Women's Reproductive Health Research Career Development Program at W.U., St Louis

描述(由申请者提供)：华盛顿大学医学院WRHR计划的目标是通过培养合格的新内科科学家来促进研究的绩效和研究成果的转移，这些成果将有利于妇女的健康。该方案将通过以下方式实现这一目标：为每一位学者提供一系列核心研讨会，这对他/她作为妇女健康独立调查员的发展至关重要；为每位学者提供能够提供指导和专业知识以确保成功的学术发展和作为一名独立调查员的技能的合适导师；为每一位学者提供研究基础设施和充分的保护时间，以创造一个有利于妇女健康调查的环境。该计划的独特之处在于，基础和临床科学课程分别向学者提供；然而，他们与跨学科的导师一起培训，并接触到这两个学科，以便能够互动并将自己的培训转化为合作研究。领导层，乔治·马科内斯博士担任PI，Kelle Moley博士担任PD，反映了生殖科学职业发展的这种互动和合作的方法。他们不同的背景和不同的职业道路，在临床研究领域的Macone博士和在基础翻译研究领域的Moley博士，创造了一种独特的并列领导风格，这种风格相辅相成。他们的共同努力和远见代表了在生殖健康研究领域开展杰出调查科学所必需的学术背景的必要融合。此外，这样一个同时重视临床和基础研究的多学科项目，将吸引最优秀和最聪明的学者加入WUSM WRHR项目。这一特点使这个职业发展计划有别于其他地方之前的那些计划。据《美国新闻与世界报道》报道，密歇根州立大学是美国第三好的医学院，在基础和临床科学研究方面有着丰富的科学历史。鉴于我们现有的优势，我们相信，将参与WUSM WRHR计划的导师团结在一起的主题是将基础研究转化为以患者为导向的临床研究，以改善妇女的健康。这一统一的概念被我们的特定专业领域共享，包括：1)妇女传染病(胡尔特根、戈登和佩佩特博士)；2)子宫内膜癌：遗传学和癌症差异(古德费罗、米尔布兰特、科尔迪茨、雷德和穆奇博士)；3)发育生物学：干细胞和成人疾病的起源(莫利、谢德尔、戈特莱布、谢弗和塞门科维奇博士)；4)行为健康、健康差异和避孕(佩佩特、科特勒和格尔巴特博士)；5)发育神经学和母胎生理学(英德、范埃森和霍尔兹曼博士；6)胎盘生物学和母胎相互作用(纳尔逊、阿特金森和横山博士)。 公共相关性：这项申请的长期目标是利用妇产科和妇产科的大量资源和经验，培训和促进生殖科学领域未来生物医学研究的领导者的发展。这个结构严谨、设计周到的项目将让他们有机会以一种他们可能无法在更广泛的科学学科中追求的方式，沉浸在生殖科学中。如果成功，我们希望培养出训练有素的内科科学家，他们将以基础科学驱动的方法或以临床为基础的调查策略结合对两者的欣赏和理解来研究生殖研究问题。

DESCRIPTION (provided by applicant): The goal of the Washington University School of Medicine WRHR program is to promote the performance of research and transfer of findings that will benefit the health of women through the development of well-qualified, new Physician Scientists. The program will achieve this goal by providing each scholar with a core seminar series essential for his/her development as an independent investigator in women's health, a suitable mentor who can provide the guidance and expertise to assure successful academic development and skills as an independent investigator, and the research infrastructure and adequate protected time to create an environment conducive to investigation into women's health. This program is unique in that both basic and clinical science tracks separately are available to scholars; however, they train with mentors who cross disciplines and are exposed to both, in order to be able to interact and translate their own training into cooperative research. The leadership, Dr. George Macones as the PI and Dr. Kelle Moley as the PD, reflects this interactive and cooperative approach to career development in Reproductive Sciences. Their distinct backgrounds and different career pathways, Dr. Macones in the area of clinical research and Dr. Moley in the area of basic translational research, create a unique juxtaposition of leadership styles, which complement each other. Their combined efforts and vision represent the necessary melding of academic backgrounds necessary to perform outstanding investigative science in the area of Reproductive Health Research. In addition, such a multidisciplinary program, emphasizing both clinical and basic research equally, will attract the best and brightest scholars to the WUSM WRHR program. This quality sets this Career Development Program apart from those preceding it at other locations. WUSM is ranked the third best medical school in the USA as reported in US News & World Report and it has a rich scientific history in basic and clinical science research. Given our existing strengths, we believe the theme which unites the mentors involved in the WUSM WRHR Program is the translation of basic research into patient-oriented, clinical research to improve women's health. This uniting concept is shared by our specific focus areas of expertise including: 1) Women's Infectious Diseases (Drs. Hultgen, Gordon and Peipert); 2) Endometrial Cancer: Genetics and Cancer Disparities (Drs. Goodfellow, Milbrandt, Colditz, Rader and Mutch); 3) Developmental Biology: Stem Cells and Origins of Adult Disease (Drs. Moley, Schedl, Gottleib, Schaffer, and Semenkovich); 4) Behavioral Health, Health Disparities and Contraception (Drs. Peipert, Cottler and Gelbart); 5) Developmental Neurology and Maternal Fetal Physiology (Drs. Inder, VanEssen, and Holtzman; 6) Placental Biology and Maternal Fetal Interaction (Drs. Nelson, Atkinson and Yokoyama). PUBLIC RELEVANCE: The long term objective of this application is to take advantage of the significant resources and experience within WUSM and the Department of OB/GYN to train and promote the development of future leaders in biomedical research in the reproductive sciences. This structured and thoughtfully designed program will allow them the opportunity to immerse themselves in the reproductive sciences in a way in which they may not have been able to pursue in a broader, scientific discipline. If successful, we hope to produce well trained physician scientists who will pursue reproductive research questions with a basic science-driven approach or a clinical- based investigative strategy combined with an appreciation and understanding of both.