A Whole Systems Approach to the Study of Ayurveda for Cancer Survivorship

阿育吠陀癌症生存研究的整体系统方法

• 批准号: 8056640
• 负责人: Anand Dhruva
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8056640
• 关键词: Accounting; Acupuncture procedure; Address; Aftercare; Anxiety; Applications Grants; Attention; Behavioral Research; Biological Factors; Botanicals; California; Cancer Patient; Cancer Survivor; Cancer Survivorship; Caring; Chinese Traditional Medicine; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Communities; Complementary and alternative medicine; Complex; Control Groups; Controlled Study; Data; Data Analyses; Data Collection; Diagnosis; Disease remission; Enrollment; Equilibrium; European Organization for Research and Treatment of Cancer; Evaluation; Fatigue; Foundations; Future; Goals; HIV; Healed; Health; Healthcare; Hematologist; Individual; Institute of Medicine (U.S.); Integrative Medicine; Interleukin-6; Intervention; Interview; Investigation; K-Series Research Career Programs; Lead; Learning; Life Style; Malignant Neoplasms; Manuals; Medical Oncologist; Medicine; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modality; Modeling; Oncologist; Outcome; Outcome Measure; Patient Self-Report; Patients; Persons; Pilot Projects; Placebo Effect; Preventive Intervention; Qualitative Methods; Qualitative Research; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Reporting; Reproducibility; Research; Research Methodology; Research Personnel; Residual state; Sample Size; Sampling; San Francisco; Sleeplessness; Surveys; Symptoms; System; Techniques; Testing; Therapeutic Touch; Time; Treatment Efficacy; Universities; Videotape; Yoga; anakinra; arm; ayurveda; base; cancer care; cancer therapy; career; design; experience; healing; improved; malignant breast neoplasm; nutrition; oncology; patient population; programs; prospective; psychosocial; public health relevance; symptom management; treatment planning; virtual

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Anand Dhruva, a medical oncologist/hematologist at the University of California, San Francisco. Dr. Dhruva is establishing himself as a young investigator in complementary and alternative medicine (CAM) and cancer symptom management. This K23 will provide Dr. Dhruva with the support necessary to accomplish the following goals: (1) to develop into an Independent clinical investigator focusing on the rigorous study and successful integration of CAM modalities into conventional oncology care; (2) to learn and apply compatible research methods for the study of whole systems of medicine, with focused expertise in the study of the application of Ayurveda to the oncology setting; and (3) to learn and apply advanced clinical research and qualitative methods in clinical studies. To achieve these goals, Dr. Dhruva has assembled a mentoring team comprised of primary mentor, Dr. Frederick Hecht, Director of Research at the Osher Center for Integrative Medicine, who conducts clinical investigations in CAM and HIV, and three co-mentors: Dr. Christine Miaskowski, an expert in the study of cancer-related symptoms and quality of life; Dr. Donald Abrams, an oncologist who focuses on integrative oncology; and Dr. Shelley Adler, an expert in qualitative research. Despite achieving remission or cure, many cancer survivors discover that the residual symptoms due to the cancer and/or the treatment of the cancer to be difficult, disabling, and impair quality of life. Whole systems approaches to health, such as Ayurveda, have potential benefits for improving quality of life and symptoms in cancer survivors. Complex, individualized interventions, such as those used in Ayurveda, are currently being studied using the technique of "manualization," in which a study manual is utilized to balance the competing concerns of reproducibility and ecological validity. Dr. Dhruva's research will focus on developing a manualized Ayurvedic approach to improve cancer survivor quality of life and symptoms (Aim 1) and then conducting a pilot randomized controlled trial to assess feasibility and obtain preliminary estimates of efficacy of a manualized Ayurvedic approach to improve quality of life and symptoms among breast cancer survivors (Aim 2). This research will form the basis for a larger randomized controlled trial of Ayurveda (using the manualized approach developed in this K award) that will investigate the efficacy of Ayurveda to improve quality of life and symptoms among breast cancer survivors, which will be proposed in a subsequent ROl grant application. PUBLIC HEALTH RELEVANCE: With increasing numbers of cancer survivors, improving understanding of effective and safe ways to improve quality of life and residual symptoms is important. Given the widespread use of CAM, more evidence from rigorously conducted studies is needed to guide its successful integration into modern healthcare.

描述（由申请人提供）：这是一份为弗朗西斯科加州大学医学肿瘤学家/血液学家Anand Dhruva博士申请K23奖的申请。Dhruva博士正在将自己打造成一名补充和替代医学（CAM）和癌症症状管理的年轻研究者。该K23将为Dhruva博士提供必要的支持，以实现以下目标：（1）发展成为一名独立的临床研究者，专注于严格的研究和CAM模式与传统肿瘤治疗的成功整合;（2）学习和应用兼容的研究方法来研究整个医学系统，在阿育吠陀应用于肿瘤学环境的研究中具有专注的专业知识;（3）学习和应用先进的临床研究和临床研究中的定性方法。为了实现这些目标，Dhruva博士组建了一个指导团队，由主要导师Frederick Hecht博士和三位共同导师组成：Frederick Hecht博士，他是Osher综合医学中心的研究主任，负责CAM和HIV的临床研究;克莉丝汀Miaskowski博士，癌症相关症状和生活质量研究专家; Donald Abrams博士，专注于综合肿瘤学的肿瘤学家;以及定性研究专家谢莉·阿德勒博士尽管达到缓解或治愈，许多癌症幸存者发现，由于癌症和/或癌症治疗的残留症状是困难的，致残的，并损害生活质量。全系统的健康方法，如阿育吠陀，对改善癌症幸存者的生活质量和症状有潜在的好处。复杂的，个性化的干预措施，如在阿育吠陀中使用的，目前正在研究使用“手动化”的技术，其中一个研究手册是用来平衡的可重复性和生态有效性的竞争问题。Dhruva博士的研究将集中于开发一种手动阿育吠陀方法，以改善癌症幸存者的生活质量和症状（目标1），然后进行一项试点随机对照试验，以评估可行性，并获得手动阿育吠陀方法改善乳腺癌幸存者生活质量和症状的初步估计（目标2）。这项研究将为一项更大规模的阿育吠陀随机对照试验（使用本K奖中开发的手动方法）奠定基础，该试验将调查阿育吠陀改善乳腺癌幸存者生活质量和症状的疗效，这将在随后的ROI拨款申请中提出。 公共卫生关系：随着越来越多的癌症幸存者，提高对改善生活质量和残留症状的有效和安全方法的理解非常重要。鉴于CAM的广泛使用，需要更多来自严格研究的证据来指导其成功融入现代医疗保健。