WUSTL Transdisciplinary Pre- and Postdoctoral Training Program in Obesity and Cardiovascular Disease

项目总结/摘要 肥胖和心血管疾病的生物、行为、社会和环境危险因素的复杂性 疾病（CVD）需要团队科学，能够跨越特定学科的界限， 从跨学科的方法进行和评估研究，以预防和治疗肥胖和心血管疾病， 寿命努力促进在多个领域和不同级别接受过培训的科学家之间加强合作， 培训对于解决此类复杂问题不仅有价值，而且至关重要。因此，我们建议继续 在华盛顿的一个创新的，跨学科的肥胖和心血管疾病的博士前和博士后培训计划 圣路易斯大学（WUSTL）。WUSTL是一个促进跨学科的优秀研究机构， 翻译研究通过其独特的，合议，跨校园和部门的科学环境。 该计划：1）招募和培养具有跨学科能力的博士前和博士后培训生; 2）提供培训生 与合作，跨学科的导师团队; 3）目标在未来的科学劳动力的多样性;和 4)提供有关肥胖/心血管疾病研究的道德和社会责任行为的培训。国际 肥胖权威，丹尼斯威尔弗莱博士（主任）和塞缪尔克莱因，医学博士（联合主任），领导该计划， 由高素质的支持，主要和共同导师跨越12个部门在生物医学，认知和 行为和人口健康科学。我们的导师资金充足，并有强大的合作关系， 每年为4名博士前和4名博士后培训人员提供便利。结合博士前和博士后学员 从不同的背景（例如，遗传学，分子细胞生物学，心理学，社会工作，公共卫生， 神经科学）已经创造并将继续创造一个独特的动态培训环境。WUSTL 营养肥胖研究中心，临床和转化科学研究所，公共卫生研究所， 和糖尿病翻译研究中心提供基础设施和最先进的资源， 学员参与变革性的转化科学。受训人员完成的方案评估， 项目管理和协作指导团队确保学员实现短期和长期 生产力指标，使他们能够成功地获得学术职位和独立赠款。 事实上，该计划的博士后毕业生在获得学术职位方面非常成功 和赠款资金，并在我们的博士前学员的情况下，继续在著名的研究培训 岗位多元化咨询委员会告知我们在招聘和留住高素质人才方面的方法。 来自不同背景的合格学员。我们的培训计划不仅在设计上具有创新性， 使用由明星导师指导的团队科学方法，我们的学员准备创造和 有助于跨学科的科学方法，更有可能产生创新的解决方案， 肥胖和心血管疾病的复杂问题比以前由个别科学家在一个 单一学科领域。

PROJECT SUMMARY/ABSTRACT The complexities of biological, behavioral, social, and environmental risk factors for obesity and cardiovascular disease (CVD) necessitate team science, capable of crossing the boundaries of disciplinary-specific silos to conduct and evaluate research from a transdisciplinary approach to prevent and treat obesity and CVD across the lifespan. Efforts to facilitate greater collaboration among scientists trained across many fields and levels of training are not only valuable but also essential to solving such complex problems. Thus, we propose to continue an innovative, transdisciplinary pre- and postdoctoral training program in obesity and CVD at Washington University in St. Louis (WUSTL). WUSTL is an excellent research institution promoting transdisciplinary, translational research through its unique, collegial, scientific environment across campuses and departments. This program: 1) recruits and trains talented transdisciplinary pre- and postdoctoral trainees; 2) provides trainees with collaborative, transdisciplinary mentorship teams; 3) targets diversity in the future scientific workforce; and 4) provides training in the ethical and socially responsible conduct of obesity/CVD research. International authorities on obesity, Denise Wilfley, PhD (Director) and Samuel Klein, MD (Co-Director), lead the program, supported by highly- qualified, primary and co-mentors spanning 12 departments in the biomedical, cognitive and behavioral, and population health sciences. Our mentors are well-funded and have strong collaborative ties to facilitate the training of 4 pre- and 4 postdoctoral trainees each year. Combining pre- and postdoctoral trainees from diverse backgrounds (e.g., genetics, molecular cell biology, psychology, social work, public heath, and neurosciences) has created and will continue to create a uniquely dynamic training environment. The WUSTL Nutrition Obesity Research Center, Institute of Clinical and Translational Sciences, Institute for Public Health, and Center for Diabetes Translation Research provide infrastructure and state-of-the-art resources to support trainees' engagement in transformative, translational science. Program evaluations completed by trainees, program administration, and collaborative mentorship teams ensure trainees achieve short- and long-term indicators of productivity positioning them for success in obtaining academic positions and independent grants. Indeed, postdoctoral graduates of the program have been highly successful in obtaining academic positions and grant funding, and in the case of our predoctoral trainees, continuing their research training in prestigious positions. The Diversity Advisory Committee informs our approach in the recruitment and retention of highly qualified trainees from diverse backgrounds. Not only is our training program innovative in its design, but using a team science approach guided by stellar mentors, our trainees are prepared to create and contribute to transdisciplinary scientific approaches that are more likely to yield innovative solutions to the complex problems of obesity and CVD than research previously conducted by individual scientists within a single disciplinary field.