Women's Reproductive Health Research Career Development Program at W.U., St Louis

圣路易斯 W.U. 妇女生殖健康研究职业发展计划

• 批准号: 8136292
• 负责人: GEORGE A MACONES
• 金额: $ 47.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136292
• 关键词: Area; Barker Hypothesis; Basic Science; Biology; Biomedical Research; Clinical; Clinical Research; Clinical Sciences; Communicable Diseases; Complement; Contraceptive methods; Development; Developmental Biology; Discipline; Endometrial Carcinoma; Environment; Future; Goals; Health Benefit; Investigation; Leadership; Location; Mentors; Neurology; Pathway interactions; Performance; Physicians; Physiology; Qualifying; Recording of previous events; Reporting; Reproductive Health; Research; Research Infrastructure; Research Personnel; Resources; Science; Scientist; Series; Stem cells; Structure; Time; Training; Translating; Translational Research; Translations; Universities; Vision; Washington; Woman; Women' s Health; base; behavioral health; cancer genetics; cancer health disparity; career; career development; design; experience; fetal; health disparity; improved; medical schools; multidisciplinary; news; patient oriented; programs; reproductive; skills

DESCRIPTION (provided by applicant): The goal of the Washington University School of Medicine WRHR program is to promote the performance of research and transfer of findings that will benefit the health of women through the development of well-qualified, new Physician Scientists. The program will achieve this goal by providing each scholar with a core seminar series essential for his/her development as an independent investigator in women's health, a suitable mentor who can provide the guidance and expertise to assure successful academic development and skills as an independent investigator, and the research infrastructure and adequate protected time to create an environment conducive to investigation into women's health. This program is unique in that both basic and clinical science tracks separately are available to scholars; however, they train with mentors who cross disciplines and are exposed to both, in order to be able to interact and translate their own training into cooperative research. The leadership, Dr. George Macones as the PI and Dr. Kelle Moley as the PD, reflects this interactive and cooperative approach to career development in Reproductive Sciences. Their distinct backgrounds and different career pathways, Dr. Macones in the area of clinical research and Dr. Moley in the area of basic translational research, create a unique juxtaposition of leadership styles, which complement each other. Their combined efforts and vision represent the necessary melding of academic backgrounds necessary to perform outstanding investigative science in the area of Reproductive Health Research. In addition, such a multidisciplinary program, emphasizing both clinical and basic research equally, will attract the best and brightest scholars to the WUSM WRHR program. This quality sets this Career Development Program apart from those preceding it at other locations. WUSM is ranked the third best medical school in the USA as reported in US News & World Report and it has a rich scientific history in basic and clinical science research. Given our existing strengths, we believe the theme which unites the mentors involved in the WUSM WRHR Program is the translation of basic research into patient-oriented, clinical research to improve women's health. This uniting concept is shared by our specific focus areas of expertise including: 1) Women's Infectious Diseases (Drs. Hultgen, Gordon and Peipert); 2) Endometrial Cancer: Genetics and Cancer Disparities (Drs. Goodfellow, Milbrandt, Colditz, Rader and Mutch); 3) Developmental Biology: Stem Cells and Origins of Adult Disease (Drs. Moley, Schedl, Gottleib, Schaffer, and Semenkovich); 4) Behavioral Health, Health Disparities and Contraception (Drs. Peipert, Cottler and Gelbart); 5) Developmental Neurology and Maternal Fetal Physiology (Drs. Inder, VanEssen, and Holtzman; 6) Placental Biology and Maternal Fetal Interaction (Drs. Nelson, Atkinson and Yokoyama). PUBLIC RELEVANCE: The long term objective of this application is to take advantage of the significant resources and experience within WUSM and the Department of OB/GYN to train and promote the development of future leaders in biomedical research in the reproductive sciences. This structured and thoughtfully designed program will allow them the opportunity to immerse themselves in the reproductive sciences in a way in which they may not have been able to pursue in a broader, scientific discipline. If successful, we hope to produce well trained physician scientists who will pursue reproductive research questions with a basic science-driven approach or a clinical- based investigative strategy combined with an appreciation and understanding of both.

描述（由申请人提供）：华盛顿大学医学院 WRHR 项目的目标是通过培养高素质的新医师科学家来促进研究成果和成果转化，从而造福于女性的健康。该计划将通过以下方式实现这一目标：为每位学者提供对他/她作为女性健康独立研究者的发展至关重要的核心研讨会系列、能够提供指导和专业知识以确保成功的学术发展和作为独立研究者的技能的合适导师、以及研究基础设施和足够的受保护时间以创造有利于调查女性健康的环境。该项目的独特之处在于，基础科学和临床科学课程分别向学者开放；然而，他们与跨学科且接触这两个学科的导师一起接受培训，以便能够互动并将自己的培训转化为合作研究。 George Macones 博士作为 PI 和 Kelle Moley 博士作为 PD 的领导层反映了生殖科学领域这种互动和合作的职业发展方法。临床研究领域的 Macones 博士和基础转化研究领域的 Moley 博士有着不同的背景和不同的职业道路，创造了独特的领导风格并置，相得益彰。他们的共同努力和愿景代表了在生殖健康研究领域开展杰出科学研究所必需的学术背景的必要融合。此外，这样一个同时强调临床和基础研究的多学科项目将吸引最优秀、最聪明的学者加入 WUSM WRHR 项目。这种品质使该职业发展计划与其他地方的职业发展计划区别开来。据《美国新闻与世界报道》报道，WUSM 被评为美国第三好的医学院，在基础和临床科学研究方面拥有丰富的科学历史。鉴于我们现有的优势，我们相信参与 WUSM WRHR 项目的导师团结起来的主题是将基础研究转化为以患者为导向的临床研究，以改善女性健康。我们的特定重点专业领域共享这一统一概念，包括： 1) 女性传染病（Hultgen、Gordon 和 Peipert 博士）； 2) 子宫内膜癌：遗传学和癌症差异（Goodfellow、Milbrandt、Colditz、Rader 和 Mutch 博士）； 3) 发育生物学：干细胞和成人疾病的起源（Moley、Schedl、Gottleib、Schaffer 和 Semenkovich 博士）； 4) 行为健康、健康差异和避孕（Peipert、Cottler 和 Gelbart 博士）； 5) 发育神经学和母胎生理学（Inder、VanEssen 和 Holtzman 博士）；6) 胎盘生物学和母胎相互作用（Nelson、Atkinson 和 Yokoyama 博士）。 公众相关性：此应用程序的长期目标是利用 WUSM 和妇产科的重要资源和经验来培训和促进生殖科学生物医学研究未来领导者的发展。这个结构化且精心设计的项目将使他们有机会以一种他们可能无法在更广泛的科学学科中追求的方式沉浸在生殖科学中。如果成功，我们希望培养训练有素的医师科学家，他们将采用基础科学驱动的方法或基于临床的研究策略，并结合对两者的欣赏和理解来追求生殖研究问题。