MT VET COBRE II CORE C: ANIMAL MODELS

MT VET COBRE II CORE C：动物模型

• 批准号: 8168414
• 负责人: David W Pascual
• 金额: $ 14.41万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168414
• 关键词: Animal Model; Animals; Arts; Autoimmune Diseases; Biological Factors; Brucella; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Certification; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Coxiella; Development; Disease; Equipment; Funding; Future; Goals; Grant; Institution; Investments; Laboratories; Laboratory Animal Production and Facilities; Leadership; National Center for Complementary and Alternative Medicine; Organism; Pathogenesis; Preparation; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; base; biodefense; biosafety level 3 facility; design; falls; member; methionylmethionine; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, assist in animal protocol preparation, and insure approvals are on file prior to any animal use. COBRE I to COBRE II Transition The development of Core C represents a natural transition from the COBRE I BSL-3 Core (Core D). During COBRE I, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. While COBRE funds were not used for the construction, the COBRE I BSL-3 Core provided resources for several key pieces of equipment to outfit the BSL-3 laboratories. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five year study of natural products' impact on reducing infectious and autoimmune diseases. Thus, a small investment of COBRE I resources resulted in funding of major program grants for Center investigators to work on BSL-3 diseases, which was an important goal of COBRE I. With completion of the goals of the current Core, the COBRE leadership and EAC considered the future direction this Core should take in COBRE II, and this was discussed extensively during the Fall 2008 EAC review. Based on input from COBRE II Project Leaders and the EAC members, we revised the scope of this Core creating the new Animal Models Core.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 动物模型核心（Core C）由David Pascual博士指导，并提供资源和专业知识，以满足Cobre II初级调查人员和与该中心相关的其他研究人员的需求，他们建议在其研究中利用动物模型，并需要专业知识和建议，以实施新的动物模型来增强他们的研究/扩展研究计划。 Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, assist in animal protocol preparation, and insure approvals are on file在任何动物使用之前。 毛线i到鞋底II过渡 核心C的发展代表了从毛线I BSL-3核心（核心D）的自然过渡。在Cobre I期间，建立了BSL-3核心，以开发人畜共患病研究中心研究人员所需的必要资源和设施，以进行BSL-3生物的研究。该中心完成了Cobre I期间最先进的BSL-3设施的建设。尽管毛线资金未用于建造，但Cobre I BSL-3核心为几个关键设备提供了资源，以配备BSL-3实验室。该设施的完成和CDC认证使我们能够直接进入BSL-3方面的布鲁氏菌和Coxiella发病机理的项目，这些项目是通过NIH落基山山研究中心（NIH Rocky Mountain Research Center of Biodefense）资助的。此外，该设施的可用性使我们能够从国家互补和替代医学中心成功竞争NIH计划项目，这是对自然产品对减少感染和自身免疫性疾病的影响的五年研究。因此，一笔少量的COBRE I资源投资为中心研究人员提供了重大计划赠款的资助，以解决BSL-3疾病，这是Cobre I. I. I.的重要目标，这是当前核心的目标，Cobre Leadersion，Cobre Leadership和EAC认为，该核心应在Cobre II中进行讨论，并在2008年秋季EAC审查中进行了广泛的讨论。根据Cobre II项目负责人和EAC成员的意见，我们修改了该核心的范围，创建了新的动物模型核心。