MT VET COBRE II CORE C: ANIMAL MODELS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 动物模型核心(核心C)由David Pascual博士指导，提供资源和专业知识，以满足Cobre II初级调查人员和与中心相关的其他调查人员的需求，这些调查人员建议在他们的研究中利用动物模型和/或在实施新的动物模型方面需要专业知识和建议，以加强/扩大他们的研究计划。CORE C旨在：(A)利用传染病发病机制的动物模型为项目负责人和其他中心研究人员提供技术、方法和分析支持；(B)提供资源和专业知识，协助中心研究人员利用和/或开发新的动物模型，以加强或扩大他们的研究计划；(C)为中心研究人员访问BSL-3和ABSL-2动物研究设施提供便利，并协助制定方案并确保在任何动物使用之前已获得批准。 科布雷II 本报告年度标志着Cobre II的第二个全年，核心C取代了BSL-3核心(核心D)，并从BSL-3核心(核心D)过渡而来，这是最初的Cobre I的一部分。核心C的发展和扩大是在2008年秋季审查期间与东非共同体进行广泛讨论的结果。根据东非共同体成员和科布雷II项目负责人的意见，动物模型核心被概念化并创建。核心C继续在科布雷一世期间完成和开始的早期工作中取得进展，并从早期工作中受益。从这个时代开始，建立了BSL-3核心，以开发人畜共患病研究中心调查人员进行BSL-3生物研究所需的必要资源和设施。该中心在科布雷第一次会议期间完成了最先进的BSL-3设施的建设，该设施的建成和CDC认证使我们能够直接进入BSL-3方面的布鲁氏菌和柯克斯氏菌致病方面的项目，这些项目由NIH落基山生物防御卓越研究中心资助。此外，这一设施的提供使我们能够成功竞争国家补充和替代医学中心的NIH项目，该项目是一项为期五年的天然产品在减少传染病和自身免疫性疾病方面的影响研究。在以下各节中，次级项目进度报告记录了核心C如何在过去的成功基础上继续发展，并从其重组中受益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, and assist in protocol preparation and insure approvals are on file prior to any animal use. COBRE II This reporting year marks the second full year of COBRE II, where Core C replaced and transitioned from the BSL-3 Core (Core D), which was part of the initial COBRE I. The development and expansion of Core C was the result of extensive discussion with the EAC during the Fall 2008 review. Based on input from the EAC members and the COBRE II Project Leaders, the Animal Models Core was conceptualized and created. Core C continues to make strides on and benefits from the earlier work completed and started during COBRE I. From this era, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five-year study of natural products' impact on reducing infectious and autoimmune diseases. In the following sections, the subproject progress report documents how Core C continued to build on past successes and benefitted from its reorganization.