Consortium study of modifiable causes of death in Asians

亚洲人可改变死因的联合研究

• 批准号: 8117475
• 负责人: JOHN D POTTER
• 金额: $ 8.54万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8117475
• 关键词: Address; Alcohol consumption; Asia; Asian Americans; Asians; Body mass index; Cancer Etiology; Cardiovascular Diseases; Cause of Death; Central obesity; Cessation of life; Chronic Disease; Cohort Studies; Collaborations; Country; Data; Epidemic; Europe; Goals; Health; Heavy Drinking; Life Style; Link; Malignant Neoplasms; Measurement; Measures; Methodology; Modeling; NCI Consortium or Network; Non obese; North America; Obesity; Outcome; Physical activity; Policies; Population; Prevalence; Public Health; Research; Research Infrastructure; Risk; Risk Factors; Sample Size; Waist-Hip Ratio; adverse outcome; cigarette smoking; cohort; disorder prevention; disorder risk; improved; lifestyle factors; mortality; premature; programs

DESCRIPTION (provided by applicant): Asians constitute over 60% of the world's population. Over the past few decades, the burden of chronic diseases, particularly cardiovascular disease (CVD) and cancer, has increased substantially in Asian countries as a consequence of adverse lifestyle changes, including reduced physical activity, increased prevalence of obesity, cigarette smoking, and heavy alcohol consumption. Although each of the above modifiable factors has been linked to premature death, the overall impact of these factors on total and cause-specific mortality is unclear, particularly in the Asian populations. In 2008, we proposed, and have now successfully completed, the first analysis project in the Asia Cohort Consortium (ACC): to quantify the association between body mass index (BMI) and both total and cause-specific mortality by pooling and harmonizing data from over one million subjects across 18 cohort studies being conducted in Asian countries. In this application, we propose to expand the BMI pooling project to address study questions related to central obesity and other modifiable causes of death in Asians. We propose the following specific aims: 1) To evaluate the association between central obesity, as measured by waist-to-hip ratio (WHR), and both total and cause-specific mortality; and 2) To quantify the impact of major modifiable lifestyle factors, including high BMI, high WHR, cigarette smoking, and excessive alcohol drinking on both total and cause-specific mortality. Our consortium addresses the NCI objective to "expand the capacity of centers, networks, and consortia," and the goal to "create and sustain infrastructures that facilitate research collaboration" as outlined in the NCI Plans and Priorities. We anticipate that the analysis within the ACC will be a major step toward improving understanding of the causes and mechanisms of cancers and will enhance the collaboration within the consortium for further pooled analyses. The proposed study will generate substantial data that are valuable to inform policies and programs aimed at tackling the emerging epidemic of chronic diseases and to reduce premature death in Asian countries.

描述（由申请人提供）：亚洲人占世界人口的60％以上。在过去的几十年中，由于不利的生活方式改变，包括体育锻炼的不良，肥胖症，吸烟和大量饮酒，慢性疾病的负担，尤其是心血管疾病（CVD）和癌症的负担在亚洲国家大大增加。尽管上述每个可修改因素都与过早死亡有关，但这些因素对总和特定死亡率的总体影响尚不清楚，尤其是在亚洲人群中。在2008年，我们提出并已经成功完成了亚洲队列联盟（ACC）中的第一个分析项目：量化体重指数（BMI）与总和在亚洲国家进行的18个队列研究中超过一百万个受试者的一百万受试者的数据和协调数据之间的体重指数（BMI）与总和特定的数据之间的关联。在此应用程序中，我们建议扩大BMI POOL计划，以解决与中央肥胖和亚洲人其他可修改的死亡原因有关的研究问题。我们提出以下具体目的：1）评估通过腰围比（WHR）衡量的中央肥胖之间的关联，以及总和特定的死亡率；和2）量化主要可修改的生活方式因素的影响，包括高BMI，高WHR，吸烟和过量饮酒对总和特定原因的死亡率。我们的财团探讨了NCI的目标，以“扩大中心，网络和财团的能力”，以及NCI计划和优先事项中概述的“创建和维持促进研究合作的基础设施”的目标。我们预计，ACC内的分析将是提高对癌症原因和机制的理解的重要一步，并将增强财团内的协作以进行进一步的汇总分析。拟议的研究将产生大量数据，这些数据有价值，可为旨在解决慢性疾病的新兴流行并减少亚洲国家的过早死亡的政策和计划。