Training in isotopic techniques for metabolic research

描述(由申请人提供)： 本申请代表小鼠代谢和表型鉴定中心(MMPC)网络()及其咨询委员会提交。MMPC网络由五个中心(位于凯斯西部储备大学、辛辛那提大学、德克萨斯西南大学、华盛顿大学、范德比尔特大学、耶鲁大学)和一个协调和生物信息学单位(位于佐治亚医学院)组成。 这一五年期项目的目标是通过组织一系列关于使用同位素技术进行新陈代谢研究的课程和实践讲习班，扩大MMPC网络的教育和培训活动。虽然MMPC网络是为了在小鼠身上提供表型测试而创建的，但它被整合到NIDDK、NHLBI和NIH更广泛的研究和培训活动中。因此，计划中的同位素技术课程和讲习班的范围将不限于对老鼠新陈代谢的调查。负责课程和研讨会的教员在使用同位素进行动物和人类新陈代谢研究方面拥有广泛的专业知识。他们还参与了新的同位素、代谢组和蛋白质组学技术的开发，这将使代谢研究从小鼠扩展到床边。 该项目以MMPC外部咨询委员会成员罗伯特·R·沃尔夫博士的教学和培训专长为基础。沃尔夫博士于1992年创建了一门关于使用同位素进行新陈代谢研究的课程，并与同事们一起讲授了8次。这门课程吸引了来自美国各地的学员。2007年10月，沃尔夫博士和MMPC教员联手教授了一门新版本的同位素课程。这一新课程受到约80名学员的热烈欢迎，是根据本申请将教授的课程的模板。此外，我们计划每年在一名课程教员的实验室里举办一次专门的动手研讨会。

DESCRIPTION (provided by applicant): This application is presented on behalf of the Mouse Metabolic and Phenotyping Center (MMPC) network () and its Advisory Committee. The MMPC network groups five Centers (located at Case Western Reserve University, University of Cincinnati, University of Texas SouthWestern, University of Washington, Vanderbilt University, Yale University) and a Coordinating and Bioinformatics Unit (located at the Medical College of Georgia). The goal of this five-year project is to expand the educational and training activities of the MMPC network by organizing a series of courses and hand-on workshops on the use of isotopic techniques for metabolic investigations. Although the MMPC network was created to provide phenotyping testing in mice, it is integrated in the wider research and training activities of NIDDK, NHLBI and the NIH. Therefore, the scope of the planned courses and workshops on isotope technology will not be limited to investigations of mouse metabolism. The faculty who will run the courses and workshops have wide expertise in the use of isotopes for metabolic studies in animals and humans. They are also involved in the development of new isotopic, metabolomic and proteomic techniques which will allow major expansion of metabolic investigations conducted from the mouse to the bedside. This project builds on the teaching and training expertise of Dr Robert R. Wolfe, a member of the MMPC External Advisory Committee. Dr Wolfe has created in 1992, and taught eight times with colleagues, a course on the use of isotopes for metabolic studies. This course drew trainees from all over the United States. In October 2007, Dr Wolfe and MMPC faculty joined forces to teach a new version of the isotope course. This new course, which was very well received by about 80 trainees, is the template for the courses to be taught under the present application. In addition, we plan to conduct each year one specialized hand-on workshop in the laboratory of a member of the course faculty.