Animal Barrier

项目摘要-动物屏障共享资源 动物屏障共享资源(ABSR)提供无特定病原体(SPF)的啮齿动物住所和 对阿尔伯特·爱因斯坦癌症中心(AECC)成员和中心的研究至关重要的服务 程序性活动。ABSR是爱因斯坦的AAALAC动物研究所的一个组成部分 经认可的动物护理和使用计划。ABSR提供广泛的畜牧业服务 包括：兽医护理、全面的啮齿动物质量保证和检疫计划。有一个 在允许使用设施之前，为AECC成员及其受训人员提供强化培训计划 为了实现配对，基因分型后代，鉴定小鼠的表型，移植肿瘤和测量他们的 生长，给药，并获得组织活检。AECC调查人员保持新的繁殖群体 携带与癌症生物学相关的转基因或靶向突变的小鼠品系。他们的研究还包括 涉及复杂的育种方案，将来自不同遗传基因座的特定等位基因重新组合成一组有限的 单一菌株背景下的基因分型。许多AECC研究人员使用免疫缺陷小鼠来耐受 以人肿瘤移植瘤为模型研究肿瘤发生、血管生成、侵袭和转移以及 在人类癌症中测试抗肿瘤疗法。AECC成员占ABSR总使用量的大部分 (笼养--天数)。ABSR包括三个SPF啮齿类动物住房设施，整个SPF老鼠住房 可容纳25,000个笼子。人员包括三名教员实验动物兽医(包括 主任)、一名业务经理、三名设施主管、四名兽医技术员、办公室工作人员和 大约42名动物饲养员。

PROJECT SUMMARY – ANIMAL BARRIER SHARED RESOURCE The Animal Barrier Shared Resource (ABSR) provides specific pathogen-free (SPF) rodent housing and services that are critical to the research of Albert Einstein Cancer Center (AECC) members and the Center's programmatic activities. The ABSR is a component of the Institute of Animal Studies (IAS), Einstein's AAALAC accredited animal care & use program. The ABSR provides a broad spectrum of animal husbandry services including: veterinary care, comprehensive rodent quality assurance and quarantine programs. There is an intensive program of instruction for AECC members and their trainees prior to allowing access to the facilities to implement matings, genotype progeny, characterize mouse phenotypes, implant tumors and measure their growth, administer drugs, and obtain tissue biopsies. AECC investigators maintain breeding colonies of novel mouse strains bearing transgenes or targeted mutations relevant to cancer biology. Their research also involves complex breeding schemes to recombine specific alleles from different genetic loci into a limited set of genotypes on a single strain background. Many AECC investigators use immune deficient mice that tolerate human tumor xenografts as models to study tumorigenesis, angiogenesis, invasion, and metastasis, as well as to test anti-neoplastic therapies in human cancers. AECC members account for most of the total ABSR usage (cage care-days). The ABSR includes three SPF rodent housing facilities with an overall SPF mouse housing capacity of 25,000 cages. Personnel include three faculty Laboratory Animal Veterinarians (including the Director), an Operations Manager, three Facility Supervisors, four Veterinary Technicians, office staff, and approximately 42 Animal Caretakers.