Women's Reproductive Health Research Career Development Program at W.U., St Louis

圣路易斯 W.U. 妇女生殖健康研究职业发展计划

• 批准号: 7942036
• 负责人: GEORGE A MACONES
• 金额: $ 47.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942036
• 关键词: Area; Barker Hypothesis; Basic Science; Biology; Biomedical Research; Clinical; Clinical Research; Clinical Sciences; Communicable Diseases; Complement; Contraceptive methods; Development; Developmental Biology; Discipline; Endometrial Carcinoma; Environment; Future; Goals; Health Benefit; Investigation; Leadership; Location; Mentors; Neurology; Pathway interactions; Performance; Physicians; Physiology; Qualifying; Recording of previous events; Reporting; Reproductive Health; Research; Research Infrastructure; Research Personnel; Resources; Science; Scientist; Series; Stem cells; Structure; Time; Training; Translating; Translational Research; Translations; Universities; Vision; Washington; Woman; Women' s Health; base; behavioral health; cancer genetics; cancer health disparity; career; career development; design; experience; fetal; health disparity; improved; medical schools; multidisciplinary; news; patient oriented; programs; reproductive; skills

DESCRIPTION (provided by applicant): The goal of the Washington University School of Medicine WRHR program is to promote the performance of research and transfer of findings that will benefit the health of women through the development of well-qualified, new Physician Scientists. The program will achieve this goal by providing each scholar with a core seminar series essential for his/her development as an independent investigator in women's health, a suitable mentor who can provide the guidance and expertise to assure successful academic development and skills as an independent investigator, and the research infrastructure and adequate protected time to create an environment conducive to investigation into women's health. This program is unique in that both basic and clinical science tracks separately are available to scholars; however, they train with mentors who cross disciplines and are exposed to both, in order to be able to interact and translate their own training into cooperative research. The leadership, Dr. George Macones as the PI and Dr. Kelle Moley as the PD, reflects this interactive and cooperative approach to career development in Reproductive Sciences. Their distinct backgrounds and different career pathways, Dr. Macones in the area of clinical research and Dr. Moley in the area of basic translational research, create a unique juxtaposition of leadership styles, which complement each other. Their combined efforts and vision represent the necessary melding of academic backgrounds necessary to perform outstanding investigative science in the area of Reproductive Health Research. In addition, such a multidisciplinary program, emphasizing both clinical and basic research equally, will attract the best and brightest scholars to the WUSM WRHR program. This quality sets this Career Development Program apart from those preceding it at other locations. WUSM is ranked the third best medical school in the USA as reported in US News & World Report and it has a rich scientific history in basic and clinical science research. Given our existing strengths, we believe the theme which unites the mentors involved in the WUSM WRHR Program is the translation of basic research into patient-oriented, clinical research to improve women's health. This uniting concept is shared by our specific focus areas of expertise including: 1) Women's Infectious Diseases (Drs. Hultgen, Gordon and Peipert); 2) Endometrial Cancer: Genetics and Cancer Disparities (Drs. Goodfellow, Milbrandt, Colditz, Rader and Mutch); 3) Developmental Biology: Stem Cells and Origins of Adult Disease (Drs. Moley, Schedl, Gottleib, Schaffer, and Semenkovich); 4) Behavioral Health, Health Disparities and Contraception (Drs. Peipert, Cottler and Gelbart); 5) Developmental Neurology and Maternal Fetal Physiology (Drs. Inder, VanEssen, and Holtzman; 6) Placental Biology and Maternal Fetal Interaction (Drs. Nelson, Atkinson and Yokoyama). PUBLIC RELEVANCE: The long term objective of this application is to take advantage of the significant resources and experience within WUSM and the Department of OB/GYN to train and promote the development of future leaders in biomedical research in the reproductive sciences. This structured and thoughtfully designed program will allow them the opportunity to immerse themselves in the reproductive sciences in a way in which they may not have been able to pursue in a broader, scientific discipline. If successful, we hope to produce well trained physician scientists who will pursue reproductive research questions with a basic science-driven approach or a clinical- based investigative strategy combined with an appreciation and understanding of both.

描述（由申请人提供）：医学WRHR计划的华盛顿大学学院的目标是促进研究和研究成果的转让，这将有利于妇女的健康，通过发展合格的，新的医生科学家的表现。该方案将通过向每位学者提供一系列核心研讨会来实现这一目标，这些研讨会对他/她作为妇女健康独立调查员的发展至关重要，一位能够提供指导和专业知识的合适导师，以确保成功的学术发展和作为独立调查员的技能，以及研究基础设施和足够的保护时间，以创造有利于调查妇女健康的环境。该计划的独特之处在于，基础和临床科学轨道分别提供给学者;然而，他们与跨学科的导师一起训练，并接触到两者，以便能够互动并将自己的培训转化为合作研究。领导层，乔治Macones博士作为PI和博士Kelle Moley作为PD，反映了这种互动和合作的方法在生殖科学的职业发展。他们不同的背景和不同的职业道路，临床研究领域的Macones博士和基础转化研究领域的Moley博士，创造了一种独特的领导风格并置，相辅相成。他们的共同努力和愿景代表了在生殖健康研究领域进行杰出调查科学所需的学术背景的必要融合。此外，这样一个多学科的计划，强调临床和基础研究平等，将吸引最好的和最聪明的学者WUSM WRHR计划。这一品质使本职业发展计划有别于其他地点之前的职业发展计划。据《美国新闻与世界报道》报道，WUSM被评为美国第三好的医学院，在基础和临床科学研究方面拥有丰富的科学历史。鉴于我们现有的优势，我们认为，团结参与WUSM WRHR计划的导师的主题是将基础研究转化为以患者为导向的临床研究，以改善妇女的健康。这一统一的概念也适用于我们的特定重点专业领域，包括：1）女性传染病（Hultgen，Gordon和Peipert博士）; 2）子宫内膜癌：遗传学和癌症差异（Goodfellow，Milbrandt，科迪茨，Rader和Mutch博士）; 3）发育生物学：干细胞和成人疾病的起源（Moley，Schedl，Gottleib，Schaffer和Semenkovich博士）; 4）行为健康，健康差异和避孕（Peipert、Cottler和Gelbart博士）; 5）发育神经学和母体胎儿生理学（Drs. Inder，VanEssen，and Holtzman; 6）胎盘生物学和母胎相互作用（Drs.纳尔逊，阿特金森和横山）。 公众相关性：该申请的长期目标是利用WUSM和OB/GYN部门的重要资源和经验，培养和促进生殖科学生物医学研究未来领导者的发展。这个结构化和精心设计的计划将使他们有机会沉浸在生殖科学中，他们可能无法在更广泛的科学学科中追求。如果成功的话，我们希望培养出训练有素的医生科学家，他们将以基础科学为导向的方法或以临床为基础的调查策略，并结合对两者的理解和理解来追求生殖研究问题。