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Functional Neuroanatomy of Human Fear Conditioning

人类恐惧调节的功能神经解剖学

基本信息

批准号：
8136280
负责人：
FRED J HELMSTETTER
金额：
$ 26.2万
依托单位：
UNIVERSITY OF WISCONSIN MILWAUKEE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-03-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8136280
关键词：
Address Affect Amygdaloid structure Anxiety Area Association Learning Auditory Autonomic nervous system Awareness Basic Science Brain Brain Mapping Brain region Clinical Cognitive Development Disease Dissociation Emotions Expectancy Experimental Designs Exposure to Extinction (Psychology)Fright Functional Magnetic Resonance Imaging Funding Goals Hippocampus (Brain)Human Knowledge Laboratory Animal Models Laboratory Animals Learning Medial Memory Middle frontal gyrus structure Molecular Nature Nervous system structure Neuroanatomy Neurobiology Organism Pattern Performance Phase Physical environment Predictive Value Prefrontal Cortex Procedures Process Relative (related person)Research Retrieval Role Series Shock Signal Transduction Somatosensory Cortex Stimulus Structure System Techniques Temporal Lobe Testing Time Translating Visual Work base cingulate cortex classical conditioning comparative conditioned fear conditioning frontal lobe human subject improved indexing insight learning extinction long term memory memory process memory retrieval neuromechanism patient population procedural memory programs relating to nervous system research study response sensory cortex visual stimulus

项目摘要

DESCRIPTION (provided by applicant): Multiple neural systems exist within the human brain that allow us to learn and remember. At the present time it is not entirely clear how the many different forms of human memory relate directly to structures and circuits in the brain. The long-term goal of this study is to understand the neural mechanisms underlying a specific form of memory, aversive Pavlovian conditioning, in human subjects. The ability to learn associations through Pavlovian conditioning is shared by a wide variety of organisms but very little is known about the neurobiological substrates of this process in humans. Our general approach is to use state of the art whole brain functional magnetic resonance imaging (fMRI) to identify brain regions and circuits that contribute to the acquisition and performance of fear conditioning. Functional maps of brain areas in which activity is directly related to exposure to the CS+ or CS- in a differential conditioning paradigm will be constructed. Similar techniques are used to characterize brain areas in which activity is best related to autonomic fear responses versus cognitive awareness of the relationship between programmed stimuli. This phase of the project will focus on a series of predictions regarding the roles of the amygdala, hippocampus, frontal cortex, and cingulate cortex based on our progress during the last funding period and current knowledge from laboratory animal studies and other human memory paradigms. We will further evaluate our findings related to localized frontal lobe activity specifically related to contingency awareness and declarative memory. We will explore the dynamics of learning-related stimulus representations in primary sensory cortex. We will compare an auditory fear conditioning procedure with visual stimulus conditioning, and we will conduct studies related the mechanisms of fear extinction and long-term memory retrieval. The results will enable significant advancement in understanding; 1) the relationship between declarative and procedural memory systems, 2) the role of awareness in learning, 3) the comparative neuroanatomy of memory, and 4) the brain mechanisms of fear and anxiety. Our work should be particularly useful in improving the ability to translate fundamental results from laboratory animal models of memory and emotion directly to healthy humans as well as patient populations. The research described here has direct implications for understanding basic brain mechanisms of memory and anxiety in humans. This work may provide valuable insights into new treatments for diseases and disorders that affect memory and emotion. Our approach to these issues represents an important step toward the application of a large body of basic research in laboratory animals to clinical and experimental questions in people.

描述（由申请人提供）：人类大脑中存在多个神经系统，使我们能够学习和记忆。目前还不完全清楚人类记忆的许多不同形式是如何与大脑的结构和回路直接联系起来的。这项研究的长期目标是了解人类受试者的一种特定记忆形式——厌恶的巴甫洛夫条件反射——背后的神经机制。通过巴甫洛夫条件反射学习关联的能力为多种生物体所共有，但对人类这一过程的神经生物学基础知之甚少。