CLINICAL RESEARCH CORE

临床研究核心

• 批准号: 8292057
• 负责人: Jeff Douglas Williamson
• 金额: $ 19.23万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8292057
• 关键词: Address; Adipose tissue; Affect; American; Award; Basic Science; Biometry; Biostatistics Core; Blood; Blood specimen; Budgets; Clinical Research; Clinical Trials; Clinical Trials Design; Computers; Databases; Development; Elderly; Ensure; Epidemiologic Studies; Faculty; Funding; Grant; Health Insurance Portability and Accountability Act; Institutional Review Boards; Intervention; K-Series Research Career Programs; Leadership; Maintenance; Measurement; Measures; Mentors; Methodology; Minority; Molecular; Monitor; Muscle; Obesity; Observational Study; Outcome; Outcome Measure; Participant; Pathway interactions; Patient Self-Report; Phenotype; Physical Function; Pilot Projects; Positioning Attribute; Prevention; Process; Psychometrics; Publications; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Science; Services; Techniques; Testing; Tissue Procurements; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Woman; animation; base; career development; clinically relevant; data management; disability; experience; forest; human population study; implementation research; innovation; meetings; member; novel; novel strategies; prevent; programs; research and development; research study; sarcopenia

The Clinical Research Core (CRC - Resource Core 1) of the Wake Forest University Older Americans Independence Center (WFU OAIC) provides the critical infrastructure and investigator resources essential to the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (Biolmaging, Molecular Sciences, and the Biostatistics and Data Management Cores). With them, the CRC will support NIH-funded independent studies, OAlC-funded pilot and Research Career Development Studies, and other externally-funded projects related to the WFU OAIC research theme: Integrating pathways affecting physical function for new approaches to disability prevention. A high priority for the CRC will be to support clinical trials translating basic research discoveries into human population studies; clinical research targeting sarcopenia and adiposity-related decline in physical function and disability in older adults; and trials of novel interventions related to these risk factors. The CRC will also assfst the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the Research Career Development Core (RCDC) in identifying promising new and established investigators and programs positioned to help to address the mechanisms and prevention of physical disability. The CRC will provide 'turn-key' resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures; 2) highly efficient and effective participant recruitment, including women and minorities; 3) a standardized physical function assessment battery; 4) procurement, storage, and analysis (with the Molecular Sciences Core) of muscle and adipose tissue and blood samples; 5) maintenance (in concert with the Biostatistics Core) of a uniform outcomes database; 6) assisting junior investigators with IRB and other regulatory filings (in concert with the PESC and RCDC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grant awards, and development of new investigators. The CRC leadership team is highly experienced in clinical trial design and implementation, research focused on physical function in older adults, and successful mentoring for junior investigators. In the first year of funding, the Core will support 9 studies: five investigator-initiated clinical trials, an observational study, a pilot study, a research development project, and a research career development award.

维克森林大学老年美国人临床研究核心（CRC -资源核心1） 独立中心（WFU OAIC）提供关键的基础设施和调查人员资源， 成功开展了以老年人身体功能和残疾为重点的临床研究。的 CRC与其他OAIC资源核心（生物成像、分子科学和 生物统计学和数据管理核心）。与他们一起，CRC将支持NIH资助的独立 研究、由禁毒办资助的先导计划、研究人员职业发展研究，以及其他由外界资助的计划 与WFU OAIC研究主题有关：整合影响新的身体功能的途径 预防残疾的方法。 CRC的一个高度优先事项将是支持将基础研究发现转化为人类的临床试验 人群研究;针对肌肉减少症和肥胖相关身体功能下降的临床研究 和老年人的残疾;以及与这些风险因素相关的新干预措施的试验。CRC还将 assfst领导和行政核心（LAC），试点和探索性研究核心（PESC），以及 研究职业发展核心（RCDC），以确定有前途的新的和建立的研究人员 以及旨在帮助解决身体残疾的机制和预防的方案。的CRC 将为成功的临床研究提供关键的“交钥匙”资源，包括：1）与 实验研究的设计和进行，包括选择适当的结果措施; 2）高度 高效率和高成效地征聘参与者，包括妇女和少数民族; 3）标准化体检 功能评估电池; 4）采购，储存和分析（与分子科学核心） 肌肉和脂肪组织以及血液样本; 5）维持（与生物统计学核心一致） 统一的结局数据库; 6）协助初级研究者处理IRB和其他监管文件（一致） 与PESC和RCDC）。在本周期内，提供这些关键资源是我们 及时完成临床研究，公布结果，竞争新的独立资助赠款 奖励和新调查员的发展。CRC领导团队在临床方面经验丰富， 试验设计和实施，研究重点是老年人的身体功能， 为初级调查员提供指导。在资助的第一年，核心基金将资助9项研究： 制药商发起的临床试验、观察性研究、先导性研究、研发项目，以及 研究职业发展奖。