ANIMAL BARRIER SHARED RESOURCE

动物屏障共享资源（ABSR）使命提供 环境中，最高质量的动物研究可以进行，同时保持 最高标准的动物护理和动物福利。ABSR的一个主要目标是保持 屏障饲养无特定病原体（SPF）小鼠的健康质量，使其不受外来鼠感染 可能破坏繁殖或混淆研究结果的传染因子。提供屏障壳体， SPF小鼠，同时允许研究人员在监督下进入。AECC调查人员维持育种 克隆，以扩增携带转基因或靶向突变的新菌株， 建立者动物，或重组几个特定的等位基因从不同的遗传基因座成一个有限的一套， 在单一菌株背景下的基因型。频繁方便的访问对调查人员至关重要， 他们可以建立交配，从连续的窝中收集组织活检用于基因型测定， 观察动物的身体和行为特征（表型），特别是，他们的倾向， 发展成肿瘤。此外，许多AECC研究人员使用特定的无病原体啮齿动物， 具有发生自发性肿瘤的遗传倾向或免疫缺陷并耐受肿瘤 异种移植物作为研究特定过程如血管生成和转移的模型， 治疗这些研究者必须经常接触他们的动物以植入肿瘤 组织，监测肿瘤生长，给予各种治疗，并收集组织活检。畜牧 服务，兽医护理和全面的啮齿动物质量保证和检疫计划， 由动物研究所（IAS）提供给AECC。IAS由三个学院组成实验室 动物兽医（包括主任），3名兽医技术员，约40名工作人员 动物管理员、一名设施经理、两名畜牧主管以及办公室行政人员。 除了提供兽医护理外，IAS兽医还负责监督动物护理， 使用程序，监控法规遵从性，并进行小组和个人培训课程， investigators.病理诊断服务由兽医病理学家提供，他还指导 组织学共享资源。

The Animal Barrier Shared Resource (ABSR) supports the mission of the AECC by providing an environment in which the highest quality of animal research studies can be conducted while maintaining the highest standards of animal care and animal welfare. A major objective of the ABSR is to maintain the health quality of barrier housed specific pathogen-free (SPF) mice, keeping them free of adventitious murine infectious agents that could disrupt breeding or confound research results. Barrier housing is provided for SPF mice while permitting supervised access for investigators. AECC investigators maintain breeding colonies either to expand novel strains bearing transgene or targeted mutations from genetically-manipulated founder animals, or to recombine several specific alleles from different genetic loci into a limited set of genotypes on a single strain background. Frequent convenient access is crucial for investigators so that they may set up matings, collect tissue biopsies from successive litters for genotype determination, and observe animals for physical and behavioral characteristics (phenotype), specifically, their propensity to develop neoplasia. In addition, many AECC investigators use specific pathogen-free rodents that either have a genetic predisposition to develop spontaneous neoplasia or are immunodeficient and tolerate tumor xenografts as models to study specific processes such as angiogenesis and metastasis and for testing antineoplastic therapies. These investigators must have frequent access to their animals to implant tumor tissues, monitor tumor growth, administer various treatments, and collect tissue biopsies. Animal husbandry services, veterinary care, and comprehensive rodent quality assurance and quarantine programs are provided to the AECC by the Institute of Animal Studies (IAS). The IAS consists of three faculty Laboratory Animal Veterinarians (including the Director), three Veterinary Technicians, a staff of approximately 40 Animal Caretakers, a Facilities Manager, two Husbandry Supervisors, as well as office administrative staff. In addition to providing veterinary care, the IAS veterinarians also provide oversight of the animal care and use program, monitor regulatory compliance, and conduct small-group and individual training sessions for investigators. Pathology diagnostic services are provided by a Veterinary Pathologist who also directs the Histopathology Shared Resource.