CLINICAL RESEARCH CORE

维克森林大学美国老年人的临床研究核心(CRC-资源核心1) 独立中心(WFU OAIC)提供关键基础设施和调查人员资源 成功开展了以老年人身体功能和残疾为重点的临床研究。这个 CRC与其他OAIC资源核心(生物成像、分子科学和 生物统计和数据管理核心)。有了他们，CRC将支持NIH资助的独立 研究，OALC资助的试点和研究职业发展研究，以及其他外部资助的项目 与WFU OAIC研究主题相关：整合影响新的身体功能的途径 残疾预防的方法。 CRC的一个高度优先事项是支持将基础研究发现转化为人类的临床试验 人群研究；针对骨质疏松症和肥胖相关的身体功能下降的临床研究 以及与这些风险因素相关的新干预措施的试验。儿童权利委员会还将 领导和行政核心(LAC)、试点和探索性研究核心(PESC)以及 研究职业发展核心(RCDC)在寻找有前途的新老研究人员方面 以及旨在帮助解决身体残疾的机制和预防的方案。《儿童权利公约》 将提供对成功的临床研究至关重要的“交钥匙”资源，包括：1)相关的专业知识 设计和实施实验研究，包括选择适当的结果衡量标准；2)高度 高效率和有效的参与者招募，包括妇女和少数群体；3)标准化体检 功能评估电池；4)采购、储存和分析(与分子科学核心) 肌肉、脂肪组织和血液样本；5)维护(与生物统计核心协调) 统一结果数据库；6)协助初级调查员处理内部审查委员会和其他监管文件(协调一致 与PESC和RCDC合作)。在本周期内，提供这些关键资源一直是我们 及时完成临床研究，公布结果，竞争新的独立资助拨款 奖项，以及新调查人员的发展。CRC领导团队在临床方面经验丰富 试验设计和实施，研究重点是老年人的身体功能，并取得成功 初级调查员的指导。在资助的第一年，核心将支持9项研究：5项 研究人员发起的临床试验、观察性研究、先导性研究、研究开发项目，以及 研究事业发展奖。

The Clinical Research Core (CRC - Resource Core 1) of the Wake Forest University Older Americans Independence Center (WFU OAIC) provides the critical infrastructure and investigator resources essential to the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (Biolmaging, Molecular Sciences, and the Biostatistics and Data Management Cores). With them, the CRC will support NIH-funded independent studies, OAlC-funded pilot and Research Career Development Studies, and other externally-funded projects related to the WFU OAIC research theme: Integrating pathways affecting physical function for new approaches to disability prevention. A high priority for the CRC will be to support clinical trials translating basic research discoveries into human population studies; clinical research targeting sarcopenia and adiposity-related decline in physical function and disability in older adults; and trials of novel interventions related to these risk factors. The CRC will also assfst the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the Research Career Development Core (RCDC) in identifying promising new and established investigators and programs positioned to help to address the mechanisms and prevention of physical disability. The CRC will provide 'turn-key' resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures; 2) highly efficient and effective participant recruitment, including women and minorities; 3) a standardized physical function assessment battery; 4) procurement, storage, and analysis (with the Molecular Sciences Core) of muscle and adipose tissue and blood samples; 5) maintenance (in concert with the Biostatistics Core) of a uniform outcomes database; 6) assisting junior investigators with IRB and other regulatory filings (in concert with the PESC and RCDC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grant awards, and development of new investigators. The CRC leadership team is highly experienced in clinical trial design and implementation, research focused on physical function in older adults, and successful mentoring for junior investigators. In the first year of funding, the Core will support 9 studies: five investigator-initiated clinical trials, an observational study, a pilot study, a research development project, and a research career development award.