A Whole Systems Approach to the Study of Ayurveda for Cancer Survivorship

阿育吠陀癌症生存研究的整体系统方法

• 批准号: 8454220
• 负责人: Anand Dhruva
• 金额: $ 12.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8454220
• 关键词: Accounting; Acupuncture procedure; Address; Aftercare; Anxiety; Applications Grants; Attention; Behavioral Research; Biological Factors; Botanicals; California; Cancer Patient; Cancer Survivor; Cancer Survivorship; Caring; Chinese Traditional Medicine; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Communities; Complementary and alternative medicine; Complex; Control Groups; Controlled Study; Data; Data Analyses; Data Collection; Diagnosis; Disease remission; Enrollment; Equilibrium; European Organization for Research and Treatment of Cancer; Evaluation; Fatigue; Foundations; Future; Goals; HIV; Healed; Health; Healthcare; Hematologist; Individual; Institute of Medicine (U.S.); Instruction; Integrative Medicine; Interleukin-6; Intervention; Interview; Investigation; K-Series Research Career Programs; Lead; Learning; Life Style; Malignant Neoplasms; Manuals; Medical Oncologist; Medicine; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modality; Modeling; Oncologist; Outcome; Outcome Measure; Patient Self-Report; Patients; Persons; Pilot Projects; Placebo Effect; Preventive Intervention; Qualitative Methods; Qualitative Research; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Reporting; Reproducibility; Research; Research Methodology; Research Personnel; Residual state; Sample Size; Sampling; San Francisco; Sleeplessness; Surveys; Symptoms; System; Techniques; Testing; Therapeutic Touch; Time; Treatment Efficacy; Universities; Videotape; Yoga; anakinra; arm; ayurveda; base; cancer care; cancer therapy; career; design; experience; healing; improved; malignant breast neoplasm; nutrition; oncology; patient population; programs; prospective; psychosocial; symptom management; treatment planning; virtual

This is an application for a K23 award for Dr. Anand Dhruva, a medical oncologist/hematologist at the University of California, San Francisco. Dr. Dhruva is establishing himself as a young investigator in complementary and alternative medicine (CAM) and cancer symptom management. This K23 will provide Dr. Dhruva with the support necessary to accomplish the following goals: (1) to develop into an Independent clinical investigator focusing on the rigorous study and successful integration of CAM modalities into conventional oncology care; (2) to learn and apply compatible research methods for the study of whole systems of medicine, with focused expertise in the study of the application of Ayurveda to the oncology setting; and (3) to learn and apply advanced clinical research and qualitative methods in clinical studies. To achieve these goals, Dr. Dhruva has assembled a mentoring team comprised of primary mentor, Dr. Frederick Hecht, Director of Research at the Osher Center for Integrative Medicine, who conducts clinical investigations in CAM and HIV, and three co-mentors: Dr. Christine Miaskowski, an expert in the study of cancer-related symptoms and quality of life; Dr. Donald Abrams, an oncologist who focuses on integrative oncology; and Dr. Shelley Adler, an expert in qualitative research. Despite achieving remission or cure, many cancer survivors discover that the residual symptoms due to the cancer and/or the treatment of the cancer to be difficult, disabling, and impair quality of life. Whole systems approaches to health, such as Ayurveda, have potential benefits for improving quality of life and symptoms in cancer survivors. Complex, individualized interventions, such as those used in Ayurveda, are currently being studied using the technique of "manualization," in which a study manual is utilized to balance the competing concerns of reproducibility and ecological validity. Dr. Dhruva's research will focus on developing a manualized Ayurvedic approach to improve cancer survivor quality of life and symptoms (Aim 1) and then conducting a pilot randomized controlled trial to assess feasibility and obtain preliminary estimates of efficacy of a manualized Ayurvedic approach to improve quality of life and symptoms among breast cancer survivors (Aim 2). This research will form the basis for a larger randomized controlled trial of Ayurveda (using the manualized approach developed in this K award) that will investigate the efficacy of Ayurveda to improve quality of life and symptoms among breast cancer survivors, which will be proposed in a subsequent ROl grant application. RELEVANCE (See instructions): With increasing numbers of cancer survivors, improving understanding of effective and safe ways to improve quality of life and residual symptoms is important. Given the widespread use of CAM, more evidence from rigorously conducted studies is needed to guide its successful integration into modern healthcare.

这是为阿南德·德鲁瓦博士申请K23奖项，他是华盛顿大学的内科肿瘤学家/血液学家 加州大学旧金山分校。Dhruva博士正在确立自己作为一名年轻研究员的地位 补充和替代医学(CAM)和癌症症状管理。这款K23将提供 Dhruva博士获得了实现以下目标所需的支持：(1)发展成为一名独立的 临床调查员专注于对CAM模式的严格研究和成功整合 传统的肿瘤学护理；(2)学习和应用兼容的研究方法进行整体研究 医学体系，专注于阿育吠陀在肿瘤学中的应用研究 (3)在临床研究中学习和应用先进的临床研究和定性方法。至 为了实现这些目标，Dhruva博士组建了一个由主要导师Dr。 弗雷德里克·赫克特，奥舍综合医学中心研究主任，负责临床 对CAM和艾滋病毒的调查，以及三位共同导师：克里斯汀·米亚科夫斯基博士，研究 癌症相关症状和生活质量；唐纳德·艾布拉姆斯博士，肿瘤学家，专注于 肿瘤学；以及定性研究专家雪莱·阿德勒博士。 尽管取得了缓解或治愈，许多癌症幸存者发现，由于 癌症和/或癌症的治疗是困难的，使人残疾，并损害生活质量。整体 系统的健康方法，如阿育吠陀，对提高生活质量和 癌症幸存者的症状。复杂的、个性化的干预措施，如阿育吠陀使用的干预措施，是 目前正在使用“手册”技术进行研究，在这种技术中，利用研究手册来平衡 可再生性和生态有效性这两个相互矛盾的问题。德鲁瓦博士的研究将集中在 开发手册阿育吠陀方法以改善癌症幸存者的生活质量和症状(目的 1)然后进行试点随机对照试验，评估可行性，获得初步的 阿育吠陀方法在以下方面改善生活质量和症状的有效性评估 乳腺癌幸存者(目标2)。这项研究将为更大规模的随机对照试验奠定基础。 阿育吠陀(使用在本K奖中开发的手动方法)，将调查 阿育吠陀以改善乳腺癌幸存者的生活质量和症状，这将在#年提出 随后的ROL授权申请。 相关性(请参阅说明)： 随着癌症幸存者人数的增加，提高对有效和安全方法的了解 生活质量和残留症状很重要。鉴于CAM的广泛使用，来自 需要进行严格的研究，以指导其成功融入现代医疗保健。

项目成果

Trajectories and predictors of symptom occurrence, severity, and distress in prostate cancer patients undergoing radiation therapy.

接受放射治疗的前列腺癌患者症状发生、严重程度和痛苦的轨迹和预测因素。

• DOI: 10.1016/j.jpainsymman.2011.10.020
• 发表时间: 2012
• 期刊: Journal of pain and symptom management
• 影响因子: 4.7
• 作者: Knapp,Katie;Cooper,Bruce;Koetters,Theresa;Cataldo,Janine;Dhruva,Anand;Paul,StevenM;West,Claudia;Aouizerat,BradleyE;Miaskowski,Christine
• 通讯作者: Miaskowski,Christine

Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms.

• DOI: 10.1016/j.jpainsymman.2015.05.008
• 发表时间: 2015-11
• 期刊: Journal of pain and symptom management
• 影响因子: 4.7
• 作者: Aouizerat BE;Dhruva A;Paul SM;Cooper BA;Kober KM;Miaskowski C
• 通讯作者: Miaskowski C

Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.

• DOI: 10.1177/1099800414534313
• 发表时间: 2015-03
• 期刊: Biological research for nursing
• 影响因子: 2.5
• 作者: Dhruva A;Aouizerat BE;Cooper B;Paul SM;Dodd M;West C;Wara W;Lee K;Dunn LB;Langford DJ;Merriman JD;Baggott C;Cataldo J;Ritchie C;Kober KM;Leutwyler H;Miaskowski C
• 通讯作者: Miaskowski C