New Faculty for Craniofacial Tissue Engineering and Biology

颅面组织工程和生物学新教师

• 批准号: 7934057
• 负责人: CHARLES SFEIR
• 金额: $ 73.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934057
• 关键词: Address; Admission activity; Applications Grants; Appointment; Architecture; Area; Arts; Award; Basic Science; Biocompatible Materials; Biology; Biomedical Engineering; Biomedical Research; Budgets; Categories; Cell Nucleus; Cells; Clinical; Clinical Research; Collaborations; Complement; Country; Data; Dental; Dental Schools; Department of Defense; Development; Developmental Biology; Discipline of Nursing; Disease; Educational process of instructing; Engineering; Enrollment; Environment; Equipment; Faculty; Floor; Fostering; Foundations; Funding; Funding Opportunities; Genetic; Genetic Research; Goals; Grant; Health; Health Sciences; Health system; Height; Histology; Human; Human Genetics; Incubators; Individual; Industry; Inpatients; Institutes; Institution; Interdisciplinary Study; K-Series Research Career Programs; Laboratories; Laboratory Research; Lead; Leadership; Learning; Life; Light Microscope; Mechanics; Medical Genetics; Medical Research; Medical center; Medicine; Mentors; Microscopy; Mission; Molecular Genetics; Names; Natural regeneration; Oral health; Outpatients; Patient Care; Pennsylvania; Pharmacy Schools; Pharmacy facility; Phenotype; Pilot Projects; Play; Postdoctoral Fellow; Principal Investigator; Process; Productivity; Program Research Project Grants; Public Health; Public Health Schools; Recommendation; Recording of previous events; Recruitment Activity; Regenerative Medicine; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resource Sharing; Resources; Role; School Nursing; Schools; Science; Scientist; Speed; Structure; Students; Temporomandibular Joint; Time; Tissue Engineering; Tissues; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; Visit; Work; arm; base; career; clinical application; clinical infrastructure; clinical practice; craniofacial; dental genetics; design; fluorescence microscope; improved; interdisciplinary approach; interdisciplinary collaboration; interest; medical schools; member; multidisciplinary; operation; oral biology; polarized light; pre-clinical; programs; public health relevance; ranpirnase; regenerative; regenerative therapy; rehabilitation science; research and development; response; square foot; stem cell biology; success; tissue culture; tissue regeneration

DESCRIPTION (provided by applicant): This grant application in response to the RFA-OD-09-005 entitled: "Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers" is aimed to request support for the recruitment of two additional faculty members in the area of craniofacial regeneration in the newly created Center for Craniofacial Regeneration (CCR) at the University of Pittsburgh School of Dental Medicine (SDM).SDM leadership and center directors have set a vision and outlined a clear path to build our research capabilities with the aim to create a Center of Excellence in craniofacial regeneration. The strategy was developed to build on the existing tissue engineering strengths at the University of Pittsburgh which was lacking a concerted effort in the field of craniofacial regeneration. During its short history, CCR has been growing at a steady pace by attracting faculty from the Schools of Engineering and Medicine to join in the efforts, and by recruiting new faculty. This nucleus developed the current strength in CCR in mineralized tissue and TMJ regeneration. Our original plan was to recruit two more faculty at the SDM with the expertise that compliment the CCR activities and support its overall mission. However, due to the current financial crisis, this effort was placed on hold due to budgetary constraints. In order to continue to build on our initial strength in the mineralized tissue and TM] regeneration, and achieve our goal to become a Center of Excellence for Regenerative Medicine, we must continue the recruitment effort to build a critical mass of faculty interested in craniofacial regeneration and achieve a long term sustainability of this research effort. The funding from this grant will provide such an opportunity to reengage in recruitment activities of two faculty members that we initially planned to recruit prior to the financial crisis. These faculty are instrumental in creating a critical mass of researchers working together on developing craniofacial regenerative therapies and more specifically mineralized tissue and TMJ regeneration. This integrated effort with the Engineering and Medical Schools will culminate in improved ranking and stature of CCR and SDM. This award will allow us to progress toward our goal to establish high quality research programs which will lead to revolutionary approaches to craniofacial regeneration and improved patient care. PUBLIC HEALTH RELEVANCE: We propose to recruit two faculty in the areas of craniofacial developmental biology and smart biomaterials that complement the existing multidisciplinary efforts at the Center for Craniofacial Regeneration (CCR) at the University of Pittsburgh. This will allow us to achieve our goal of becoming a center of excellence that will provide revolutionary approaches to craniofacial regeneration which will lead to Improving human health.

描述（由申请人提供）：本资助申请响应RFA-OD-09-005，标题为：“支持新的教师招聘，以加强通过生物医学研究核心中心的研究资源”，旨在请求支持招聘两名额外的教师在颅面再生领域的新成立的颅面再生中心（CCR）在匹兹堡大学牙科医学院（SDM）。SDM的领导和中心主任已经设定了一个愿景，并概述了一个明确的路径，以建立我们的研究能力，旨在创建一个卓越的颅面再生中心。该策略是建立在匹兹堡大学现有的组织工程优势的基础上的，匹兹堡大学在颅面再生领域缺乏协同努力。在其短暂的历史中，CCR一直在稳步增长，吸引了来自工程和医学学院的教师加入，并招募新的教师。该核团在矿化组织和TMJ再生中的CCR中产生电流强度。我们最初的计划是在SDM再招聘两名教师，他们具有补充CCR活动并支持其整体使命的专业知识。然而，由于当前的金融危机，这一努力因预算限制而被搁置。为了继续建立我们在矿化组织和TM]再生的初始实力，并实现我们成为再生医学卓越中心的目标，我们必须继续招聘工作，以建立对颅面再生感兴趣的教师的临界质量，并实现这项研究工作的长期可持续性。这笔赠款的资金将提供这样一个机会，重新参与我们最初计划在金融危机前招聘的两名教师的招聘活动。这些教师有助于创造一个临界质量的研究人员共同开发颅面再生疗法，更具体地说，矿化组织和颞下颌关节再生。这种与工程和医学院的综合努力将最终提高CCR和SDM的排名和地位。该奖项将使我们朝着我们的目标前进，建立高质量的研究项目，这将导致革命性的方法，颅面再生和改善病人护理。 公共卫生关系：我们建议在颅面发育生物学和智能生物材料领域招募两名教师，以补充匹兹堡大学颅面再生中心（CCR）现有的多学科工作。这将使我们能够实现成为卓越中心的目标，为颅面再生提供革命性的方法，从而改善人类健康。

项目成果

Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.

Tfap2β、Casq2、Penk、Zic1 和 Zic3 表达在胚胎小鼠眼睛发育中的视网膜、肌肉和巩膜中的定位。

• DOI: 10.1369/0022155419885112
• 发表时间: 2019
• 期刊: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
• 作者: Wan,Yong;White,Casey;Robert,Nadine;Rogers,MatthewB;Szabo-Rogers,HeatherL
• 通讯作者: Szabo-Rogers,HeatherL

Chondrocyte Polarity During Endochondral Ossification Requires Protein-Protein Interactions Between Prickle1 and Dishevelled2/3.

软骨内骨化过程中软骨细胞的极性需要 Prickle1 和 Dishevelled2/3 之间的蛋白质-蛋白质相互作用。

• DOI: 10.1002/jbmr.4428
• 发表时间: 2021
• 期刊: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
• 作者: Wan,Yong;Szabo-Rogers,HeatherL
• 通讯作者: Szabo-Rogers,HeatherL

Prickle1 regulates differentiation of frontal bone osteoblasts.

Prickle1 调节额骨成骨细胞的分化。

• DOI: 10.1038/s41598-018-36742-0
• 发表时间: 2018
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Wan,Yong;Lantz,Brandi;Cusack,BrianJ;Szabo-Rogers,HeatherL
• 通讯作者: Szabo-Rogers,HeatherL

Finding the Unicorn, a New Mouse Model of Midfacial Clefting.

寻找独角兽，一种新的面中裂小鼠模型。

• DOI: 10.3390/genes11010083
• 发表时间: 2020
• 期刊: Genes
• 影响因子: 3.5
• 作者: Lantz,Brandi;White,Casey;Liu,Xinyun;Wan,Yong;Gabriel,George;Lo,CeciliaWY;Szabo-Rogers,HeatherL
• 通讯作者: Szabo-Rogers,HeatherL