Glycosaminoglycan reactivity in lupus as a predictor of disease

狼疮中的糖胺聚糖反应性作为疾病的预测因子

• 批准号: 8130961
• 负责人: FEI F SHIH
• 金额: $ 8.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8130961
• 关键词: Antibodies; Autoantibodies; Autoimmune Process; Biological Markers; Childhood; DNA Structure; Disease; Doctor of Medicine; Doctor of Philosophy; Feasibility Studies; Funding; Glycosaminoglycans; Lupus; Modeling; Mus; Organ; Patients; Pattern; Pilot Projects; Production; Structure; Systemic Lupus Erythematosus; base; cross reactivity; novel

Funded Pilot and Feasibility Study #2: Title: Glycosaminoglycan reactivity in lupus as a predictor of disease PI: Fei Shih, M.D., Ph.D. A. Specific Aims Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies and autoimmune attack of multiple organs. We hypothesized that there are novel targets yet to be discovered for SLE and these may serve as predictors of disease. Based on the highly patterned structure of DNA, we hypothesized that cross reactivity to glycosaminoglycans (GAGs), also a highly patterned structure, may serve as a biomarker for various disease manifestations. This pilot study examines aGAG reactivity in a murine model of SLE and extends aGAG analysis to pediatric patients with SLE with the following specific aims: 1) An unbiased examination of aGAG antibodies in KRN/G7m mice, a murine model of SLE; and 2) Characterize aGAG antibodies in SLE patients and correlation with disease.

资助的试点和可行性研究#2： 标题：狼疮患者的糖胺多糖反应可作为疾病的预测指标 派：施飞，医学博士，博士。 A.具体目标 系统性红斑狼疮(SLE)的特征是产生自身抗体和 多器官的自身免疫性攻击。我们假设还会有新的目标出现 被发现为系统性红斑狼疮，这些可以作为疾病的预测指标。基于高度图案化的 结构，我们假设与糖胺多聚糖(GAG)有交叉反应，也是一种高度 图案化结构，可作为各种疾病表现的生物标志物。这项初步研究 检测SLE小鼠模型中AGAG的反应性，并将AGAG分析扩展到儿科 系统性红斑狼疮患者有以下特殊目的：1)对抗原抗体进行无偏见的检查 在KRN/G7M小鼠中，建立了系统性红斑狼疮的小鼠模型；以及2)表征了系统性红斑狼疮患者的抗原抗体 与疾病的相关性。