MT VET COBRE II CORE C: ANIMAL MODELS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 动物模型核心（核心C）由大卫帕斯夸尔博士指导，并提供资源和专业知识，以满足COBRE II初级研究者和与中心相关的其他研究者的需求，这些研究者建议在其研究中使用动物模型和/或在实施新动物模型方面需要专业知识和建议，以增强/扩展其研究计划。核心C旨在（a）为项目负责人和其他利用传染病发病机制动物模型的中心研究者提供技术、方法和分析支持，（B）提供资源和专业知识，以协助中心研究者利用和/或开发新的动物模型，以增强或扩展其研究计划，和（c）协助中心研究者访问BSL-3和ABSL-2动物研究机构，协助动物方案准备，并确保在使用任何动物之前将批准文件存档。 COBRE I到COBRE II的过渡 核心C的开发代表了COBRE I BSL-3核心（核心D）的自然过渡。在COBRE I期间，建立了BSL-3核心，以开发中心研究人员在人畜共患病研究中进行BSL-3生物研究所需的必要资源和设施。该中心在COBRE I期间完成了最先进的BSL-3设施的建设。虽然COBRE的资金没有用于建造，但COBRE I BSL-3核心为装备BSL-3实验室的几个关键设备提供了资源。该设施的完成和CDC认证使我们能够直接进入布鲁氏菌和柯克斯体发病机制的BSL-3方面项目，这些项目由NIH落基山生物防御卓越研究中心资助。此外，该设施的可用性使我们能够成功地竞争国家补充和替代医学中心的NIH计划项目，这是一项为期五年的天然产品对减少传染病和自身免疫性疾病的影响研究。因此，COBRE I资源的少量投资为中心研究人员研究BSL-3疾病提供了主要项目赠款，这是COBRE I的一个重要目标。随着当前核心目标的完成，COBRE领导层和EAC考虑了该核心在COBRE II中应采取的未来方向，并且在2008年秋季EAC审查期间对此进行了广泛讨论。根据COBRE II项目负责人和EAC成员的意见，我们修订了本核心的范围，创建了新的动物模型核心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, assist in animal protocol preparation, and insure approvals are on file prior to any animal use. COBRE I to COBRE II Transition The development of Core C represents a natural transition from the COBRE I BSL-3 Core (Core D). During COBRE I, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. While COBRE funds were not used for the construction, the COBRE I BSL-3 Core provided resources for several key pieces of equipment to outfit the BSL-3 laboratories. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five year study of natural products' impact on reducing infectious and autoimmune diseases. Thus, a small investment of COBRE I resources resulted in funding of major program grants for Center investigators to work on BSL-3 diseases, which was an important goal of COBRE I. With completion of the goals of the current Core, the COBRE leadership and EAC considered the future direction this Core should take in COBRE II, and this was discussed extensively during the Fall 2008 EAC review. Based on input from COBRE II Project Leaders and the EAC members, we revised the scope of this Core creating the new Animal Models Core.