MT VET COBRE II CORE C: ANIMAL MODELS

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心赠款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 动物模型核心（核心C）由大卫帕斯夸尔博士指导，并提供资源和专业知识，以满足COBRE II初级研究者和与中心相关的其他研究者的需求，这些研究者建议在其研究中使用动物模型和/或在实施新动物模型方面需要专业知识和建议，以增强/扩展其研究计划。核心C旨在（a）为项目负责人和其他利用传染病发病机制动物模型的中心研究者提供技术、方法和分析支持，（B）提供资源和专业知识，以协助中心研究者利用和/或开发新的动物模型，以增强或扩展其研究计划，和（c）协助中心研究者访问BSL-3和ABSL-2动物研究机构，并协助方案准备，确保在使用任何动物之前将批准文件存档。 眼镜蛇II 本报告年度是COBRE II的第二个完整年度，其中核心C取代了最初COBRE I的一部分BSL-3核心（核心D）。核心C的开发和扩展是在2008年秋季审查期间与EAC进行广泛讨论的结果。根据EAC成员和COBRE II项目负责人的意见，概念化并创建了动物模型核心。核心C继续在COBRE I期间完成和开始的早期工作的基础上取得进展并从中受益。从这个时代开始，建立了BSL-3核心，以开发中心研究人员在人畜共患病研究中进行BSL-3生物研究所需的必要资源和设施。该中心在COBRE I期间完成了最先进的BSL-3设施的建设。该设施的完成和CDC认证使我们能够直接进入布鲁氏菌和柯克斯体发病机制的BSL-3方面项目，这些项目由NIH落基山生物防御卓越研究中心资助。此外，该设施的可用性使我们能够成功地竞争国家补充和替代医学中心的NIH计划项目，这是一项为期五年的天然产品对减少传染病和自身免疫性疾病的影响研究。在以下各节中，次级项目进度报告记录了核心C如何继续在过去成功的基础上再接再厉，并从其重组中受益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, and assist in protocol preparation and insure approvals are on file prior to any animal use. COBRE II This reporting year marks the second full year of COBRE II, where Core C replaced and transitioned from the BSL-3 Core (Core D), which was part of the initial COBRE I. The development and expansion of Core C was the result of extensive discussion with the EAC during the Fall 2008 review. Based on input from the EAC members and the COBRE II Project Leaders, the Animal Models Core was conceptualized and created. Core C continues to make strides on and benefits from the earlier work completed and started during COBRE I. From this era, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five-year study of natural products' impact on reducing infectious and autoimmune diseases. In the following sections, the subproject progress report documents how Core C continued to build on past successes and benefitted from its reorganization.