Multi-Center Study of Pancratic Cancer Etiology

胰腺癌病因多中心研究

• 批准号: 6921997
• 负责人: JOHN D POTTER
• 金额: $ 109.29万
• 依托单位: KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6921997
• 关键词: African American; biomarker; cancer risk; clinical research; diabetes mellitus; disease /disorder etiology; disease /disorder onset; early diagnosis; gene environment interaction; genetic polymorphism; genetic susceptibility; human subject; insulin sensitivity /resistance; interview; managed care; medical records; pancreas neoplasms; racial /ethnic difference; smoking; tobacco abuse

DESCRIPTION (provided by applicant): Risk factors for pancreas cancer are not well established. Because of its near uniform and rapid case fatality, most studies of pancreas cancer have been small, had modest response rates and/or collected data exclusively from a surrogate respondent, and had limited, if any, biologic samples for molecular analysis. The long-term goal of this project is to investigate a wide range of environmental and genetic factors in order to improve our understanding of pancreas cancer etiology, beginning with a large, case-control study based on direct participant interview, electronic medical record review and blood sampling. We propose to conduct a case-control study of pancreas cancer, comprised of 745 cases and 745 controls in the defined populations of two health maintenance organizations (HMO) that have computerized administrative and clinical data to support "ultra-rapid" case identification within ten working days of diagnosis. To maximize statistical power to investigate differences in risk by race, we will assemble a second control group of 296 African-Americans matched to the expected 74 African- American cases using a 4:1 ratio. Given the large effort required to assemble these data, we propose to address an extensive set of specific aims: 1) To investigate the relation between diabetes and pancreas cancer risk, focusing on age at diabetes onset and type of diabetes, based on interview and electronic medical record data; 2) To investigate the relation between pancreas cancer and diet focusing on factors that influence insulin resistance and factors that influence methyl group availability; 3) To investigate the relation between use of non-steroidal anti-inflammatory drugs and pancreas cancer risk; 4) To investigate the relation between direct and environmental exposure to tobacco and pancreas cancer risk; 5) To characterize the familial aggregation of pancreas cancer; and 6) To establish a study biorepository for use in future studies of genetic polymorphisms, biomarkers, and gene-environment interactions in relation to risk of pancreas cancer. The proposed study will result in a large sample of newly diagnosed cases and will establish a unique and comprehensive resource for future epidemiologic, molecular, and genetic investigations. Results from this study will lead to improved understanding of pancreas cancer risk factors and the molecular events leading to the development of pancreas cancer, which are both imperative for effective strategies for prevention and early diagnosis.

描述（由申请人提供）：胰腺癌的危险因素尚未确定。由于其几乎均匀且迅速的病例死亡，大多数胰腺癌研究都很小，反应率适度和/或仅从替代受访者那里收集的数据，并且有限（如果有的话）生物样品进行分子分析。该项目的长期目标是研究广泛的环境和遗传因素，以提高我们对胰腺癌病因的理解，从基于直接参与者访谈，电子病历审查和血液采样的大型病例对照研究开始。我们建议对胰腺癌进行病例对照研究，其中包括745例病例和745例对照组成的两个健康维护组织（HMO）的人群中具有计算机化的行政和临床数据，以支持“超拉皮德”病例识别诊断的十个工作日。为了最大程度地提高统计能力以调查种族风险的差异，我们将使用4：1的比率组装一个与预期的74个非裔美国人案件相匹配的296名非裔美国人的对照组。 鉴于组装这些数据所需的巨大努力，我们建议解决一组广泛的特定目的：1）研究糖尿病与胰腺癌风险之间的关系，重点关注糖尿病发作和糖尿病类型的年龄，基于面试和电子病理记录数据； 2）研究胰腺癌与饮食之间的关系，重点关注影响胰岛素抵抗的因素和影响甲基供应性的因素； 3）研究使用非甾体类抗炎药与胰腺癌风险之间的关系； 4）研究直接与环境暴露于烟草和胰腺癌风险之间的关系； 5）表征胰腺癌的家族聚集；和6）建立研究生物措施，以用于对遗传多态性，生物标志物和基因环境相互作用的未来研究，以与胰腺癌的风险有关。拟议的研究将导致大量新诊断的病例样本，并将为未来的流行病学，分子和遗传研究建立独特而全面的资源。这项研究的结果将导致人们对胰腺癌危险因素的了解以及导致胰腺癌发展的分子事件的了解，这对于有效的预防和早期诊断策略至关重要。