MT VET COBRE II CORE C: ANIMAL MODELS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 动物模型核心(核心C)由David Pascual博士指导，提供资源和专业知识，以满足Cobre II初级调查人员和与中心相关的其他调查人员的需求，这些调查人员建议在他们的研究中利用动物模型和/或在实施新的动物模型方面需要专业知识和建议，以加强/扩大他们的研究计划。核心C旨在：(A)利用传染病发病机制的动物模型为项目负责人和其他中心研究人员提供技术、方法和分析支持；(B)提供资源和专业知识，协助中心研究人员利用和/或开发新的动物模型，以加强或扩大他们的研究计划；(C)为中心研究人员访问BSL-3和ABSL-2动物研究设施提供便利，协助制定动物方案，并确保在任何动物使用之前已获得批准。 科布雷一号到科布雷二号的过渡 C芯的发展代表着从Cobre I BSL-3芯(D芯)的自然过渡。在科布雷第一次会议期间，建立了BSL-3核心，以开发必要的资源和设施，以供人畜共患病研究中心的调查人员进行BSL-3生物研究。该中心在科布雷第一次建造期间完成了最先进的BSL-3设施的建造，虽然科布雷的资金没有用于建设，但科布雷I BSL-3核心为装备BSL-3实验室的几个关键设备提供了资源。该设施的建成和疾控中心的认证使我们能够直接进入由NIH落基山生物防御卓越研究中心资助的布鲁氏菌和柯克斯氏菌致病方面的BSL-3方面项目。此外，这一设施的提供使我们能够成功竞争国家补充和替代医学中心的NIH项目，该项目是一项为期五年的天然产品在减少传染病和自身免疫性疾病方面的影响研究。因此，对Cobre I资源的一小笔投资导致为中心调查人员研究BSL-3疾病的主要计划赠款提供资金，这是Cobre I的一个重要目标。随着当前核心的目标的完成，Cobre领导层和EAC考虑了该核心在Cobre II中应采取的未来方向，这在2008年秋季的EAC审查期间进行了广泛讨论。根据Cobre II项目负责人和EAC成员的意见，我们修改了这个核心的范围，创建了新的动物模型核心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, assist in animal protocol preparation, and insure approvals are on file prior to any animal use. COBRE I to COBRE II Transition The development of Core C represents a natural transition from the COBRE I BSL-3 Core (Core D). During COBRE I, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. While COBRE funds were not used for the construction, the COBRE I BSL-3 Core provided resources for several key pieces of equipment to outfit the BSL-3 laboratories. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five year study of natural products' impact on reducing infectious and autoimmune diseases. Thus, a small investment of COBRE I resources resulted in funding of major program grants for Center investigators to work on BSL-3 diseases, which was an important goal of COBRE I. With completion of the goals of the current Core, the COBRE leadership and EAC considered the future direction this Core should take in COBRE II, and this was discussed extensively during the Fall 2008 EAC review. Based on input from COBRE II Project Leaders and the EAC members, we revised the scope of this Core creating the new Animal Models Core.