Women's Reproductive Health Research Career Development Program at W.U., St Louis

描述（由申请人提供）：华盛顿大学医学院WRHR项目的目标是通过培养合格的新医师科学家来促进研究成果的表现和成果的转移，这些成果将有利于妇女的健康。为了实现这一目标，该计划将为每位学者提供一个核心系列研讨会，这对他/她作为妇女健康独立研究者的发展至关重要，一个合适的导师可以提供指导和专业知识，以确保作为独立研究者的学术发展和技能的成功，以及研究基础设施和足够的保护时间，以创造一个有利于调查妇女健康的环境。这个项目的独特之处在于，基础科学和临床科学分别对学者开放；然而，他们与跨学科的导师一起训练，并接触到这两种学科，以便能够相互作用并将自己的训练转化为合作研究。领导George Macones博士作为PI和Kelle Moley博士作为PD，反映了这种互动和合作的方式在生殖科学的职业发展。Macones博士在临床研究领域，Moley博士在基础转化研究领域，他们不同的背景和不同的职业道路，创造了一种独特的领导风格，相互补充。他们的共同努力和远见代表了在生殖健康研究领域进行杰出调查科学所必需的学术背景的必要融合。此外，这样一个多学科的项目，强调临床和基础研究并重，将吸引最优秀和最聪明的学者到WUSM WRHR项目。这种品质使这个职业发展项目与其他地方的项目不同。被《美国新闻与世界报道》评为美国第三大医学院，在基础和临床科学研究方面有着丰富的科学历史。鉴于我们现有的优势，我们认为，将WUSM妇女健康资源项目的导师团结在一起的主题是将基础研究转化为以患者为导向的临床研究，以改善妇女健康。这一统一的概念是由我们的具体重点专业领域共享的，包括：1)妇女传染病(博士；胡尔特根，戈登和佩珀特)；子宫内膜癌：遗传学和癌症差异（博士论文）；Goodfellow, Milbrandt, Colditz, Rader and Mutch)；发育生物学：干细胞和成人疾病的起源（博士）；Moley, schel, Gottleib， Schaffer和Semenkovich)；4)行为健康、健康差异与避孕（博士论文）；佩珀特，科特勒和盖尔巴特)；5)发育神经学与母胎生理学；因德尔、范埃森和霍尔茨曼；6)胎盘生物学与母胎相互作用（博士论文）；纳尔逊，阿特金森和横山)。

DESCRIPTION (provided by applicant): The goal of the Washington University School of Medicine WRHR program is to promote the performance of research and transfer of findings that will benefit the health of women through the development of well-qualified, new Physician Scientists. The program will achieve this goal by providing each scholar with a core seminar series essential for his/her development as an independent investigator in women's health, a suitable mentor who can provide the guidance and expertise to assure successful academic development and skills as an independent investigator, and the research infrastructure and adequate protected time to create an environment conducive to investigation into women's health. This program is unique in that both basic and clinical science tracks separately are available to scholars; however, they train with mentors who cross disciplines and are exposed to both, in order to be able to interact and translate their own training into cooperative research. The leadership, Dr. George Macones as the PI and Dr. Kelle Moley as the PD, reflects this interactive and cooperative approach to career development in Reproductive Sciences. Their distinct backgrounds and different career pathways, Dr. Macones in the area of clinical research and Dr. Moley in the area of basic translational research, create a unique juxtaposition of leadership styles, which complement each other. Their combined efforts and vision represent the necessary melding of academic backgrounds necessary to perform outstanding investigative science in the area of Reproductive Health Research. In addition, such a multidisciplinary program, emphasizing both clinical and basic research equally, will attract the best and brightest scholars to the WUSM WRHR program. This quality sets this Career Development Program apart from those preceding it at other locations. WUSM is ranked the third best medical school in the USA as reported in US News & World Report and it has a rich scientific history in basic and clinical science research. Given our existing strengths, we believe the theme which unites the mentors involved in the WUSM WRHR Program is the translation of basic research into patient-oriented, clinical research to improve women's health. This uniting concept is shared by our specific focus areas of expertise including: 1) Women's Infectious Diseases (Drs. Hultgen, Gordon and Peipert); 2) Endometrial Cancer: Genetics and Cancer Disparities (Drs. Goodfellow, Milbrandt, Colditz, Rader and Mutch); 3) Developmental Biology: Stem Cells and Origins of Adult Disease (Drs. Moley, Schedl, Gottleib, Schaffer, and Semenkovich); 4) Behavioral Health, Health Disparities and Contraception (Drs. Peipert, Cottler and Gelbart); 5) Developmental Neurology and Maternal Fetal Physiology (Drs. Inder, VanEssen, and Holtzman; 6) Placental Biology and Maternal Fetal Interaction (Drs. Nelson, Atkinson and Yokoyama). PUBLIC RELEVANCE: The long term objective of this application is to take advantage of the significant resources and experience within WUSM and the Department of OB/GYN to train and promote the development of future leaders in biomedical research in the reproductive sciences. This structured and thoughtfully designed program will allow them the opportunity to immerse themselves in the reproductive sciences in a way in which they may not have been able to pursue in a broader, scientific discipline. If successful, we hope to produce well trained physician scientists who will pursue reproductive research questions with a basic science-driven approach or a clinical- based investigative strategy combined with an appreciation and understanding of both.