Core--Immune Function Studies

核心--免疫功能研究

• 批准号: 7478454
• 负责人: David J Rawlings
• 金额: $ 9.66万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7478454
• 关键词: B cell differentiation; Data; Data Analyses; Family; Flow Cytometry; Human Resources; Immune; Immune response; Measurement; Morbidity - disease rate; Observational Study; Outcome; Patients; Peripheral Blood Mononuclear Cell; Research Personnel; Serum; Sorting - Cell Movement; T-Lymphocyte; T-Lymphocyte Subsets; TNF gene; Transplantation; design; immune function; reconstitution; research clinical testing

The Immune Function Studies Core is designed to support observational studies of post-transplantation immune reconstitution. The Core will perform multi-parameter flow cytometry analyses of T-cell and B-cell differentiation, sjTREC quantitation on PBMC or flow sorted T-cell subsets, and measurements of serum levels of Blys-April TNF family immunoregulatory factors. Core personnel will also be available to aid project investigators in the analysis and interpretation of multiparameter flow cytometry data. The data from these analyses will be used to define the course and extent of post-transplantation immune reconstitution, and will be correlated with the results from clinical evaluations of immune responses, patient morbidity, and graft outcome.

免疫功能研究核心旨在支持移植后的观察性研究 免疫重建。核心将执行 T细胞和B细胞分化的多参数流式细胞术分析， PBMC或流式分选的T细胞亚群，以及Blys-April TNF家族的血清水平的测量 免疫调节因子核心人员还将在以下方面协助项目调查人员： 多参数流式细胞术数据的分析和解释。这些分析的数据将 用于定义移植后免疫重建的过程和程度，并将与 其结果来自免疫应答、患者发病率和移植结果的临床评估。