, is a novel point of interaction between auxin, ABA, and ethylene signal transduction networks. Several interconnected approaches will use IBR5 to gain greater understanding of the relationship among these phytohormones. Firstly, IBR5-interacting proteins will be identified (Aim 1); these may include substrates and regulators of the IBR5 phosphatase. Additionally, second-site ibr5 modifiers will be analyzed (Aim 2) to determine whether sensitivity to auxin, ABA, and ethylene can be separated, or if they are interconnected in inseparable ways. Identification of defective genes in these modifiers (Aim 3) will allow molecular elucidation of interactions between these phytohormone pathways. These studies will contribute to understanding of which signaling components are shared among these three pathways and which are not shared, and will identify additional nodes in the phytohormone signaling network. In addition to expanding our basic knowledge, a detailed understanding of these three phytohormones, involved in growth responses, stress tolerance, and fruit ripening, may provide insight for the eventual improvement of plants of agricultural or medicinal importance. For instance, determining how to increase stress tolerance (ABA perception) without altering growth characteristics (auxin perception) or ripening (ethylene perception) could be key to adapting plants to high stress areas (i.e., areas of low rainfall or saline soils). Public Health Relevance: Auxin, abscisic acid, and ethylene are three plant hormones controlling many aspects of growth and development, such as growth responses, stress tolerance, and fruit ripening. Understanding of the signaling interactions between theses phytohormones, in addition to contributing to the general knowledge of how these hormones act, may provide insight for the eventual improvement of agriculturally- and medicinally-important plants. For instance, determining how to increase stress tolerance (ABA perception) without altering growth characteristics (auxin perception) or ripening (ethylene perception) could be key to adapting crops to high stress areas (i.e., areas of low rainfall or saline soils).

描述（由申请人提供）：