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Cell and Virus CORE

Cell and Virus CORE
细胞和病毒核心
批准号：
7903236
负责人：
David J Rawlings
金额：
$82.21万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-09-30 至 2012-06-30
来源：
https://reporter.nih.gov/project-details/7903236
关键词：
AffinityAvidityB-LymphocytesBindingBiological AssayCalibrationCapitalCell LineCell SeparationCellsCultured CellsEngraftmentEquipmentFamiliarityFlow CytometryGene TargetingGenerationsHematopoieticHourHuman ResourcesImmuneImmune systemImmunoglobulin Somatic HypermutationImmunologyIndividualLaboratoriesLentivirus VectorLibrariesMagnetismMaintenanceMethodsPediatric HospitalsProductionProteinsReporterResearch PersonnelScreening procedureSideSiteSorting - Cell MovementSupporting CellSurfaceTechnologyTimeVariantViralbasecostdesigngene repairimmune functionin vivoinstrumentinstrumentationmagnetic cell separationreconstitutionrepairedresearch studystem cell populationvirus core

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中文摘要
翻译
细胞和病毒核心的设计是为了支持NGEC的两个主要活动：细胞分离和
英文摘要
The Cell and Virus Core is designed to support two major activities of the NGEC: cell separations and analysis, and construction and production of self inactivating non-integrating lentiviral (NIL) vectors and viral stocks. AutoMACs and flow cytometry and sorting will be heavily utilized in Components 2-5 for LHE design, and in Components 6-8 for analysis of fluorescent reporter assays and immune function in in vivo gene targeting and repair experiments. NIL vectors will be used for delivery of LHE's and donor templates in selected experiments from Component 1, and in virtually all experiments proposed in Components 6-8.
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