IMPACT OF EARLY EXPERIENCE ON VULVOVAGINAL SENSITIVITY IN ADULT MOUSE

早期经验对成年小鼠外阴阴道敏感性的影响

• 批准号: 8360687
• 负责人: Julie A Carlsten Christianson
• 金额: $ 21.66万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360687
• 关键词: Ablation; Adult; Affect; Animal Model; Behavioral; Burn injury; Cells; Chemicals; Chronic; Comorbidity; Development; Esthesia; Event; Funding; Grant; Human; Incidence; Infant; Interstitial Cystitis; Irritable Bowel Syndrome; Life Experience; Literature; Methods; Modeling; Molecular; Mus; National Center for Research Resources; Neonatal; Nerve; Newborn Infant; Nociceptors; Pain; Pain Disorder; Physiological; Population; Preclinical Testing; Prevalence; Principal Investigator; Procedures; Publishing; Rattus; Regulation; Research; Research Infrastructure; Resources; Sensory; Source; Sting Injury; Stress; Symptoms; Syndrome; United States National Institutes of Health; Vagina; Vulva; Vulvodynia; Woman; chronic pain; chronic pelvic pain; cost; design; early experience; endometriosis; irritation; maternal separation; nerve supply; response; stressor; vulvar pain

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Early life experience has been shown to have a profound impact on the prevalence of chronic pain. Prematurely born infants are exposed to numerous stressors, including repeated invasive procedures and prolonged periods of maternal separation, and often later develop adverse behavioral and physiological responses to painful events, as well as have a higher incidence of some functional pain disorders. Newborn rats that undergo stress or repeated painful procedures similarly develop chronic pain as adults. This study is designed to 1) determine how neonatal stress or irritation affects the sensitivity and sensory innervation of the vulva and vagina, and 2) employ a method to selectively remove the nerves responsible for pain sensations as a preclinical test for treating vulvodynia in humans. Vulvodynia affects an estimated 15% of women and is clinically defined as chronic discomfort or pain of the vulva, often occurring as burning, stinging or soreness. Little is known regarding potential changes in the nerves that supply this region and no animal models exist in the current literature. Successful completion of these studies will not only provide the first published model of vulvodynia, but is also the first step in developing a new class of compounds that alleviates chronic pelvic pain without affecting normal sensations. Considering the high degree of comorbidity between vulvodynia and other chronic pelvic pain syndromes, e.g. endometriosis, irritable bowel syndrome and interstitial cystitis, chemical ablation of this population of nociceptors could also alleviate symptoms of these syndromes, as well.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 早期生活经历已被证明对慢性疼痛的患病率具有深远的影响。早产儿面临许多压力源，包括重复的侵入性操作和长时间的母体分离，并且通常随后会对疼痛事件产生不良的行为和生理反应，并且某些功能性疼痛疾病的发生率较高。 承受压力或重复痛苦过程的新生大鼠与成年大鼠类似地会出现慢性疼痛。 本研究旨在 1) 确定新生儿应激或刺激如何影响外阴和阴道的敏感性和感觉神经支配，2) 采用一种方法选择性地去除负责疼痛感觉的神经，作为治疗人类外阴痛的临床前测试。 据估计，外阴痛影响 15% 的女性，临床上定义为外阴慢性不适或疼痛，通常表现为烧灼感、刺痛或酸痛。关于供应该区域的神经的潜在变化知之甚少，并且当前文献中不存在动物模型。这些研究的成功完成不仅将提供第一个发表的外阴痛模型，而且也是开发一类新化合物的第一步，该化合物可减轻慢性盆腔疼痛而不影响正常感觉。考虑到外阴痛和其他慢性盆腔疼痛综合征之间的高度合并症，例如子宫内膜异位症、肠易激综合征和间质性膀胱炎，对这些伤害感受器进行化学消融也可以减轻这些综合征的症状。