The Development of Sustained Attention in Infants

描述（由申请人提供）：目的是研究幼儿持续注意力的发展，并将持续注意力的发展与并发心率（HR）变化和脑活动（EEG， ERP）联系起来。具体目的是：1)研究14 ~ 26周龄婴儿持续的、被试控制的注意力，并研究注意力对眼球运动对复杂/动态周围刺激的影响；2)利用高密度脑电图和ERP研究婴幼儿计划眼动和识别记忆的皮层基础，研究注意对婴幼儿扫视计划和识别记忆的影响；3)利用婴儿解剖MRI建立真实的皮质源分析模型，以准确识别控制持续注意力对眼球运动、注意力和识别记忆影响的大脑区域。本研究考察了正常儿童的注意力模式，将这些注意力与这个年龄段早期（14至26周）眼球运动的时间和特征联系起来。实验2使用空间线索程序考察婴儿的眼球运动计划，实验3考察注意与识别记忆之间的关系。这两项研究将使用“高密度”脑电图记录来推断注意力导向眼动控制的皮层来源。在这两个实验中，我们将使用婴儿大脑和头部的真实模型来开发皮层源分析模型，以检查ERP的皮层源。结果表明：1)持续注意的年龄变化与眼球运动的发育变化相互作用，影响眼球运动；2)计划眼动和识别记忆将显示与大脑活动变化相关的发育变化；3)利用高密度脑电图记录推断皮层活动的新兴技术将揭示控制婴儿计划性扫视和识别记忆的皮层来源。

DESCRIPTION (provided by applicant): The objectives are to study the development of sustained attention in young infants and to relate development in sustained attention to concurrent heart rate (HR) changes and brain activity (EEG, ERP). The specific aims are: 1) To study sustained, subject-controlled attention in infants from 14 to 26 weeks of age, and to study the effect of attention on eye movements to complex / dynamic peripheral stimuli; 2) To study the cortical basis of planned eye movements and recognition memory in young infants with high- density EEG and ERP, and to study the effect of attention on infant saccade planning and infant, recognition memory; 3) To develop realistic models of cortical source analysis using infant anatomical MRI, to accurately identify brain areas that control the effect of sustained attention on eye movements, attention, and recognition memory. This research examines the patterns of attention found in normal children, relates those attentiontics on the timing and characteristics of eye movements in the early part of this age range (14 to 26 weeks). Experiment 2 examines infant planned eye movements using a spatial cueing procedure and Experiment 3 examines the relation between attention and recognition memory. These two studies will use "high-density" EEG recording to infer cortical sources of attention-directed eye movement control. Models of cortical source analysis using realistic models of infants' brain and head will be developed to examine the cortical sources of ERP in these two experiments. It is predicted that 1) age changes in sustained attention will interact with development changes in eye movements to affect attention-directed eye movements; 2) planned eye movements and recognition memory will show developmental changes that are related to changes in brain activity; 3) emerging technologies for inferring cortical activity using high-density EEG recording should reveal the cortical sources involved in the control of infant planned saccades and recognition memory.