The Development of Sustained Attention in Infants

描述(由申请人提供)：目的是研究婴幼儿持续注意力的发展，并将持续注意力与心率(HR)同步变化和脑活动(EEG，ERP)的发展联系起来。其具体目标是：1)研究14-26周龄婴儿持续的、受试者控制的注意，并研究注意对复杂/动态周围刺激的眼动的影响；2)研究高密度脑电和事件相关电位下婴儿计划眼动和再认记忆的大脑皮层基础，并研究注意对婴儿扫视计划和婴儿再认记忆的影响；3)利用婴儿解剖磁共振发展现实的皮质来源分析模型，以准确地确定控制持续注意对眼动、注意力和再认记忆影响的大脑区域。这项研究考察了在正常儿童中发现的注意力模式，将这些注意力与这个年龄段早期(14至26周)眼球运动的时间和特征联系起来。实验2使用空间线索程序检查婴儿的计划眼球运动，实验3检查注意力和再认记忆之间的关系。这两项研究将使用“高密度”脑电记录来推断注意力定向眼动控制的皮质来源。在这两个实验中，将开发使用婴儿大脑和头部的真实模型的皮质来源分析模型，以检查ERP的皮质来源。据预测，1)持续注意力的年龄变化将与眼球运动的发展变化相互作用，从而影响注意力定向的眼球运动；2)计划的眼球运动和再认记忆将显示与大脑活动变化有关的发育变化；3)使用高密度脑电记录推断皮质活动的新兴技术应该揭示参与控制婴儿计划眼跳和再认记忆的皮质来源。

DESCRIPTION (provided by applicant): The objectives are to study the development of sustained attention in young infants and to relate development in sustained attention to concurrent heart rate (HR) changes and brain activity (EEG, ERP). The specific aims are: 1) To study sustained, subject-controlled attention in infants from 14 to 26 weeks of age, and to study the effect of attention on eye movements to complex / dynamic peripheral stimuli; 2) To study the cortical basis of planned eye movements and recognition memory in young infants with high- density EEG and ERP, and to study the effect of attention on infant saccade planning and infant, recognition memory; 3) To develop realistic models of cortical source analysis using infant anatomical MRI, to accurately identify brain areas that control the effect of sustained attention on eye movements, attention, and recognition memory. This research examines the patterns of attention found in normal children, relates those attentiontics on the timing and characteristics of eye movements in the early part of this age range (14 to 26 weeks). Experiment 2 examines infant planned eye movements using a spatial cueing procedure and Experiment 3 examines the relation between attention and recognition memory. These two studies will use "high-density" EEG recording to infer cortical sources of attention-directed eye movement control. Models of cortical source analysis using realistic models of infants' brain and head will be developed to examine the cortical sources of ERP in these two experiments. It is predicted that 1) age changes in sustained attention will interact with development changes in eye movements to affect attention-directed eye movements; 2) planned eye movements and recognition memory will show developmental changes that are related to changes in brain activity; 3) emerging technologies for inferring cortical activity using high-density EEG recording should reveal the cortical sources involved in the control of infant planned saccades and recognition memory.