Auditory Cortex Structure and Function in Schizophrenia

精神分裂症的听觉皮层结构和功能

• 批准号: 8073962
• 负责人: James Christopher EDGAR
• 金额: $ 16.82万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-18 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073962
• 关键词: Accounting; Agreement; Area; Attention; Auditory; Auditory Perceptual Disorders; Auditory area; Auditory system; Behavioral; Belief; Biological Markers; Biological Neural Networks; Brain; Brain region; Clinical; Cognition; Cognitive; Complement; Data; Ear; Electroencephalography; Foundations; Frequencies; Functional disorder; Goals; Hand; Health; Impaired cognition; Individual; Intervention; Knowledge; Left; Magnetoencephalography; Measures; Methods; Modeling; Molecular and Cellular Biology; Nature; Nervous system structure; Outpatients; Pathway interactions; Patients; Performance; Pharmaceutical Preparations; Phase; Process; Reporting; Research; Research Design; Research Training; Running; Schizophrenia; Source; Stimulus; Structure; Study Section; Suggestion; Sum; Superior temporal gyrus; Symptoms; Techniques; Testing; Time; Training; Treatment Efficacy; Work; atypical antipsychotic; auditory stimulus; base; clinically significant; computerized data processing; deviant; functional group; improved; novel; relating to nervous system; response; sensor

DESCRIPTION (provided by applicant): A deficit in the capacity to process auditory information has been proposed as one of the core abnormalities in schizophrenia (Sz). Despite the importance of the subject, we know little about the mechanisms underlying normal or disordered auditory processing, or about the clinical significance of auditory deficits. Research focuses increasingly on the time-frequency brain activity associated with auditory processes, as it's hypothesized that single-trial amplitude and phase measures more closely reflect neural processes. As detailed throughout this K08 proposal, my recent superior temporal gyrus (STG) timefrequency findings build upon and greatly extend findings in this area of research, and present results indicate several clear lines of research where advances in the understanding and treatment of Sz are likely. For the K08 study, using novel tasks developed for this K08 project, functional measures (electroencephalography and magnetoencephalography) of auditory activity throughout the brain will be obtained with 50 controls and 50 patients. There are 3 substantive research goals: (1) determine the nature of auditory abnormalities in Sz by examining multiple nodes in the auditory network and by multiply assessing each processes (encoding vs. gating, amplitude vs. phase-locking), (2) determine whether the abnormal auditory processes can be normalized in patients with Sz by varying attention aI/task-set requirements, and (3) determine the clinical significance of the observed abnormalities. An encoding phase-locking deficit is hypothesized, and it is hypothesized that this abnormality is associated with cognitive problems and increased negative symptoms. K08 training complements K08 research. Primary K08 training goals include: (1) study of several novel distributed source localization methods and advanced time-frequency signal processing techniques in order to examine auditory activity throughout the brain, and (2) classroom work on relevant cellular and molecular biology of the nervous system and the neural processes that underlie emergent oscillatory activity. These methods and data will form the foundation of a R01 that seeks to normalize auditory dysfunction in Sz. PUBLIC HEALTH RELEVANCE: Many individuals with schizophrenia show abnormal brain activity when processing auditory stimuli. We know little about the mechanisms underlying normal or disordered auditory processing. The proposed project uses non-invasive techniques to increase our knowledge of the function of auditory areas in controls and in individuals with schizophrenia. The clinical significance of these abnormalities is also examined.

描述（由申请人提供）：处理听觉信息的能力缺陷被认为是精神分裂症（Sz）的核心异常之一。尽管这一主题很重要，但我们对正常或紊乱的听觉处理机制以及听觉缺陷的临床意义知之甚少。研究越来越多地关注与听觉过程相关的时频大脑活动，因为它假设单次试验的幅度和相位测量更能反映神经过程。正如在K 08的建议中所详述的，我最近的上级颞回（STG）时频研究结果建立在这一研究领域的基础上，并大大扩展了这一领域的研究结果，目前的研究结果表明，在理解和治疗Sz方面可能有几条明确的研究路线。对于K 08研究，使用为本K 08项目开发的新任务，将获得50名对照和50名患者的整个大脑听觉活动的功能测量（脑电图和脑磁图）。有三个实质性的研究目标：（1）通过检查听觉网络中的多个节点并通过多次评估每个过程来确定Sz中听觉异常的性质（编码与门控，振幅与相位锁定），（2）确定是否可以通过改变注意力/任务集要求来使Sz患者的异常听觉过程正常化，以及（3）确定所观察到的异常的临床意义。假设编码锁相缺陷，并假设这种异常与认知问题和阴性症状增加有关。K 08培训补充K 08研究。主要的K 08培训目标包括：（1）研究几种新的分布式源定位方法和先进的时频信号处理技术，以检查整个大脑的听觉活动，以及（2）神经系统和神经过程的相关细胞和分子生物学的课堂工作，这些神经过程是紧急振荡活动的基础。这些方法和数据将形成R 01的基础，该R 01旨在使Sz的听觉功能障碍正常化。 公共卫生相关性：许多精神分裂症患者在处理听觉刺激时表现出异常的大脑活动。我们对正常或紊乱的听觉处理机制知之甚少。拟议的项目使用非侵入性技术，以增加我们的知识，在控制和精神分裂症患者的听觉区的功能。这些异常的临床意义也进行了检查。