Clinical Research in Eating Disorders and Obesity

描述（由申请人提供）：饮食失调和肥胖的公共卫生意义是有据可查的，然而这些问题已知难以治疗。本申请是NIMH面向患者研究（K24）职业中期研究者奖的竞争性更新申请，以减轻Wilfley博士的临床，行政和教学职责，以确保保护时间：1)根据基础行为和生物医学科学的进步，继续开发和改进有效的治疗饮食和体重失调的方法；2)应用科学的实施方法，在社区部署以证据为基础的饮食和体重失调治疗；3)注重饮食和体重失调的预防和早期干预，防止合并症、复发和致残；4)参与教学和培训活动，帮助培养饮食失调和肥胖领域的下一代临床研究人员。在目前的奖励期间，Wilfley博士已经成功地完成了三个NIH资助的r01，启动了两个NIH资助的奖项，并且还有两个NIH临床研究试验正在进行中。她的研究已经确定了有效的干预措施，用于治疗暴饮暴食症和儿童肥胖的高风险妇女群体。同时，在此期间，她发表了超过45篇同行评审的手稿，并指导了17名博士生和博士后，以及初级教师。选定的正在进行和未决的奖项包括旨在测试对患有神经性厌食症的青少年进行早期干预的研究，对患有饮食失调的高风险妇女的强化预防方法，以及长期保持儿童体重减轻的方法。该申请描述了Wilfley博士的职业发展目标，以提高她在转化研究领域的专业知识，特别是弥合从治疗设计和改进到社区治疗实施和部署的差距。她计划加强她对神经影像学和精神遗传学的理解，以促进诊断、预防和治疗饮食和体重相关疾病的新策略的发展，并增加她的指导资源。相关性（见说明）：鉴于饮食失调和肥胖相关的高发病率和死亡率，需要不断改进治疗方法，并注重早期干预和预防。确保有效的治疗方法传播到社区，并惠及目标患者，这是当务之急。

DESCRIPTION (provided by applicant): The public health significance of eating disorders and obesity are well-documented, yet these problems are known to be resistant to treatment. This application is a request for a competitive renewal of an NIMH Midcareer Investigator Award in Patient Oriented Research (K24) in order to relieve Dr. Wilfley from clinical, administrative, and teaching duties, to ensure protected time to: 1) Continue developing and improving efficacious treatments for eating and weight disorders that are informed by advancements in the basic behavioral and biomedical sciences; 2) Apply scientific implementation methodology to the deployment of evidence-based treatments for eating and weight disorders into the community; 3) Focus on the prevention and early intervention of eating and weight disorders to prevent comorbidity, relapse, and disability; and 4) Engage in teaching and training activities that will help produce the next generation of clinical researchers in the area of eating disorders and obesity. During the present award period, Dr. Wilfley has successfully concluded three NIH-funded R01s, launched two NIH-sponsored awards, and has two more NIH clinical research trials pending. Her studies have identified effective interventions for a subset of women at high risk for developing eating disorders, for the treatment of binge eating disorder, and for childhood obesity. Also, during this time, she has published over 45 peer-reviewed manuscripts, and mentored 17 pre- and post- doctoral students, and junior faculty. Selected ongoing and pending awards include studies designed to test early interventions for adolescents with anorexia nervosa, an enhanced prevention approach for women at very high risk for developing eating disorders, and methods for maintaining weight loss in children over the long-term. This application describes career development goals for Dr. Wilfley to enhance her expertise in the areas of translational research, specifically to bridge the gap from treatment design and refinement to the implementation and deployment of treatments in the community. She plans to enhance her understanding of neuroimaging and psychiatric genetics to facilitate the development of novel strategies for diagnosis, prevention, and treatment of eating and weight related disorders and to augment her mentoring resources. RELEVANCE (See instructions): Given the high morbidity and mortality associated with eating disorders and obesity, a continued refinement of treatment approaches and focus on early intervention and prevention is required. Ensuring that effective treatments are disseminated to the community and reach the patients for whom they are intended is imperative.